Background: Inflammation is a natural reaction that the body has when exposed to physical damage. Inflammation in numerous organs implies atherosclerosis, diabetes, dermatitis, arthritis, obesity, and cancer. The review's objective was to summarize the currently known eriocitrin's anti-inflammatory effects. Methods:  A review was conducted on a study of the anti-inflammatory effects of eriocitrin conducted from January 2010 to April 2021. Results: Based on eligibility criteria, six studies were included in this study consisting of in vitro and in vivo studies. Some pharmacological studies have suggested that eriocitrin has the potential to treat diseases involving inflammatory responses. Nitric Oxide (NO), IL-1β, IL-6, IL-8, TNF-α, NF-κB, MPO, MAPK, and MMP-9 secretion were reduced by eriocitrin, inhibiting cell apoptosis, and the production of pro-inflammatory cytokines, but increases the content of IL-10, Nrf2, DUSP14, HO-1, and NQ01. Conclusions: Eriocitrin has been shown to have anti-inflammatory effects in both in vitro and in vivo studies. Keywords: eriocitrin; flavonoids; inflammation

Inflammation occurs because of a response to tissue injury, cell death, cancer, ischemia, and degeneration. Uncaria gambir is one of the pharmacological solutions in overcoming inflammation. U. gambir has traditionally been used as a febrifuge, pain reliever, anti-inflammatory, antioxidant, and burn wound healing. The purpose of this paper is to present knowledge of the phytochemical and anti-inflammatory properties of U. gambir. This review provides literature evidence from 2011 to 2021. Three search sources were used as literature review sources (Pub Med, Science Direct, and Google Scholar). 13 articles in this review were based on our eligibility criteria. Pharmacological studies reported that U. gambir had been shown to have anti-inflammatory activity by reducing the volume of edema, inhibiting the enzymes COX-1, COX-2, 5-LOX, and iNOS. The phytochemical compounds contained in U. gambir were flavonoids, phenolics, polyphenols, catechins, spiroxylopropane rings, proanthocyanidins, alkaloids, epicatechins, and caffeic acid, which were distributed in leaves, trunk, bark, shoots, stems, and gambir.

Traditional medicine was becoming more popular as a component of complementary and alternative medicine around the world. The ability to provide information on the pharmacological effects of plants requires a thorough understanding of the chemical components found in plants. One of the chemical compounds reported having pharmacological activity was punicalagin. Punicalagin was a polyphenol compound found in Punica granatum, Lafoensia pacari, and genus Terminalia. This review provides information on the pharmacological activities of punicalagin. The bibliographic databases used as the sources of information were PubMed, Google Scholar, and ScienceDirect. The pharmacological activities of punicalagin have been reported as anticancer, antioxidant, hepatoprotective, antimicrobial, antivirus, neuroprotective, antiinflammation, gastroprotective, pre-eclampsia, antidiabetic, and anti hyperlipidemia. Keywords: Punicalagin, Antioxidant, Anticancer, Antivirus.

Background: Inflammation is part of the biological response that exists in vascular tissue to harmful stimulation. Using medicinal plants can help to treat inflammation. Etlingera elatior (Jack) RM Sm. is one of the medicinal plants. Objective: The review aims to present information from some research about the phytochemical and antiinflammatory activity of Etlingera elatior (Jack) RM Sm. Methods: The review provides evidence in the literature for the phytochemical and antiinflammatory activity of Etlingera elatior (Jack) RM Sm. from 2010-2021. The bibliographic databases were used as the primary sources of information (Google Scholar, ScienceDirect, and PubMed). The keywords in this search were "Phytochemical or Phytochemistry" and "Etlingera elatior (Jack) RM Sm. or Nicolaia speciosa Horan" and "Anti-inflammatory or Anti Inflammatory." Five studies were included in this review according to the required criteria. Results: Phytochemical compounds contained in Etlingera elatior (Jack) RM Sm. dominated by flavonoids, saponins, tannins, terpenoids phenolic, and volatile oils which are widely distributed in leaves, flowers, stems, and rhizomes. Pharmacological studies reported that Etlingera elatior (Jack) RM Sm. shown anti-inflammatory activity by inhibiting regulation of NF-κB-p65 expression. It can reduce carrageenan-induced edema in the soles of rat's feet and stabilize erythrocyte membranes. Conclusion: Etlingera elatior (Jack) RM Sm. is the potential medicinal plant to develop as anti-inflammatory therapy.

Hiperurisemia merupakan keadaan dimana terjadi peningkatan kadar asam urat darah di atas normal. Daun belimbing wuluh (Averrhoa bilimbi L.) digunakan secara tradisional oleh masyarakat untuk mengobati hiperurisemia. Penelitian ini bertujuan untuk mengetahui aktivitas antihiperurisemia fraksi ekstrak etanol daun belimbing wuluh yang terdiri dari fraksi air, fraksi etil asetat dan fraksi n-heksan pada mencit hiperurisemia. Mencit terdiri dari 6 kelompok (normal, kontrol negatif, kontrol positif (allopurinol), fraksi n-heksan, fraksi air, dan fraksi etil asetat dosis 100 mg/kgBB). Mencit diinduksi hiperurisemia dengan makanan diet purin tinggi (MDPT). Fraksi diberikan secara peroral satu kali sehari selama 14 hari. Kadar asam urat diukur pada hari ke-15 dengan fotometer klinik. Hasil penelitian menunjukkan bahwa pemberian fraksi ekstrak etanol daun belimbing wuluh (Averrhoa bilimbi L.) yang terdiri dari fraksi n-heksan, fraksi air, dan fraksi etil asetat dapat menurunkan kadar asam urat mencit hiperurisemia secara signifikan (sig < 0,05), dimana aktifitas antihiperurisemia yang paling baik ditunjukkan oleh fraksi etil asetat daun belimbing wuluh.