AKTIVITAS ANTIHIPERURISEMIA FRAKSI EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA MENCIT HIPERURISEMIA

Fauziah, Fitra; Witari, Diah; Kardela, Widya

doi:10.36341/jops.v4i2.1352

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Meanwhile, in vitro research states that A.bilimbi leaves extract promoted adipogenesis in much the same way as a PPAR gamma agonist did (Lau et al, 2019). This study will continue the research of ethanol extract A.bilimbi leaves conducted by Fauziah et al, (2018), the ethyl acetate fraction of A.bilimbi leaves by Fauziah et al, (2020) and to determine the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides. The ethyl acetate fraction was used in this study because ethyl acetate was able to dissolve certain semi-polar alkaloids and flavonoid compounds…”

Section: Introductionmentioning

confidence: 57%

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Abdillah

Fauziah²,

Lestari³

et al. 2022

Pharmaciana

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Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15 th day, the normal group was given vehicle (Na CMC 5%), negative control group was given highfat feed, a positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animals were treated until the 28 th day. On day 29, the blood were taken to determine the total cholesterol andtriglyceride levels using clinical photometer 5010 v5+. The data were statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).

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Section: Introductionmentioning

confidence: 57%

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Abdillah

Fauziah²,

Lestari³

et al. 2022

Pharmaciana

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“…Berdasarkan penelitian sebelumnya juga diketahui bahwa belimbing wuluh juga memiliki aktifitas antihiperurisemia. Fraksi etil asetat dari 1,033 ± 0,2082^a 6900,00 ± 589,491^b Fraksi Etil Asetat Dosis 100 mg/kg BB 2,900 ± 0,2646^c 13233,33 ± 652,559^d Fraksi Etil Asetat Dosis 200 mg/kg BB 1,333 ± 0,5132^a 10483,33 ± 1239,287^c Fraksi Etil Asetat Dosis 400 mg/kg BB 1,300 ± 0,1732^a 7600,00 ± 522,015^b ekstrak etanol daun belimbing wuluh menunjukkan aktifitas antihiperurisemia yang paling baik dibandingkan fraksi air dan fraksi n-heksan (Fauziah et al, 2020). Oleh karena itu, penelitian ini dilanjutkan untuk menelusuri aktifitas antihiperurisemia fraksi etil asetat daun belimbing wuluh dengan beberapa variasi dosis dengan parameter pengamatan kadar asam urat darah dan jumlah sel leukosit.…”

Section: Pendahuluanunclassified

Antihyperuricemia Activity of the Ethyl Acetate Fraction of Bilimbi Leaves (Averrhoa bilimbi L.)

Fauziah¹,

Ifora

Sari

2021

jfu

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Hyperuricemia is a condition where there is an increase in uric acid levels above normal. An increase in the number of leukocytes is also a biological marker of hyperuricemia. The leaves of bilimbi (Averrhoa bilimbi L.) are one of the traditional medicinal plants which contain alkaloids, tannins, steroids, and flavonoid compounds. Flavonoid compounds are thought to inhibit the formation of uric acid in the body. This study investigates the antihyperuricemia activity of the ethyl acetate fraction of bilimbi leaves. The animals were male white mice grouped into six groups: the normal group, negative control, positive control (allopurinol), and the group was given the ethyl acetate fraction of bilimbi leaves at doses of 100, 200, and 400 mg/kg BW. Hyperuricemia induction is by giving high-purine diets and potassium oxonate. The results showed that the variation of the ethyl acetate fraction of bilimbi leaves significantly reduce uric acid levels and the number of leukocyte cells (sig <0.05). Giving ethyl acetate fraction at a dose of 400 mg/kg BW showed the best reduction in uric acid and leukocyte levels.

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In vitro Antiplatelet Activities of Aqueous Extract of Garlic (Allium sativum) and black Garlic in Human Blood

Agustina

Gan

Yuliatiq

et al. 2022

RJPT

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Coronary heart disease is one of the deadliest cardiovascular disease in the world. Recent studies have shown an increase in aspirin resistance as a gold standard therapy causing recurrent heart attacks. Antiplatelet of natural resources thus need to be explored. Garlic (Allium sativum) is known to be effective as an antiplatelet, but the problem arose after consuming garlic prolonged is the presence of unpleasant breath and body odor which reduces patient compliance in therapy. Black Garlic is a product made of garlic which tastes delicious and does not smell pungent like raw garlic. There has been no study of Black Garlic as an antiplatelet before. The aim of this research was to determine the antiplatelet activities of aqueous extract of garlic (AEG) and Black Garlic (AEBG) and to evaluate their differences in human blood in vitro. This research was designed to be experimental posttest only, which was performed in 10 groups, namely the vehicle controls, positive controls, as well as the concentration groups of AEG and AEBG (each 1-4μg/μL). The antiplatelet activity was tested using the Born method, which measured the plasma uptake before and after induced with Papain. Evaluation was done by calculating the percent inhibition of platelet aggregation of the concentration groups relative to vehicle controls. The results showed that both AEG and AEBG have antiplatelet activities ([H=16.664; 5 df; p=0.005] and [H=16.225; 5 df; p=0.006] respectively). The inhibition of platelet aggregation is also shown to be significantly different in both samples [H=21.693; 7 d.f; p=0.003].

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AKTIVITAS ANTIHIPERURISEMIA FRAKSI EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA MENCIT HIPERURISEMIA

Cited by 3 publications

References 5 publications

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model

Antihyperuricemia Activity of the Ethyl Acetate Fraction of Bilimbi Leaves (Averrhoa bilimbi L.)

In vitro Antiplatelet Activities of Aqueous Extract of Garlic (Allium sativum) and black Garlic in Human Blood

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