Antioxidant Activities of Processed Deoduck (Codonopsis lanceolata) Extracts

Jeon, Sang-Min; Kim, Soyoung; Kim, In‐Hye; Go, Jeong-Sook; Kim, Haeng-Ran; Jeong, Jae-Youn; Lee, Hyeon-Yong; Park, Dong-Sik

doi:10.3746/jkfn.2013.42.6.924

Cited by 22 publications

(5 citation statements)

References 45 publications

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“…Sang-Min Jeon và cộng sự có nghiên cứu về tác dụng chống oxy hóa in vitro của trên 1 loài khác của chi Codonopsis là Codonopsis lanceolata. Kết quả cho thấy chiết cao áp và hấp bằng quá trình lên men có hiệu quả hơn so với cách chiết xuất thông thường [15]. Chang-Seon Yoo và Sung-Jin Kim cũng chứng minh được dịch chiết MeOH của Codonopsis pilosula có tác dụng chống oxy hóa in vivo rõ rệt thông qua ức chế quá trình oxy hóa iNOS và protein [16].…”

Section: Bàn Luậnunclassified

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Thuy¹,

Trang²,

Bình³

et al. 2020

MPS

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This study aims to evaluate the antioxidant ability and α-glucosidase inhibitory activities of Codonopsisjavanica extract to elucidate its mechanism in the treatment of diabetes type 2. The roots of Codonopsisjavanica were extracted with ethanol solvents and fractionated with n-hexane, ethyl acetate and butanol solvents. The total extract and the fractions were evaluated for free radical scavenging by 2.2-diphenyl-1-picrylhydrazyl method and α-glucosidase inhibitory activity in vitro. The study results show that ethyl acetate fraction from Codonopsisjavanica roots had the strongest antioxidant activity with a value of IC50 of 80.6 ± 2.8 µg/mL and a strong α-glucosidase enzyme inhibitory activity with a value of IC50 of 80.4 ± 5 µg/mL. These data suggest that ethyl acetate fraction from Codonopsisjavanica roots may have potential for the prevention and treatment of diabetes type 2. Keywords Codonopsisjavanica, diabetes type 2, α-glucosidase, antioxidant ability, fraction. References [1] B.Y. Te. Guidelines for the diagnosis and treatment of type 2 diabetes, 2017.[2] U. Asmat, K. Abad, K. Ismail. Diabetes mellitus and oxidative stress-A concise review. Saudi pharmaceutical journal 24(5) (2016) 547.[3] D.K. Thu, V.M. Hung, N.T. Trang, B.T. Tung. Study on α-glucosidase enzyme inhibitory activity and DPPH free radical scavenging of green coffee bean extract (Coffea canephora). VNU Journal of Science: Medical and Pharmaceutical Sciences 35(2) (2019).[4] C.Y. Li, H.X. Xu, Q.B. Han, T.S. Wu. Quality assessment of Radix Codonopsis by quantitative nuclear magnetic resonance. Journal of Chromatography A 1216(11) (2009) 2124.[5] S.M. Gao, J.S. Liu, M. Wang, T.T. Cao, Y.D. Qi, B.G. Zhang, et al. Traditional uses, phytochemistry, pharmacology and toxicology of Codonopsis: A review. Journal of ethnopharmacology 219((2018) 50.[6] T.T. Ha, H.V. Oanh, D.T. Ha. Chemical constituents of the n-butanol fractions from the roots of Vietnamese Codonopsis javanica (Blume) Hook.f. Journal of Pharmacy 56(4) (2016).[7] T.T. Ha, N.M. Khoi, N.T. Ha, N.V. Nghi, D.T. Ha. Chemical Constituents from Roots of Codonopsis javanica (Blume) Hook.f. Journal of Medicinal Materials 19((2014) 211.[8] B.T. Tung, D.K. Thu, N.T.K. Thu, N.T. Hai. Antioxidant and acetylcholinesterase inhibitory activities of ginger root (Zingiber officinale Roscoe) extract. Journal of Complementary and Integrative Medicine 14(4) (2017).[9] B.T. Tung, D.K. Thu, P.T. Hai, N.T. Hai. Evaluation of α-glucosidase inhibitory effects of Pomegranate fruit extracts (Punica granatum Linn). Journal of Traditional Vietnamese Medicine and Pharmacy 5(18) (2018) 59.[10] F. Moradi-Afrapoli, B. Asghari, S. Saeidnia, Y. Ajani, M. Mirjani, M. Malmir, et al. In vitro α-glucosidase inhibitory activity of phenolic constituents from aerial parts of Polygonum hyrcanicum. DARU Journal of Pharmaceutical Sciences 20(1) (2012) 37.[11] D.T. Bao. Free radicals. Journal of Pharmacy 6((2001) 29.[12] M. Carocho, I.C. Ferreira. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food and chemical toxicology 51((2013) 15.[13] National Institute of Medicinal Materials. Method for studying the pharmacological effects of herbal drugs. Science and Technology Publishing House, 2006.[14] J.W. Baynes. Role of oxidative stress in development of complications in diabetes. Diabetes 40(4) (1991) 405.[15] S.M. Jeon, S.Y. Kim, I.H. Kim, J.S. Go, H.R. Kim, J.Y. Jeong, et al. Antioxidant activities of processed Deoduck (Codonopsis lanceolata) extracts. Journal of the Korean Society of Food Science and Nutrition 42(6) (2013) 924.[16] C.S. Yoo, S.J. Kim. Methanol extract of Codonopsis pilosula inhibits inducible nitric oxide synthase and protein oxidation in lipopolysaccharide-stimulated raw cells. Tropical Journal of Pharmaceutical Research 12(5) (2013) 705.[17] J.Y.W. Chan, F.C. Lam, P.C. Leung, C.T. Che, K.P. Fung. Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 23(5) (2009) 658.[18] S. Kumar, S. Narwal, V. Kumar, O. Prakash. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacognosy reviews 5(9) (2011) 19.[19] K. Tadera, Y. Minami, K. Takamatsu, T. Matsuoka. Inhibition of α-glucosidase and α-amylase by flavonoids. Journal of nutritional science and vitaminology 52(2) (2006) 149.[20] C.W. Choi, Y.H. Choi, M.-R. Cha, D.S. Yoo, Y.S. Kim, G.H. Yon, et al. Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. Journal of agricultural and food chemistry 58(18) (2010) 9988.[21] K. He, X. Li, X. Chen, X. Ye, J. Huang, Y. Jin, et al. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. Journal of ethnopharmacology 137(3) (2011) 1135.[22] S.W. Jung, A.J. Han, H.J. Hong, M.G. Choung, K.S. Kim, S.H. Park. alpha-glucosidase inhibitors from the roots of Codonopsis lanceolata Trautv. Agricultural Chemistry and Biotechnology 49(4) (2006) 162.[23] R. Gupta, A.K. Sharma, M. Dobhal, M. Sharma, R. Gupta. Antidiabetic and antioxidant potential of β‐sitosterol in streptozotocin‐induced experimental hyperglycemia. Journal of diabetes 3(1) (2011) 29.[24] R. Khanra, N. Bhattacharjee, T.K. Dua, A. Nandy, A. Saha, J. Kalita, et al. Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats. Biomedicine & Pharmacotherapy 94((2017) 726.[25] A.I. Alagbonsi, T.M. Salman, H.M. Salahdeen, A.A. Alada. Effects of adenosine and caffeine on blood glucose levels in rats. Nigerian Journal of Experimental and Clinical Biosciences 4(2) (2016) 35.[26] A.M. Mahmoud, O.E. Hussein. Hesperidin as a promising anti-diabetic flavonoid: the underlying molecular mechanism. Int J Food Nutr Sci| Volume 3(3) (2014) 1.

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Section: Bàn Luậnunclassified

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Thuy¹,

Trang²,

Bình³

et al. 2020

MPS

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“…더덕 추출물에 대한 국내 연구는 미백효과 (Kim et al, 2002;Kim et al, 2013a;Lee et al, 2002), 항산화 효과 (Boo et al, 2018;Jeon et al, 2013;Jung & Ryu, 2018;Kim et al, 2010a;Kim et al, 2010b;Kim et al, 2010c;Park et al, 2010), 항 당뇨효과 (Kim et al, 2016), 면역효과 (Kim et al, 2014) (Kim et al, 1992;Oh et al,2006;Park et al,1989)…”

Section: A C C E P T E Dunclassified

Deodorization Effects and Antibacterial Activity of Codonopsis lanceolata Extract

Lee¹,

Ryu²

2019

Asian J Beauty Cosmetol

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Purpose: The antioxidant effects and antibacterial effects on 7 types of dermatitis of Codonopsis lanceolata (C. lanceolata) ethanol and water extracts were investigated to study its potential as an ingredient of antibacterial cosmetics for skin and functional cosmetics for hair by testing its deodorization effects on ammonia.Methods: The total polyphenol and flavonoid contents, electron donating ability, ABTS radical scavenging activity of C. lanceolata extracts were investigated for its antioxidant effects and the antibacterial effects of c. lanceolata extract on 7 different germs causing dermatitis were explored with the paper disc method. In addition, a gas detection method was employed to test the deodorizing effects on ammonia.Results: As a result of the antioxidant effects test, the total polyphenol contents of C. lanceolata ethanol and water extracts were 88.86±1.64 and 76.46±1.23 μg/mL, respectively, and the total flavonoid contents were measured 78.29±1.13 and 60.02±1.35μg/mL, respectively. As for the 2,2-diphenylpicrylhydrazyl (DPPH) scavenging activity was 78.78% and 62.12%. The test on 2,2'-Azinobis [3ethylbenzothiazoline-6-sulfonic acid]-diammonium salt (ABTS) radical scavenging activity with was 80.12% and 72.24%. For the 7 dermatitis germs, C. lanceolata ethanol extract and water extract showed antibacterial effects at the concentration of 5 mg/mL. For the deodorization effects of C. lanceolata extract on ammonia, ethanol extract revealed 98% of deodorizing effects after 30 min. Conclusion: C. lanceolata ethanol extract had greater antioxidant effects and antibacterial effects on the 7 dermatitis germs than water extract; with higher deodorizing effects, it is considered suitable for making antibacterial cosmetics for skin and functional products for hair.

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“…This valuable plant exhibits excellent pharmacological properties due to its inherent diverse secondary metabolites such as triterpenoid saponins, phenylpropanoids, alkaloids, polyacetylenes, and other compounds ( Hossen et al, 2016 ; Du et al, 2018 ). These properties include antioxidant ( Jeon et al, 2013 ), antimicrobial ( He et al, 2010 ), anti-inflammatory ( Li et al, 2007 ), and immune-modulatory ( Lee et al, 2007 ) effects, making the plant highly valuable for commercial use. Moreover, C. lanceolata is considered a substitute for Panax ginseng , commonly treated as a panacea in Korea.…”

Section: Introductionmentioning

confidence: 99%

The chromosome-level genome assembly of lance asiabell (Codonopsis lanceolata), a medicinal and vegetable plant of the Campanulaceae family

Jang

Kang

et al. 2023

Front. Genet.

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Codonopsis lanceolata (2n = 2x = 16) belongs to the Campanulaceae family and is a valuable medicinal and vegetable plant primarily found in East Asia. Several studies have demonstrated its excellent pharmacological effects, for example in bronchial treatment. However, genomic information of C. lanceolata is scarce, hindering studies on crop improvement of the species. Here, we report a high-quality chromosome-level genome assembly of C. lanceolata based on a hybrid method using Nanopore long-read, Illumina short-read, and Hi-C data. The assembled genome was completed as 1,273 Mb (84.5% of the estimated genome size), containing eight pseudo-chromosomes, ranging from 101.3 to 184.3 Mb. The genome comprised of 71.3% repeat sequences and 46,005 protein-coding genes, of which 85.7% genes were functionally annotated. Completeness of the assembled genome and genes was assessed to be 97.5% and 90.4%, respectively, by Benchmarking Universal Single-Copy Orthologs analysis. Phylogenetic and synteny analysis revealed that C. lanceolata was closely related to Platycodon grandiflorus in the Campanulaceae family. Gene family evolution revealed significant expansion of related genes involved in saponin biosynthesis in the C. lanceolata genome. This is the first reference genome reported for C. lanceolata. The genomic data produced in this study will provide essential information for further research to improve this medicinal plant and will broaden the understanding of the Campanulaceae family.

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Antioxidant Activities of Processed Deoduck (Codonopsis lanceolata) Extracts

Cited by 22 publications

References 45 publications

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Evaluation of Antioxidant and α-glucosidase Inhibitory Activities of Codonopsisjavanica (Blume) Hook. f. Thoms’ Root Extract

Deodorization Effects and Antibacterial Activity of Codonopsis lanceolata Extract

The chromosome-level genome assembly of lance asiabell (Codonopsis lanceolata), a medicinal and vegetable plant of the Campanulaceae family

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