Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation, and oxidative stress: A systematic review

Gomes, Jaqueline Vieira Piovezana; Rigolon, Thaís Caroline Buttow; Souza, Mariane Sampaio da Silveira; Alvarez-Leite, Jacqueline I.; Lúcia, Ceres Mattos Della; Martino, Hércia Stampini Duarte; Rosa, Carla de Oliveira Barbosa

doi:10.1016/j.nut.2019.05.005

Cited by 63 publications

(48 citation statements)

References 48 publications

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“…Anthocyanins have shown antioxidant and anti-inflammatory properties but also positive effects in obesity and its comorbidities [ 57 , 58 , 59 , 60 ]. Several studies have demonstrated that the intake of anthocyanins by itself or of anthocyanins-rich foods such as berries is able to prevent CVD [ 61 ], to reduce body fat accumulation, to improve glucose tolerance/insulin sensitivity, to diminish the levels of fasting glucose, to control body weight in humans and rodents [ 57 , 59 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ] and to increase energy expenditure and fatty acid oxidation (FAO) in mice and humans [ 59 , 73 , 74 , 75 , 76 ]. Globally, anthocyanins and anthocyanins-rich foods are able to improve metabolic homeostasis.…”

Section: Anthocyaninsmentioning

confidence: 99%

“…They affected the adipokines secretion [ 112 ], modified the adipocytes-gene expression [ 33 , 113 , 114 ]. Moreover, anthocyanins are able to improve WAT functionality, to induce browning in WAT [ 33 , 57 , 82 , 115 ] or to increase the BAT mass or its activity [ 57 , 109 , 115 ], thus regulating energy expenditure [ 59 , 73 ]. Moreover, in WAT, anthocyanins ameliorate the obesity-associated inflammation [ 57 , 59 , 116 ].…”

Section: Anthocyaninsmentioning

confidence: 99%

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Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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Section: Anthocyaninsmentioning

confidence: 99%

Section: Anthocyaninsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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“…Anthocyanins (ACNs) are flavonoid pigments abundantly present in most red or purplish fruits and vegetables, such as blueberries, black beans, and purple cabbage (Cassidy, 2018;Zhu, 2018). They have a flavonoid structure with the C6-C3-C6 carbon skeleton, which can scavenge the reactive oxygen species and reduce the intracellular oxidative stress (Fallah et al, 2020;Gomes et al, 2019). In addition to providing antioxidant protection, they also possess a variety of biological activities, such as genetic toxicity reduction (Wang et al, 2019), eyesight improvement (Nomi et al, 2019), antitumor (Zhou et al, 2018), and anti-colitis (Zhao et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

Pan

Zhao

et al. 2020

J. Food Biochem.

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The objective of this study was to investigate the molecular interaction and complex stability of four major cow's milk (CM) proteins (α-LA, β-LG, α s1-CA, and β-CA) with cyanidin-3-O-glucoside (C3G) using computational methods. The results of molecular docking analysis revealed that hydrogen bond and hydrophobic interaction were the main binding forces to maintain the stability of the C3G-CM protein complexes. Molecular dynamics simulation results showed that all complexes except for C3Gα s1-CA were found to reach equilibrium within 50 ns of simulation. α s1-CA and β-CA switched to a more compact conformation after binding with C3G. Additionally, the radius of gyration, number of hydrogen bond, radial distribution function, and interaction energy showed that β-CA is the best C3G carrier protein among the four CM proteins. This study can provide valuable information for CM proteins to serve as C3G delivery carriers. Practical applications Anthocyanins (ACNs) are flavonoid-based pigments that play an important functional role in regulating human's health. Cow's milk (CM) proteins are the most representative protein-based carriers that can improve the short-term bioavailability and stability of ACNs. Thus, it is important to study the interactions between ACNs and CM proteins at the molecular level for the development of effective ACNs delivery carriers. Our study showed that caseins (α s1-CA and β-CA) had more hydrophobic and hydrogen-bonding sites with cyanidin-3-O-glucoside (C3G) than whey proteins using computational methods. Among the four CM proteins, β-CA was the best C3G carrier protein showing the best interaction stability with C3G. Thus, it is helpful for us to screen effective ACNs carriers from multiple protein sources by computational methods.

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“…It also confirmed that, when healthy adults consumed PW bars and crackers, the anthocyanins were rapidly absorbed and excreted, with no short-term impacts on plasma antioxidant activity or the inflammatory markers IL-6 and TNF-α (30) . In general, the majority of anthocyanin studies are limited to fruits and vegetables, as thoroughly reviewed (31,32) . Although this evidence is strong and suggests mechanisms for anti-obesity effects, and reducing oxidative stress and inflammation (31) , the data cannot be fully extrapolated to coloured grains.…”

mentioning

confidence: 99%

“…In general, the majority of anthocyanin studies are limited to fruits and vegetables, as thoroughly reviewed (31,32) . Although this evidence is strong and suggests mechanisms for anti-obesity effects, and reducing oxidative stress and inflammation (31) , the data cannot be fully extrapolated to coloured grains. The objective of the present study was to explore if 8-week consumption of products based on whole PW, compared with whole regular wheat (RW), with weight maintenance, would alter markers of inflammation, oxidative stress and lipaemia in overweight or obese individuals with chronic inflammation.…”

mentioning

confidence: 99%

Consumption of whole purple and regular wheat modestly improves metabolic markers in adults with elevated high-sensitivity C-reactive protein: a randomised, single-blind parallel-arm study

et al. 2020

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Whole grain wheat, in particular colored varieties, may have health benefits in adults with chronic metabolic disease risk factors. 29 overweight and obese adults with chronic inflammation (high sensitivity C-Reactive Protein (hs-CRP) > 1.0 mg/L) replaced four daily servings of refined grain food products with bran-enriched purple or regular whole wheat convenience bars (~ 41-45 g fiber, daily) for 8 weeks in a randomized, single-blind parallel arm study where body weight was maintained. Anthropometrics, blood markers of inflammation, oxidative stress, and lipemia and metabolites of anthocyanins and phenolic acids were compared at Days 1, 29 and 57 using repeated measures analysis of variance within groups and analysis of covariance between groups at Day 57, with Day 1 as a covariate. A significant reduction in interleukin-6 and increase in adiponectin were observed within the purple wheat (PW) group. Tumor necrosis factor (TNF)-α was lowered in both groups and ferulic acid concentration increased in the regular wheat (RW) group. Comparing between wheats, only plasma TNF-α and glucose differed significantly (P<0.05), i.e. TNF-α and glucose decreased with RW and PW, respectively. Consumption of PW or RW products showed potential to improve plasma markers of inflammation and oxidative stress in participants with evidence of chronic inflammation, with modest differences observed based on type of wheat.

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Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation, and oxidative stress: A systematic review

Cited by 63 publications

References 48 publications

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

A molecular docking and molecular dynamics simulation study on the interaction between cyanidin ‐ 3 ‐O ‐glucoside and major proteins in cow's milk

Consumption of whole purple and regular wheat modestly improves metabolic markers in adults with elevated high-sensitivity C-reactive protein: a randomised, single-blind parallel-arm study

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