Comparative Assessment of Haematopoietic Potential of Ethanolic Extract of  Telfairia occidentalis and Talinum triangulare Leaves in Wistar Rats

Airaodion, Augustine I.; Ogbuagu, Uloaku; Ekenjoku, John A.; Ogbuagu, Emmanuel O.

doi:10.31080/asnh.2019.03.0443

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…On the other hand, excessive ROS exposure causes oxidative stress and inhibits wound healing. 9 To the best of our knowledge, there are no available studies about the effect of gemcitabine anticancer on oral wound healing. The purpose of this research was to examine the effects of intraperitoneal injection of gemcitabine at a therapeutic dose on the healing of buccal mucosa wounds from a histological and biochemical standpoint.…”

Section: Introductionmentioning

confidence: 99%

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Naser¹,

Hamed²,

Taqa³

2022

J Oral Res

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Background: Numerous types of cancer are of substantial medical and social concern, posing a major challenge to modern medicine. Chemotherapeutic drugs include the use of nucleosides, which are composed of nucleic acid and sugar. Objective: This study aims to assess the impact of systemic chemotherapeutic drugs at a therapeutic dose on the wound healing process of the oral mucosa. Material and Methods: 30 healthy rats were randomly divided into two main groups based on the study material, 15 rats in each group. Group A (control) was given a single dose of normal saline (1ml/kg, intraperitoneal), and Group B (study) a single injection of gemcitabine (50 mg /Kg, intraperitoneal). After anesthesia, a full-thickness soft tissue incision (0.5 cm length) on the right side of the buccal mucosa was made in the animals of both groups. Each group was subdivided according to the time of sacrifice into 3, 7, 14 days after surgery, at the end of the experimental periods, specimens were collected for histopathological study, and samples of blood were obtained from retro-orbital venous plexus and collected in microfuge tubes and levels of antioxidant enzymes were measured by ELISA. The data were analyzed statistically at a 0.05 level of significance. Results: Gemcitabine delayed the onset of wound cascade (inflammation and re-epithelization) which lead to worsening healing of the oral tissue; it also resulted in a decrease of the antioxidant activity of glutathione peroxidase and catalase, as well as activated caspase 3, which induces cell apoptosis. Conclusion: Gemcitabine showed negative feedback on oral tissue wound healing through delayed wound healing cascade and by inducing apoptosis.

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Section: Introductionmentioning

confidence: 99%

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Naser¹,

Hamed²,

Taqa³

2022

J Oral Res

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Hepato-Protective Effect of Telfaria occidentalis (Ugwu) Leaves Supplementation in Paracetamol Induced-Toxicity in Rats

M.M.¹,

I.O.²,

Adigun³

et al. 2022

African Journal of Biology and Medical Research

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The hepato-protective effect of Telfaria occidentalis leaves supplementation on paracetamol induced liver toxicity in wistar rats was investigated. A total of forty Wistar (female and male) rats weighing between 150-250g were selected for the study. The animals were randomly divided into four groups of five animals each. Animals in group 1 and 2 received standard chow only while animals in group 3 and 4 received 5% and 10% T. occidentalis supplementation in their feed respectively for six weeks. Group 2, 3 and 4 were administered 3000 mg/kg bodyweight of paracetamol intraperitoneally after six weeks. The animals were sacrificed after 24hours of induction and the liver was harvested for analysis. Alanine transaminase, Aspartate Transaminase and Alkaline Phosphatase, total protein, total bilirubin and direct bilirubin were measured in the liver homogenate following standard methods. A significant decrease in the level of ALT, AST and ALP, Bilirubin and increased total protein in group 3 and 4 were observed when compared with group 2. This study showed that T. occidentalis leaves possess protective potential on the liver when supplemented in the diet thereby preventing deleterious effects that might arose from paracetamol overdose or overuse. The study concluded that the protective effect of the leaves on the liver is percentage supplementation (dose) dependent.

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Comparative Assessment of Haematopoietic Potential of Ethanolic Extract of Telfairia occidentalis and Talinum triangulare Leaves in Wistar Rats

Cited by 2 publications

References 17 publications

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Does systemic anticancer gemcitabine compromise oral soft tissue wound healing?

Hepato-Protective Effect of Telfaria occidentalis (Ugwu) Leaves Supplementation in Paracetamol Induced-Toxicity in Rats

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