Antioxidant activities and contents of flavonoids and phenolic acids of Talinum triangulare extracts and their immunomodulatory effects

Abstract

In this study, leaves and stems of Talinum triangulare were sequentially extracted with phosphate buffer solution to obtain PTL and PTS (phosphate buffered extracts of T. triangulare leaves and stems), with 75% ethanol to obtained ETL and ETS (ethanol extracts of T. triangulare leaves and stems), or with 90°C boiling water to obtain WTL and WTS (water extracts of T. triangulare leaves and stems). We investigated the antioxidant activities of various T. triangulare extracts, analyzed the extracts' stimulations on human mononuclear cell (MNC) growth and secretion of cytokines (interleukin-1 beta, interferon-γ, and tumor necrosis factor-α) and nitric oxide, and then assayed their subsequent inhibitions on human leukemic U937 cell growth. Results indicated that extracts of T. triangulare showed significant antioxidant activities. Among these extracts, WTS showed the highest stimulatory effect on human MNC growth. The secretion levels of interleukin-1 beta, interferon-γ, and tumor necrosis factor-α in the conditioned medium, wherein human MNC was treated with 500 μg/mL WTS for 72 hours, were 1275, 859, and 2222 pg/mL, respectively. All conditioned media obtained from human MNCs cultured with various T. triangulare extracts showed significant inhibition against U937 cell growth of over 40%. These results suggest that T. triangulare extracts may be used in health foods for their immunomodulatory potential.

Effects of Talinum triangulare leaf flavonoid extract on streptozotocin‐induced hyperglycemia and associated complications in rats

“…The ethanolic extract of Talinum triangulare leaves has been reported to inhibit the production of free radical that often potentiate membrane lipid peroxidation (Adefegha & Oboh, 2011;Liao, Chai, Wang, Chen, & Tsai, 2015). Similar to that, the methanolic extract of Talinum portulacifolium leaves was also reported to inhibit intestinal alpha-glucosidase activity in rats (Thalapaneni et al, 2008) while leave extracts of T. portulacifolium obtained with hexane and water were reported to show antihyperglycemic and antioxidant effects (Babu et al, 2009).…”

Comparative Assessment of Haematopoietic Potential of Ethanolic Extract of Telfairia occidentalis and Talinum triangulare Leaves in Wistar Rats

“…This might be due to the presence of phytochemical content and antioxidant potential of the T. occidentalis leaves as reported by Airaodion., et al [9]. Similarly, Swarna and Ravindhran [36] and Liao., et al [37] have reported that T. triangulare leaves are rich in phytochemicals and antioxidants respectively. Furthermore, Airaodion., et al [28] had previously reported that T. triangulare leaves acts as preventive and therapeutic agent against ethanol-induced oxidative stress in Wistar rats due to its antioxidant potential.…”

<i>Astraea lobata</i> (L) Klotzsch (Euphorbiaceae): An ethnopharmacological review

“…Therefore, it can be concluded that the increased lipid peroxidation might be one of the factors causing the defect in vascular endothelial growth factor expression and finally producing the impairment in the wound-healing process. These antioxidant activities demonstrated by A. lobata extracts are probably due to flavonoids and phenolics that are common in the species [27,33] and also known to exhibit antioxidant activities [40].…”