Antioxidant action of several<i>β</i>‐adrenergic blockers and related compounds

Aboul‐Enein, H. Y.; Kruk, Irena; Lichszteld, Krzysztof

doi:10.1080/02772249909358668

Cited by 5 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is growing interest in finding antioxidants that can scavenge excessive ROS from living organisms (24). Recently, we reported the antioxidant properties of several α-adrenergic blockers and related compounds (25) as well as 4-flavonil-1,4-dihydropyridine derivatives (26). The present study was undertaken to elucidate the ROS scavenging activity of the novel series of indol-2 and 3-carboxamides.…”

Section: Discussionmentioning

confidence: 98%

Scavenging of reactive oxygen species by N‐substituted indole‐2 and 3‐carboxamides

et al. 2004

View full text Add to dashboard Cite

Indole-2 and 3-carboxamides (IDs) are proposed to be selective cyclooxygenase inhibitors. Since cyclooxygenase-1 may be involved in reactive oxygen species (ROS) production, we hypothesize that these indole derivatives have antioxidative properties. We have employed chemiluminescence (CL) and electron spin resonance (ESR) spin trapping to examine this hypothesis. We report here the results of a study of reactivity of 10 selected indole derivatives towards ROS. The following generators of ROS were applied: potassium superoxide (KO2) as a source of superoxide radicals (O2 (.-)), the Fenton reaction (Co-EDTA/H2O2) for hydroxyl radicals (HO.), and a mixture of alkaline aqueous H2O2 and acetonitrile for singlet oxygen (1O2). Hydroxyl radicals were detected as 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) spin adduct, whereas 2,2,6,6-tetramethyl-piperidine (TEMP) was used as a detector of 1O2. Using the Fenton reaction, 0.5 mmol/L IDs were found to inhibit DMPO-.OH radical formation in the range 7-37%. Furthermore the tested compounds containing the thiazolyl group also inhibited the 1O2-dependent TEMPO radical, generated in the acetonitrile + H2O2 system. About 20% inhibition was obtained in the presence of 0.5 mmol/L IDs. 1 mmol/L IDs caused an approximately 13-70% decrease in the CL sum from the O2 (.-) generating system (1 mmol/L). The aim of this paper is to evaluate these indole derivatives as antioxidants and their abilities to scavenge ROS.

show abstract

Section: Discussionmentioning

confidence: 98%

Scavenging of reactive oxygen species by N‐substituted indole‐2 and 3‐carboxamides

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In the search for alternative natural antioxidants with potential antioxidant activity, limited attention has been directed toward the Nigella sativa L. which is an annual herbaceous plant belonging to the Ranunculaceae family (Atta, ). The oil of Nigella sativa L. is known to possess strong antioxidant activities (Aboul‐Enein, Kruk, & Lichszteld, ) which may be caused by phenolic compounds (Burtis & Bucar, ). Seeds of Nigella sativa L. are rich in many important nutrients that have a very positive effect on human health.…”

Section: Introductionmentioning

confidence: 99%

The effect of addition of Nigella sativa L. oil on the quality and shelf life of pork patties

Wojtasik‐Kalinowska

Guzek

Brodowska

et al. 2017

J Food Process Preserv

View full text Add to dashboard Cite

The aim of the study was to determine the effect of the addition of different levels of Nigella sativa L. oil to minced pork on the quality and shelf life of pork patties. During the studies lipid oxidation, fatty acids profile, color as well as a total number of aerobic bacteria of raw pork patties stored under refrigeration conditions in the period of 8 days were determinated. Furthermore, sensory evaluation of roasted patties were performed. Results showed that the addition of Nigella sativa L. oil to pork has an impact on the properties of patties. The radical scavering activity of Nigella sativa L. oil was also indicated. It can be concluded that there is the potential of using Nigella sativa L. oil in the development of functional pork products with favorable volatile compounds and beneficial for people fatty acids profile. Practical applications Synthetic antioxidants have been used to prevent lipid oxidation in meat. However, the addition of synthetic antioxidants to food products has been restricted because of possible of health risks and toxicity. Therefore, there is an increasing interest in the addition of natural antioxidants to prevent oxidative processes in meat products. The study presents the effect of Nigella sativa L. on quality changes of pork patties under refrigerated conditions. The work has shown the positive effect of Nigella sativa L. oil on fatty acids profile in raw pork patties and volatile compounds profile in roasted pork patties. Samples with the addition of oil characterized up to 60% slower oxidative process of lipids than control samples; simultaneously without a negative changes of sensory properties.

show abstract

Effect of psoralens on Fenton‐like reaction generating reactive oxygen species

et al. 2002

View full text Add to dashboard Cite

Psoralens (psoralen, khellin, and visnagin) in 1 mM doses were shown to enhance the generation of reactive oxygen species, such as the hydroxyl radical (HO ⅐ ), the superoxide anion radical (O 2 Ϫ • ), and singlet oxygen ( 1 O 2 ), from the system generating chemiluminescence (CL), as well as free radicals in the absence of light. The system that generated CL was made up of CoCl 2 and H 2 O 2 . Incubation of psoralens in 0.2 mM doses with the generating system showed that only 8-methoxypsoralen and khellin have antioxidative effects. Antioxidative effects were also observed in the case of visnagin but in low concentration (0.05 mM). High doses of psoralens (1 mM) showed prooxidative effects. Measurements were done using a deoxyribose assay, the CL method, and spin-trapping with 5,5-dimethyl-1-pyrroline-N-oxide and 2,2,6,6-tetramethylpiperidine combined with electron spin resonance spectroscopy and spectrophotometry methods.

show abstract

Antioxidant action of severalβ‐adrenergic blockers and related compounds

Cited by 5 publications

References 20 publications

Scavenging of reactive oxygen species by N‐substituted indole‐2 and 3‐carboxamides

Scavenging of reactive oxygen species by N‐substituted indole‐2 and 3‐carboxamides

The effect of addition of Nigella sativa L. oil on the quality and shelf life of pork patties

Effect of psoralens on Fenton‐like reaction generating reactive oxygen species

Contact Info

Product

Resources

About