Antinutritional factors in pearl millet grains: Phytate and goitrogens content variability and molecular characterization of genes involved in their pathways

Boncompagni, Eleonora; Orozco-Arroyo, Gregorio; Cominelli, Eleonora; Gangashetty, Prakash; Grando, Stefania; Zu, Theophilus Tenutse Kwaku; Daminati, Maria Gloria; Nielsen, Erik; Sparvoli, Francesca

doi:10.1371/journal.pone.0198394

Cited by 54 publications

(26 citation statements)

References 59 publications

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“…Furthermore, a recent study on breeding of pearl millet analysed the content of phytic acid and goitrogenic C-glycosylflavones (C-GFs) in pearl millet grains, providing information on genes involved in their biosynthesis. It was shown that large variability existed in both phytic acid and C-GFs contents, implying immense potential for selecting germplasms that are low in these contents, which would help maximize the benefits out of nutrients present in millet-based food [37]. In the current study, pearl millet was included in MDM twice a week and there was no record of developing mineral deficiency or thyroid related problems with the study sample.…”

Section: Discussionmentioning

confidence: 92%

Acceptance and Impact of Millet-Based Mid-Day Meal on the Nutritional Status of Adolescent School Going Children in a Peri Urban Region of Karnataka State in India

et al. 2019

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The study assessed the potential for use of millets in mid-day school meal programs for better nutritional outcomes of children in a peri-urban region of Karnataka, India, where children conventionally consumed a fortified rice-based mid-day meal. For a three-month period, millet-based mid-day meals were fed to 1500 adolescent children at two schools, of which 136 were studied as the intervention group and were compared with 107 other children in two other schools that did not receive the intervention. The intervention design was equivalent to the parallel group, two-arm, superiority trial with a 1:1 allocation ratio. The end line allocation ratio was 1.27:1 due to attrition. It was found that there was statistically significant improvement in stunting (p = 0.000) and the body mass index (p = 0.003) in the intervention group and not in the control group (p = 0.351 and p = 0.511, respectively). The sensory evaluation revealed that all the millet-based menu items had high acceptability, with the highest scores for the following three items: finger millet idli, a steam cooked fermented savory cake; little and pearl millet bisi belle bath, a millet-lentil hot meal; and upma, a pearl and little millet-vegetable meal. These results suggest significant potential for millets to replace or supplement rice in school feeding programs for improved nutritional outcomes of children.

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Section: Discussionmentioning

confidence: 92%

Acceptance and Impact of Millet-Based Mid-Day Meal on the Nutritional Status of Adolescent School Going Children in a Peri Urban Region of Karnataka State in India

et al. 2019

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“…inbred lines developed at ICRISAT (Niger) from landrace and improved open-pollinated cultivars of West African origin was used in this study together with inbred line ICMB88004 as a control ( S1 Table ). Some of these inbred lines were previously characterized for grain quality [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Response to early drought stress and identification of QTLs controlling biomass production under drought in pearl millet

et al. 2018

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Pearl millet plays a major role in food security in arid and semi-arid areas of Africa and India. However, it lags behind the other cereal crops in terms of genetic improvement. The recent sequencing of its genome opens the way to the use of modern genomic tools for breeding. Our study aimed at identifying genetic components involved in early drought stress tolerance as a first step toward the development of improved pearl millet varieties or hybrids. A panel of 188 inbred lines from West Africa was phenotyped under early drought stress and well-irrigated conditions. We found a strong impact of drought stress on yield components. This impact was variable between inbred lines. We then performed an association analysis with a total of 392,493 SNPs identified using Genotyping-by-Sequencing (GBS). Correcting for genetic relatedness, genome wide association study identified QTLs for biomass production in early drought stress conditions and for stay-green trait. In particular, genes involved in the sirohaem and wax biosynthesis pathways were found to co-locate with two of these QTLs. Our results might contribute to breed pearl millet lines with improved yield under drought stress.

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“…Moreover, the putative Pennisetum glaucum (L.) R.Br. (pearl millet) PA-MRP gene has recently been described [34].…”

Section: Pa-mrp Transportersmentioning

confidence: 99%

Phytic Acid and Transporters: What Can We Learn from low phytic acid Mutants?

Cominelli

Pilu

Sparvoli

2020

Plants

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Phytic acid has two main roles in plant tissues: Storage of phosphorus and regulation of different cellular processes. From a nutritional point of view, it is considered an antinutritional compound because, being a cation chelator, its presence reduces mineral bioavailability from the diet. In recent decades, the development of low phytic acid (lpa) mutants has been an important goal for nutritional seed quality improvement, mainly in cereals and legumes. Different lpa mutations affect phytic acid biosynthetic genes. However, other lpa mutations isolated so far, affect genes coding for three classes of transporters: A specific group of ABCC type vacuolar transporters, putative sulfate transporters, and phosphate transporters. In the present review, we summarize advances in the characterization of these transporters in cereals and legumes. Particularly, we describe genes, proteins, and mutants for these different transporters, and we report data of in silico analysis aimed at identifying the putative orthologs in some other cereal and legume species. Finally, we comment on the advantage of using such types of mutants for crop biofortification and on their possible utility to unravel links between phosphorus and sulfur metabolism (phosphate and sulfate homeostasis crosstalk).

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Antinutritional factors in pearl millet grains: Phytate and goitrogens content variability and molecular characterization of genes involved in their pathways

Cited by 54 publications

References 59 publications

Acceptance and Impact of Millet-Based Mid-Day Meal on the Nutritional Status of Adolescent School Going Children in a Peri Urban Region of Karnataka State in India

Acceptance and Impact of Millet-Based Mid-Day Meal on the Nutritional Status of Adolescent School Going Children in a Peri Urban Region of Karnataka State in India

Response to early drought stress and identification of QTLs controlling biomass production under drought in pearl millet

Phytic Acid and Transporters: What Can We Learn from low phytic acid Mutants?

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