Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats

Desai, S D; Babaria, Parth; Nakarani, Madhavi; Shah, Kunal; Paranjape, Archana

doi:10.1016/j.jep.2017.01.031

Cited by 21 publications

(14 citation statements)

References 35 publications

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“…Seemly, increased U‐Ca/Cr and U‐P/Cr excretion induced by OVX were dramatically prevented in rats suffering DFPW (100 or 400 mg/kg) or RLX treatment. Additionally, OVX rats showed unchanged levels of S‐Ca and S‐P levels, indicating that balanced mineral homeostasis and lesser bone mineralization despite OVX, which was similar with the other reports for S‐Ca and S‐P levels in OVX rats . It was likely inferred that bone mass maintained in OVX rats by DFPW administration was due to enhancing bone formation and inhibiting bone resorption.…”

Section: Discussionsupporting

confidence: 87%

“…There is abundant evidence suggesting that OVX not only leads to a decrease in bone density, but also in biomechanical strength of bones . We next evaluated the effect of DFPW on biomechanical parameters of femoral diaphysis in OVX rats using three‐point bending tests.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, OVX rats showed unchanged levels of S-Ca and S-P levels, indicating that balanced mineral homeostasis and lesser bone mineralization despite OVX, which was similar with the other reports for S-Ca and S-P levels in OVX rats. 44,57 It was likely inferred that bone mass maintained in OVX rats by DFPW administration was due to enhancing bone formation and inhibiting bone resorption. There is abundant evidence suggesting that OVX not only leads to a decrease in bone density, but also in biomechanical strength of bones.…”

Section: Discussionmentioning

confidence: 99%

“…There is abundant evidence suggesting that OVX not only leads to a decrease in bone density, but also in biomechanical strength of bones. 57 We next evaluated the effect of DFPW on biomechanical parameters of femoral diaphysis in OVX rats using three-point bending tests. The same observation was observed in OVX rats, as demonstrated by the decrease in maximum load, energy, Young's modulus and maximum stress in femoral diaphysis when compared with the sham group.…”

Section: Discussionmentioning

confidence: 99%

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A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

Sun

Wei

Peng

et al. 2020

J Cellular Molecular Medi

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In the present study, a homogenous polysaccharide (DFPW) was isolated and purified from the dried rhizome of Drynaria fortunei, and its protective effect against osteoporosis was investigated in ovariectomized (OVX) rats. Histological analysis indicated that oral administration of DFPW (100 and 400 mg/kg) for 12 weeks significantly improved trabecular bone mass, as demonstrated by the increase in trabecular area, trabecular thickness and its number in OVX rats. Furthermore, the decline of bone mineral density and bone mineral content including Ca, P and Mg induced by OVX was reversed by the DFPW administration. This function was achieved by the decreased levels of the bone turnover markers, such as serum ALP, urinary deoxypyridinoline (DPD), Ca and P excretions. Besides, DFPW improved biomechanical parameters (maximum load, energy, Young's, modulus and maximum stress) to strengthen the hardness and strength femoral diaphysis in OVX rats. These results strongly suggested that DFPW might be a hopeful alternative therapeutics to treat postmenopausal osteoporosis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

Sun

Wei

Peng

et al. 2020

J Cellular Molecular Medi

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“…The expected adult population over 60 years in India by 2050 would be 315 million signifying more incidence of osteoporosis compared to 26 million in 2003 [4]. A decrease in the level estrogen is the key contributing feature for menopausal osteoporosis (MO) in women.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant enriched fraction fromPueraria tuberosaalleviates ovariectomized-induced osteoporosis in rats, and inhibits growth of breast and ovarian cancer cell linesin vitro

Satpathy

Patra

Hussain³

et al. 2020

Preprint

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Pueraria tuberosa (P. tuberosa), known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy an antioxidant enriched fraction (AEF) from the tuber extract of P. tuberosa against menopausal osteoporosis and breast and ovarian cancer cell lines. The AEF from P. tuberosa was identified by determining phenolic composition (total phenolic and flavonoid amount). Antioxidant property (in vitro assays) was also carried out followed by analysis of the AEF for its antiosteoporotic and anticancer potentials. Antiosteoporotic activity of AEF was investigated in ovariectomy-induced osteoporosis in rats and in vitro anticancer activity by MTT assay. Also, the GC/MS analysis of AEF was performed to determine various phytoconstituents. A docking analysis was performed to verify the interaction of bioactive molecules with estrogen receptors (ERs). Ethyl acetate fraction of the mother extract was proved as the AEF. AEF significantly improved various biomechanical and biochemical parameters in a dose dependent manner in the ovariectomized animals. AEF also controlled the increased body weight and decreased uterus weight following ovariectomy. Histopathology of femur revealed the restoration of typical bone structure and trabecular width in ovariectomized animals after AEF and raloxifene treatment. AEF also exhibited in vitro cytotoxicity in breast (MCF-7 and MDA-MB-231) and ovarian (SKOV-3) cancer cells. Further, genistein and daidzein exhibited a high affinity towards both estrogen receptors (α and β) in docking study revealing the probable mechanism of the antiosteoporotic activity. GC/MS analysis confirmed the presence of bioactive molecules such as stigmasterol, β-sitosterol, and stigmasta-3,5-dien-7-one. The observations of this study vindicate the potency of AEF from P. tuberosa in the treatment of menopausal osteoporosis and cancer.

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Cultural, Practical, and Socio-Economic Importance of Edible Medicinal Plants Native to Central India

Neupane

Yadav

Verma

2022

Edible Plants in Health and Diseases

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Antiosteoporotic effect of Hemidesmus indicus Linn. on ovariectomised rats

Cited by 21 publications

References 35 publications

A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)‐induced osteoporosis in rats

Antioxidant enriched fraction fromPueraria tuberosaalleviates ovariectomized-induced osteoporosis in rats, and inhibits growth of breast and ovarian cancer cell linesin vitro

Cultural, Practical, and Socio-Economic Importance of Edible Medicinal Plants Native to Central India

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