Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats

Moon, Ji‐Young; Ju, Hyun; Kim, Oh Yoen; Shin, Min Jeong

doi:10.1016/j.fct.2013.05.006

Cited by 137 publications

(101 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar mechanisms have been reported with Resveratrol and Quercetin [44,45]. They can decrease lipogenesis, adipogenesis and increase apoptosis in adipose tissue.…”

Section: Discussionsupporting

confidence: 64%

Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

Cheserek

et al. 2016

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…Similar mechanisms have been reported with Resveratrol and Quercetin [44,45]. They can decrease lipogenesis, adipogenesis and increase apoptosis in adipose tissue.…”

Section: Discussionsupporting

confidence: 64%

Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

Cheserek

et al. 2016

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…A study which assessed the associations between habitual consumption of all flavonoid subclasses and weight gain among 124,086 American men and women over a period of 24 years showed higher intake of foods rich in flavonols, flavan-3-ols, anthocyanins, and flavonoid polymers may contribute to weight maintenance in adulthood after adjustment for changes in other lifestyle factors such as diet, smoking status, and physical activity [9]. Several other studies on human and rodents provide evidence that flavonoids can cause suppression of appetite [10][11][12], increase glucose uptake in muscle [13], decrease fat absorption [14], and inhibit adipogenesis [15,16].…”

Section: Introductionmentioning

confidence: 99%

Differential effects of dietary flavonoids on adipogenesis

et al. 2018

View full text Add to dashboard Cite

Propose Obesity is a fast growing epidemic worldwide. During obesity, the increase in adipose tissue mass arise from two different mechanisms, namely, hyperplasia and hypertrophy. Hyperplasia which is the increase in adipocyte number is characteristic of severe obese patients. Recently, there has been much interest in targeting adipogenesis as therapeutic strategy against obesity. Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Methods Presently, we provide a review of key studies evaluating the effects of dietary flavonoids in different stages of adipocyte development with a particular emphasis on the investigations that explore the underlying mechanisms of action of these compounds in human or animal cell lines as well as animal models. Results Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Although most of the studies reveal anti-adipogenic effect of flavonoids, some flavonoids demonstrated proadipogenic effect in mesenchymal stem cells or preadipocytes. Conclusion The anti-adipogenic effect of flavonoids is mainly via their effect on regulation of several pathways such as induction of apoptosis, suppression of key adipogenic transcription factors, activation of AMPK and Wnt pathways, inhibition of clonal expansion, and cell-cycle arrest.

show abstract

“…In 3T3-L1 cells, quercetin and quercetin-rich OPE attenuated adipogenesis [1718] and decreased liver fat accumulation in mice fed a Western diet or high-fat diet (HFD) [79]. Recently, Yang and Kim [19] demonstrated that the obesity index (% fat, BMI, waist circumstance) were significantly decreased by OPE intake for 12 weeks in obese university women.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Kim

Yim

2016

Clin Nutr Res

View full text Add to dashboard Cite

Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of a quercetin-rich onion peel extract (OPE) on the inflammatory mediators in overweight and obese women. This study was a randomized double-blind, placebo-controlled study. Thirty-seven healthy overweight and obese women were randomly assigned to two groups, and one group was given a soft capsuled OPE (100 mg quercetin/day, n = 18) and the other group a same capsuled placebo (n = 19) for 12 weeks. Fat mass was measured by bioimpendance method at baseline and after 12 weeks of intervention. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured with colorimetric assay kits. The concentrations of leptin, adiponectin, visfatin, tumor necrosis factor (TNF)-α and interleukin (IL)-4 in plasma were determined by using enzyme-linked immunosorbent assay kits. Baseline characteristics of anthropometric indicators and blood metabolic profiles were not significantly different between placebo and OPE groups. Compared with baseline value, both placebo and OPE supplementation significantly decreased the percent of body fat mass and induced plasma adiponectin levels while ALT and AST activities as well as leptin, visfatin, TNF-α, and IL-4 levels in plasma were not significantly different between two groups after 12 weeks of the supplementation. These findings suggest that 12-week supplementation of OPE do not affect modulators of systemic inflammation in overweight and obese women.

show abstract

Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats

Cited by 137 publications

References 32 publications

Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

Differential effects of dietary flavonoids on adipogenesis

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Contact Info

Product

Resources

About