Antioxidant activitiy of Lactobacillus plantarum , Lactobacillus sake and Lactobacillus curvatus strains isolated from fermented Turkish Sucuk

Düz, Mürüvvet; Doğan, Yağmur Nil; Doğan, İlkay

doi:10.1590/0001-3765202020200105

Cited by 31 publications

(13 citation statements)

References 42 publications

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“…It is assumed that these proteins are associated with the chelation of copper ions [86]. The chelating activity of lactobacilli and bifidobacteria is strain-specific [87]. Mechanisms of antioxidant action of lactobacilli and bifidobacteria inside the intestine of the host.AO: antioxidant; OS: oxidative stress; SCFAs: short-chain fatty acids; NF-κB: nuclear factor kappa B, eukaryotic transcription factor; SIRTs: a family of NAD-dependent protein deacetylases; PKC: protein kinase C; MAPKs: mitogen-activated protein kinases; SOD: superoxide dismutase; CAT: catalase; GSH: reduced glutathione; GSSH: oxidized glutathione; GSH-Px: glutathione peroxidase; GR: glutathione reductase; NRF2-Keap-ARE: a signaling system responsible for the expression of antioxidantresponsive elements (ARE-genes).…”

Section: Chelation Of Pro-oxidative Metal Ionsmentioning

confidence: 99%

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Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

et al. 2021

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Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties are attracting more and more attention. Multiple in vivo and in vitro studies have demonstrated that lactobacilli and bifidobacteria, along with their cellular components, possess excellent antioxidant capacity, which provides a certain degree of protection to the human body against diseases associated with oxidative stress. Recently, lactobacilli and bifidobacteria have begun to be considered as a new source of natural antioxidants. This review summarizes the current state of research on various antioxidant properties of lactobacilli and bifidobacteria. Special emphasis is given to the mechanisms of antioxidant activity of these bacteria in the human gut microbiota, which involve bacterial cell components and metabolites. This review is also dedicated to the genes involved in the antioxidant properties of lactobacilli and bifidobacteria strains as indicators of their antioxidant potential in human gut microbiota. Identification of the antioxidant biomarkers of the gut microbiota is of great importance both for creating diagnostic systems for assessing oxidative stress and for choosing strategies aimed at restoring the normal functioning of the microbiota and, through it, restoring human health. In this review, the practical application of probiotic strains with proven antioxidant properties to prevent oxidative stress is also considered.

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Section: Chelation Of Pro-oxidative Metal Ionsmentioning

confidence: 99%

“…It is assumed that these proteins are associated with the chelation of copper ions [86]. The chelating activity of lactobacilli and bifidobacteria is strain-specific [87].…”

Section: Chelation Of Pro-oxidative Metal Ionsmentioning

confidence: 99%

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

et al. 2021

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“…The strain of L. plantarum 423, L. plantarum 200655, and L. plantarum RG14 showed strong free radical–scavenging activity, and exert strong antioxidant capacity of human umbilical vein endothelial cells, human colon adenocarcinoma cell line, and post-weaning lambs, respectively ( 18 – 20 ). According to the mechanisms related to probiotic effects, L. plantarum and L. reuteri have been reported to limit excessive amounts of reactive radicals against oxidative stress in vivo ( 21 , 22 ). Another study showed that dietary supplementation of L. plantarum ZLP001 increased the activity of serum SOD and GSH-Px in weaned pigs and reduced MDA content ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Effects of L. plantarum CGMCC 1258 and L. reuteri LR1 on Growth Performance, Antioxidant Function, and Intestinal Immunity in Weaned Pigs

Tang

Wang

et al. 2021

Front. Vet. Sci.

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Lactobacillus plantarum CGMCC 1258 and Lactobacillus reuteri LR1 are two important strains of probiotics. However, their different advantages in the probiotic effect of weaned pigs are still poorly understood. Therefore, the study was to investigate the comparative effects of dietary supplementation of L. plantarum CGMCC 1258 and L. reuteri LR1 on growth performance, antioxidant function, and intestinal immunity in weaned pigs. Ninety barrows [initial body weight (BW) = 6.10 ± 0.1 kg] 21 days old were randomly divided into 3 treatments with 5 replicates, each replicate containing 6 pigs. Pigs in control (CON) were fed a basal diet, and the basal diets supplemented with 5 × 1010 CFU/kg L. plantarum CGMCC 1258 (LP) or L. reuteri LR1 (LR) for 42 days, respectively. The results showed that LP increased (p < 0.05) serum superoxide dismutase (SOD), and decreased (p < 0.05) serum malondialdehyde (MDA) and the expression and secretion of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in intestinal mucosa, but has no significant effect on growth performance and diarrheal incidence. However, LR increased (p < 0.05) final BW and average daily gain (ADG), reduced (p < 0.05) 29–42-day diarrheal incidence, decreased (p < 0.05) the expression and secretion of IL-1β, IL-6, TNF-α, and IFN-γ, and increased (p < 0.05) the expression of transforming growth factor-β (TGF-β) in intestinal mucosa. In addition, the serum glutathione peroxidase (GSH-PX), mRNA relative expression of Na+-K+-2Cl– co-transporter 1 (NKCC1) and cystic fibrosis transmembrane conductance regulator (CFTR) and the content of toll-like relative (TLR2) and TLR4 in the jejunum, and secretory immunoglobulin (sIgA) content of ileal mucosa were higher (p < 0.05) than LP. Collectively, dietary L. plantarum CGMCC 1258 improved intestinal morphology, intestinal permeability, intestinal immunity, and antioxidant function in weaned pigs. Dietary L. reuteri LR1 showed better growth performance, a lower incidence of diarrhea, better intestinal morphology, and a higher extent of immune activation in weaned pigs.

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“…Though the ndings here on FB1 toxicity were primarily con rmatory of earlier ones in the above noted studies, the present study also showed that host co-treatment with the LPBEJ01 strain appeared to mitigate many of the toxicities inducible by FB1 in the jejunum of the test mice. Based on ndings from several other studies using Lactobacillus strains, it could be that the anti-oxidative effects (Düz et al 2020;Zhou et al 2020) imparted by the microorganism were su cient to prevent the expected damage to gut cells expected to be induced by the FB1. Conversely (or even concurrently), the ability of some Lactobacillus strains to bind myco-toxins (Kankaanpää et al 2000;Jebali et al 2018) during the cotreatments could be the under-lying mechanism of protection being observed here.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Paracasei BEJ01 Protects Against Fumonisin B1-Induced Intestinal Toxicity in Balb/c Mice

Ezdini

Salah-Abbès

Belgacem

et al. 2021

Preprint

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Fumonisin B1 (FB1) is a carcinogenic (Class 2B) mycotoxin produced by Fusarium fungi and is responsible for several types of mycotoxicoses in animals and humans. Lactobacillus paracasei (LP), as a probiotic, is known to impart a wide range of advantageous effects on host health. The objective of the current study was to evaluate if LP (type BEJ01) isolated from Tunisian artisanal butter, could potentially help protect a host against intestinal alterations caused by exposure to FB1. Here, adult male Balb/c mice were randomly assigned to four groups, i.e., control (vehicle only), treated with FB1 (100 µg/kg BW), LP (2 × 109 CFU/ml [≈ 2 mg/kg BW]) and FB1 (100 µg/kg BW) + LP (2 × 109 CFU/ml) and treated per os daily for 10 days. At 24 hr after the final treatment, mice were euthanized and their jejunum harvested for examination of intestinal alterations induced by the FB1. The data showed that a variety of negative effects in jejunal tissue were induced by the FB1, including DNA fragmentation, oxidative stress, apoptotic cell death, and histopathological alterations. The results also showed that co-treatment of LP with FB1 was able to mitigate the harmful FB1 effects. LP alone imparted no damage to jejunal tissues. These results show that apart from potential use as a bio-preservative for extending the shelf-life of food and feeds, LP may also provide a benefit of helping prevent untoward effects from a potent mycotoxin like FB1.

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Antioxidant activitiy of Lactobacillus plantarum , Lactobacillus sake and Lactobacillus curvatus strains isolated from fermented Turkish Sucuk

Cited by 31 publications

References 42 publications

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Comparative Effects of L. plantarum CGMCC 1258 and L. reuteri LR1 on Growth Performance, Antioxidant Function, and Intestinal Immunity in Weaned Pigs

Lactobacillus Paracasei BEJ01 Protects Against Fumonisin B1-Induced Intestinal Toxicity in Balb/c Mice

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