Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High‐Fat Diet with Fructose

Abstract

Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueous I. sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment with I. sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract from I. sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.

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“…In recent years, medicinal plant extracts with strong in-vivo antioxidative property have been the center of focus. It is believed that these plant extracts can prevent or protect tissues by direct antioxidative and antihyperglycaemic effects 23 . The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E was evidenced in a recent study.…”

Evaluation of Hypoglycemic and Genotoxic Effect of Polyphenolic Bark Extract from Quercus sideroxyla

“…Oxidative stress levels were evaluated by the concentration of malondialdehyde (MDA) in the liver according to Rivera-Ramírez et al [19]. The MDA concentration was calculated using the molar extinction coefficient of 1.56 × 10 −5  M −1 cm −1 .…”

Diet for Diabetics and their Limitations

“…Sweets can be high in carbohydrate and fat. Some contain saturated fats, trans-fats, and cholesterol that increase your risk of heart disease [46]. Limiting these foods will help to lose weight and keep blood glucose and blood fats under control.…”