Antiosteoporotic and antioxidant activities of diterpenoids from the Vietnamese soft corals Sinularia maxima and Lobophytum crassum

Abstract

Marine organisms possess bioactive potential with tremendous pharmaceutical promise. The purpose of the present study was to investigate the antioxidant (peroxyl radical-scavenging and reducing capacities) and antiosteoporotic activities of isolated constituents (1-26) from the soft corals Sinularia maxima and Lobophytum crassum on pre-osteoblastic MC3T3-E1 cells and pre-osteoclastic RAW 264.7 cells. Among the isolated compounds, 7, 9, 17, 18, and 20 (10.0 lM) exhibited significant peroxyl radical-scavenging capacity, with TE values ranging from 4.00 ± 0.14 to 9.06 ± 0.33 lM. In addition, compounds 1, 5, 7, 20, and 24 significantly stimulated the differentiation of pre-osteoblastic MC3T3-E1 cells by increasing collagen synthesis and/or mineralization functions of osteoblasts, while compounds 1, 5-8, 12, 14-22, 24, and 26 showed significant inhibition of TRAP in NFjB ligand-induced osteoclastic RAW 264.7 cells, with values ranging from 99.11 ± 1.36 to 61.54 ± 1.61 %. These results indicate that the soft corals S. maxima and L. crassum are excellent sources among the antioxidant and antiosteoporotic marine invertebrates.

Screening of Antibacterial and Antioxidant Activity from the Soft Corals Sinularia sp. and Sarcophyton sp. Origin Palu Bay, Central Sulawesi, Indonesia

“…collected from Pongok Island, Bangka Belitung, Indonesia were detected flavonoid derivative components that can act as antioxidants (Apri, Zamani, & Effendi, 2013). Twenty-four diterpenoid derivatives extracted from Sinularia maxima and Lobophytum crissum showed peroxyl radical capacityscavenging capacity from moderate to strong (Thao et al, 2015). Ethanolic extract from Sarcophyton flexuosum Tixier-Durivault collected from Kavarathi Island, Lakshadweep Islands showed increased of free radical scavenging when the extract concentration increased gradually (Byju et al, 2015).…”

Collagen of Extracellular Matrix from Marine Invertebrates and Its Medical Applications

“…However, the research for collagen on corals, especially for soft corals, has remarkably improved. Over the last several years [2,3,44,54], very interesting findings on collagen molecules have been demonstrated from soft corals. Also, a number of collagen-associated glycoproteins have been detected in soft corals [14,24,25,55,56].…”

Aktivitas Antioksidan Ekstrak Karang Lunak Asal Teluk Palu, Sulawesi Tengah, Indonesia

“…Ekstrak etanolik Heteroxenia fuscescens menunjukkan aktivitas antioksidan ringan (Mohammed et al, 2011). Senyawa turunan diterpenoid dari Sinularia maxima dan Lobophytum crissum menunjukkan kapasitas penangkapan radikal peroksil dari sedang hingga kuat (Thao et al, 2015). Ekstrak etanolik dari Sarcophyton flexuosum Tixier-Durivault dari Pulau Kavarathi, Lakshadweep m enunj ukkan peningkatan penangkapan radikal bebas saat konsentrasi ekstrak meningkat secara bertahap (Byju et al, 2015).…”