Obesity, type II diabetes, and hyperlipidaemia, which frequently coexist and are strongly associated with oxidative stress, increase the risk of cardiovascular disease. An increase in carbohydrate intake, especially of fructose, and a high-fat diet are both factors that contribute to the development of these metabolic disorders. In recent studies carried out in diabetic rats, authors reported that Ibervillea sonorae had hypoglycaemic activity; saponins and monoglycerides present in the plant could be responsible for the effects observed. In the present study, we determined the effects of an aqueous I. sonorae extract on a murine model of obesity and hyperglycaemia, induced by a high-calorie diet, and the relationship of these effects with hepatic oxidation. A high-fat diet over a period of 8 weeks induced weight gain in the mice and increased triglycerides and blood glucose levels. Simultaneous treatment with I. sonorae aqueous extracts, at doses of 100, 200, and 400 mg/kg, decreased triglycerides and glycaemia levels, prevented an increase in body weight in a dose-dependent manner, and decreased hepatic lipid oxidation at a dose of 200 mg/kg. These data suggest that the aqueous extract from I. sonorae root prevents obesity, dyslipidaemia, and hyperglycaemia induced by a hypercaloric diet; however, high doses may induce toxicity.
Los desastres naturales y la violencia se han incrementado en el mundo, siendo la comunidad universitaria vulnerable a estas dos condiciones. Una manera de proteger y salvaguardar a los jóvenes es la educación en temas de emergencias y gestión integral del riesgo. Se trata de un estudio cuasiexperimental, descriptivo y transversal con el objetivo de realizar un estudio piloto del programa “Escuela Segura” en la comunidad estudiantil de la Universidad del Valle de Toluca utilizando como herramienta videos de diversos temas de emergencias y gestión integral del riesgo en formato Pecha-Kucha. Se capacitaron 393 estudiantes de las diferentes carreras de la universidad, y se compararon los promedios obtenidos pre y post capacitación mediante la U de Mann-Whitney y entre carreras con la prueba de Kruskal-Wallis. Todas las carreras que se imparten en esta casa de estudios mostraron una diferencia significativa en el conocimiento pre y post capacitación, con 7.28 ± 1.41 y 8.56 ± 1.02, respectivamente (p < 0.001). La carrera que más aprendió fue la de Mecatrónica y la de Mantenimiento Industrial. La educación en primeros auxilios y en gestión integral del riesgo debería ser universal y para todos los niveles de educación. El programa piloto Escuela segura, dirigido a la enseñanza de estos mediante la técnica Pecha-kucha, permite que los estudiantes universitarios adquieran los conocimientos y se generé la confianza y seguridad para dar un tratamiento inicial mientras el servicio de atención prehospitalaria acude a atender la emergencia. Por otra parte, saber que hacer antes, durante y después de un desastre beneficia a la comunidad tanto universitaria como en su entorno a construir ciudades resilientes, además de ser ellos, portadores y replicadores del mismo.
Objective. Determine risk factors for stroke in Young people under 45 years of age in the Toluca Valley. Methodology. Cross-sectional and correlational study. A questionnaire was applied to determine the risk factors for the cerebrovascular event in young adults. Two age groups of 18 to 32 and 33 to 45 years were compared, using a Mann Whitney U. Subsequently, a Pearson correlation was made and, the Odds ratio and relative risk (p <0.05) were calculated. Contribution: 2593 surveys were analyzed, 62% belong to the group of 18 to 32 years. 68.9% present some low-medium risk factors for stroke. 20% exercise more than 2:30 a.m., and only 3.4% have an adequate diet. The presence of risk factors is related to the age group, in those aged 33 to 45 years, comorbidities (overweight / obesity, hypertension, and diabetes). While lifestyle (smoking, alcoholism, and drug use) in those under 32 years of age. Those indicate that awareness and training programs should be conducted differently, according to the age group.
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