Antiovary antibodies, repeated attempts, and outcome of in vitro fertilization

IgG, IgA and IgM Antibodies against FSH: Serological Markers of Pathogenic Autoimmunity or of Normal Immunoregulation?

“…Enzyme‐linked immunosorbent assay (ELISA) using crude human ovary extract, has been used to detect AOA in patients undergoing IVF procedures 4 . Some of AOA‐positive IVF patients also presented autoantibodies against FSH, as shown previously by Gobert et al 8 The FSH and its signaling system play a central role in the normal reproductive function, regulating follicular maturation and ovulation 9 .…”

“…Autoimmune mechanisms are involved in such infertility disorders as endometriosis and ovarian failure, and may be responsible for the pathophysiology of pre‐eclampsia or spontaneous abortions 1,2 . Antiovary antibodies (AOA) are associated primarily with premature ovarian failure and unexplained infertility 2,3 and have been found to be markers of autoimmune disorders causing the poor outcome of in vitro fertilization (IVF) 4,5 . As a reference method, indirect immunofluorescence on human or primate frozen ovary sections and the specific labeling of internal theca cells has been used to detect AOA 6 .…”

HSP90 Antibodies: A Detrimental Factor Responsible for Ovarian Dysfunction

“…Under certain pathological conditions, the immune system deviates from its traditional role and leads to the destruction of self‐proteins causing autoimmunity. Ovary is also a target of autoimmune attack that causes pathological conditions like Premature Ovarian Failure/Premature Ovarian Insufficiency (POF/POI) and repeated in vitro fertilization–embryo transfer (IVF‐ET) failures . Of the multiple causal factors associated with these conditions, autoimmunity accounts for 20–30% cases of POI and 26% cases of IVF‐ET failure …”

Antibodies against Granulosa Luteinized Cells and their Targets in Women Attending IVF Program

“…Anti‐ovarian antibodies (AOA) have been associated with premature ovarian failure (POF), with adrenal and polyglandular autoimmune disorders 1–6 and their presence was considered as a suitable marker for the identification of the immunological mechanism in POF 5 . In other studies, AOA have been suspected to be a possible cause of infertility and unsuccessful in vitro fertilization–embryo transfer (IVF–ET) 7–12 . The higher prevalence of AOA in patients with failed fertilization and implantation supports the assumption of their adverse effect on reproduction processes 13–15 .…”