Antioxidant Activities of Genistein: A Review

Burhan, Mawarni; Oktavia, Sri; Fauziah, Fitra

doi:10.47760/ijpsm.2020.v05i10.001

Cited by 2 publications

(2 citation statements)

References 20 publications

(21 reference statements)

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“…Our study also demonstrated that high-carbohydrate and high-fat diets cause oxidative damage to the liver, similar to previous findings on fish [12,16,48,[65][66][67]. Genistein supplementation can improve antioxidant status and enhance the oxidant defense capability [68]. This is consistent with the results in golden pompano (Trachinotus ovatus) [19], juvenile grass carp [69], and mammals such as young piglets [70].…”

Section: Discussionsupporting

confidence: 92%

Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp (Cyprinus carpio L.) Fed with High-Carbohydrate and High-Fat Diets

Yang

Zhao

et al. 2023

Aquaculture Nutrition

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A 56-day feeding trial was conducted to investigate the effects of genistein on growth, lipid metabolism, antioxidant capacity, and immunity of common carp fed with high-carbohydrate or high-fat diets. Five diets were used to feed fish: control diet (5% fat; CO), high-fat diet (11% fat; HF), high-carbohydrate diet (45% carbohydrate; HC), and HF or HC diet with 500 mg/kg genistein (FG or CG). Results showed that final body weight (FW) and specific growth rate (SGR) were significantly reduced, but the supplementation with genistein resulted in higher values of FW and SGR than the HF or HC group. Both high carbohydrate and high fat belong to high-energy diets, which may promote lipid deposition. Genistein obviously decreased liver triglyceride (TG) content and alleviated hepatic fat vacuolation in the HF and HC groups. The expression of lipid metabolism genes (cpt-1 and atgl) was markedly higher in the FG group than in the HF group. The lipid synthesis-related genes (fas, acc, and pparγ) were elevated in high-energy diets but recovered to the control level or reduced after genistein treatments. With respect to fatty acid transporter genes, fatp increased in the FG group, and cd36 increased in the CG group. Furthermore, the antioxidant and immune indexes, such as total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), acid phosphatase (ACP), and lysozyme (LZM) activities, were decreased, while malonate aldehyde (MDA) content, activities of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were enhanced in the HF and HC groups. The antioxidant and immunity values could be ameliorated by treatment with genistein. Moreover, the transcript levels of antioxidant-related genes (cat, gr, and nrf2) in the liver and anti-inflammatory factors (tgf-β and il-10) and lyz in the head kidney tissue were promoted, although the expression levels of proinflammatory factors (tnf-α and il-6) declined in the genistein supplementation group, which confirmed the antioxidant and immune-enhancing effects of genistein. Therefore, 500 mg/kg genistein could ameliorate the negative effects of high-energy diets on immunity.

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Section: Discussionsupporting

confidence: 92%

Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp (Cyprinus carpio L.) Fed with High-Carbohydrate and High-Fat Diets

Yang

Zhao

et al. 2023

Aquaculture Nutrition

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“…Phytoestrogens are polyphenolic molecules that resemble 17-estradiol in structure and function (15).GE is a widely used plant hormone that has a structure similar to estrogen's, allowing it to perform the same functions as estrogen (40), its ability to fulfill the stimulating and inhibiting roles of ES through its interaction with the alpha and beta ES receptors, as well as its safe use without side effects (28). Additionally, it performs as an antioxidant (8). According to Kasim et al (20), GE in drinking water caused a significant increase in estrogen levels.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Genistein Implantation on Offspring Sex Ratios and Their Relation to Estrogen Levels in the Blood of Iraqi Chickens

R. A. S. Al-Ghurairi,

W. Kh. A. Al – Hayani,

Y. M. A. Maaeni

2023

Iraqi J. Agric. Sci.

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This study was carried out at the Poultry Research Station / Agricultural Research Department / Ministry of Agriculture, to investigate the effects of implanting genistein (GE) for the period of 1/February/2021 to 16/August/2021. into Iraqi local chickens at various ages on primary (PSF) and secondary (SSF) sex ratios of female, fertility (FE), and hatchability (HA) traits. At the age of 12 weeks, 100 hens and 20 roosters of Iraqi local chickens from the Poultry Research Station were used in this study. After numbering the hens, the birds were housed in individual cages and divided into four treatments (each with 25 chickens) as follows: T1: none implantation; T2, T3, and T4: implantation of 10 mg GE /kg weight at 14, 18, and 22 weeks of age, respectively. The experiment was divided into three periods, each for 28 weeks, and then rated according to the overall average and all of the traits studied. The results showed that implanting GE into hens had a positive influence on FE, PSF, SSF, and estrogen level (ES), especially at 18 weeks of age. There were also significant correlations between traits and ES in hens’ blood. It was also shown that the regression of most traits on ES is first order linear. As a result, it can be concluded that GE has a positive effect on ES, PSF, SSF, with the possibility of predicting sex ratios and sex offspring based on estrogen levels in the blood, and that implantation at 18 weeks of age has produced great results.

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Antioxidant Activities of Genistein: A Review

Cited by 2 publications

References 20 publications

Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp (Cyprinus carpio L.) Fed with High-Carbohydrate and High-Fat Diets

Effects of Genistein on Lipid Metabolism, Antioxidant Activity, and Immunity of Common Carp (Cyprinus carpio L.) Fed with High-Carbohydrate and High-Fat Diets

The Influence of Genistein Implantation on Offspring Sex Ratios and Their Relation to Estrogen Levels in the Blood of Iraqi Chickens

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