Antioxidant Activity and Bioactive Compounds of Tropical Brown Algae Padina sp. from Bintan Island, Indonesia

Hidayati, Jelita Rahma; Bahry, Muhammad Syaifudien; Karlina, Ita; Yudiati, Ervia

doi:10.14710/jkt.v25i3.15562

Cited by 3 publications

(5 citation statements)

References 30 publications

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“…The use of polar solvents causes this because, generally, chlorophyll and carotenoids are semipolar compounds, so they dissolve more easily in solvents that have the same polarity. In accordance with the statement that chlorophyll and carotenoids are more easily dissolved in semi-polar solvents [8]. Pigment is an antioxidant because it contains chlorophyll, which can reduce free radicals [16].…”

Section: Pigments Contentmentioning

confidence: 57%

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Bioactive Compounds and Antioxidant Activity of Mangrove Fruit Extract Bruguiera gymnorrhiza from Pengudang Village, Indonesia

Rahma Hidayati,

Wijaya,

Hikmat Nugraha

et al. 2023

BIO Web Conf.

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In some parts of Indonesia, people have consumed mangrove fruit as a traditional food. Bruguiera gymnorrhiza or lindur plant, is one of the mangroves that have bioactive compounds as antioxidant. Antioxidant compounds found in Brugueira gymnorrizha fruit are thought to be able to reduce free radicals. However, the information on the benefits and potential of mangrove fruit as a source of antioxidants is still limited. Not many studies have shown that lindur plant fruit can be used as antioxidants, Therefore, further research on this topic is needed. This research aimed to identify the content of bioactive compounds and the activity of Brugueira gymnorrhiza fruit extract obtained from the Pengudang waters of Bintan Island. This research includes several analyses, including analysis of bioactive compound content, total phenolics and flavonoid content, pigment content, and antioxidant activity analysis. The method used in this research was a laboratory experimental and the DPPH (1,1-diphenyl-2-picrylhydrazyl) method was used to test the antioxidant activity of Bruguiera gymnorrhiza fruit extract. The results showed that the bioactive compounds contained in Bruguiera gymnorrhiza fruit extract are flavonoid and tannin compounds. The total phenolics and flavonoids amounted to 4.05 mg GAE/g sample and 9.36 mg QE/g sample. The content of chlorophyll a, chlorophyll b, and carotenoid pigments were 0.47 mg/g, 1.03 mg/g, and 2.72 μmol/g. Bruguiera gymnorrhiza extract has potent antioxidant activity (IC50 60.77 ppm).

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Section: Pigments Contentmentioning

confidence: 57%

“…Pigment is an antioxidant because it contains chlorophyll, which can reduce free radicals [16]. Apart from chlorophyll, there are carotenoids that have antioxidant capabilities as single oxygen reducers through conjugate bonds in the carbon chain [8].…”

Section: Pigments Contentmentioning

confidence: 99%

Bioactive Compounds and Antioxidant Activity of Mangrove Fruit Extract Bruguiera gymnorrhiza from Pengudang Village, Indonesia

Rahma Hidayati,

Wijaya,

Hikmat Nugraha

et al. 2023

BIO Web Conf.

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“…Three milliliters of a 0.1 mM DPPH solution were added to one milliliter of each concentration. The solution was incubated for 55 minutes [23] before the absorbance of the mixture was determined at the DPPH maximal wavelength (515.5 nm) [23].…”

Section: Antioxidant Activity Measurementmentioning

confidence: 99%

“…While the flavonoid content produced is lower when compared to brown seaweed of the Padina sp. 35.36 mg/QE g of flavonoids [23]. This difference in total phenol and flavonoid content will affect the antioxidant ability of the sample.…”

Section: Bioactive Compounds Of Gracilaria Spmentioning

confidence: 99%

Bioactive Compounds and Antioxidant Activity of Tropical Red Algae Gracilaria sp. from Bintan Island, Indonesia

Hidayati

Karlina

Ningsih

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Macroalgae that grow in the tropics are continuously exposed to ultraviolet radiation and sunlight. Macroalgae have self-defense to avoid damage caused by ultraviolet radiation by carrying out secondary metabolism and producing several bioactive compounds. The bioactive compounds produced have the potential to be utilized to inhibit free radicals that can cause degenerative diseases in humans. This research aims to identify bioactive compounds and determine the antioxidant activity, total phenolic compound, total flavonoid compound, and pigment content of red algae Gracilaria sp. from Bintan island. This research has the novelty of the sampling location to be later developed into a sustainable resource in the pharmaceutical field. Gracilaria sp. found in Bintan island was taken, dried in indirect sunlight, and macerated using universal solvent methanol. Phytochemical testing was conducted to determine the presence of flavonoids, steroids, triterpenoids, saponins, and tannins. Antioxidant activity was determined using DPPH as a free radical at the maximum wavelength of DPPH (515 nm) with an incubation time of 55 minutes. Total phenolic and flavonoid compounds were determined using standard solutions of gallic acid and quercetin, respectively. The results showed that the methanol extract of Gracilaria sp. contains flavonoid and tannin compounds, has a chlorophyll-a content of 0.43 mg/g, a carotenoid content of 0.91 µmol/g, the total phenolic compound of 4.67 mg/GAE g, total flavonoid compound of 2.26 mg/QE g and has antioxidant activity with IC50 value of 982.25 ppm. Utilization of Gracilaria sp extract from Bintan waters as a pharmaceutical ingredient is expected to increase prospects and sustainable use in the pharmaceutical and health fields.

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“…[ 8 ] However, none of the reported studies evaluate the algae effect on PMN. [ 9 10 ] Thus, the study reported herein had the objective to examine in vivo the activity of red algae on wound healing by observing the cell viability of PMN.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic extract of Gracilaria spp. Attenuates the inflammatory stage of oral mucosa wound healing: An in vivo study

Hakim,

Idroes,

Hanafiah

et al. 2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Millions of bacteria present in the mouth cavity contribute to the challenging management of oral mucosa injury. On the other hand, Gracilaria spp. (red algae) is one of the widely cultivated algae that have a strong potential as a wound-healing agent for oral mucosa injury. This study aimed to investigate the wound-healing property of the red algae by observing its effect on polymorphonuclear (PMN), a neutrophil that is usually recruited during the initial wound healing. The extract was obtained through maceration and used as bioactive ingredient in gel preparation. Rattus norvegicus with incision wounds in the oral mucosa was used as the animal model. Our results revealed that rats treated with the red algae gel had significantly lower PMN on the injury site (P < 0.01) as observed on days 1, 3, and 5. Identification using gas chromatography–mass spectrometry showed that the extract was rich in hexadecenoic acid and glycerol. The brine shrimp lethality test suggested low cytotoxicity of this extract with LC50 = 10694.93 mg/mL. In conclusion, the extract could be potentially used as bioactive ingredient in gel formulation for topical management of oral mucosa wounds. Further, research to confirm these findings is warranted.

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Antioxidant Activity and Bioactive Compounds of Tropical Brown Algae Padina sp. from Bintan Island, Indonesia

Cited by 3 publications

References 30 publications

Bioactive Compounds and Antioxidant Activity of Mangrove Fruit Extract Bruguiera gymnorrhiza from Pengudang Village, Indonesia

Bioactive Compounds and Antioxidant Activity of Mangrove Fruit Extract Bruguiera gymnorrhiza from Pengudang Village, Indonesia

Bioactive Compounds and Antioxidant Activity of Tropical Red Algae Gracilaria sp. from Bintan Island, Indonesia

Ethanolic extract of Gracilaria spp. Attenuates the inflammatory stage of oral mucosa wound healing: An in vivo study

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