Antioxidant activity and molecular docking study of Erythrina × neillii polyphenolics

Gabr, Salma K.; Bakr, Riham O.; Mostafa, Eman S.; El-Fishawy, Ahlam M.; El-Alfy, Taha S.

doi:10.1016/j.sajb.2018.12.011

Cited by 16 publications

(15 citation statements)

References 37 publications

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“…Isovitexin and vitexin have also demonstrated ferric reducing capacities [ 128 , 133 , 151 , 169 ] and Fe II chelating abilities [ 160 , 161 ]. Vitexin 2″-O- β -D-xylosyl vitexin and 2″-O-galloyl vitexin exhibited the strongest antioxidant activity in ORAC assay [ 170 , 171 ].…”

Section: Resultsmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.

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Section: Resultsmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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“…In vitro radical scavenging assay (DPPH) was the most widely used in vivo test to determine the capacity of free radical scavenging ( Table 3 ). In most studies, a similar and even higher activity was obtained than the positive controls (Trolox, BHA, ascorbic acid and quercetin) [ 58 , 65 , 66 , 67 , 68 ]. Reduction of Fe ions was also evaluated, an assay often used as an indicator of electron donation activity (FRAP).…”

Section: Radical Scavenging Activity In the Model In Vitro Systemsmentioning

confidence: 82%

“…Docking studies shows that phaseollin of Erythrina variegata has the best fitness score against the COX-1 which is 56.64 and 59.63 for COX-2 enzyme [ 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. However, is required to delve into the possible mechanisms of action, as well as the phytoconstituents and their relationship with the biological activity [ 58 ].…”

Section: Preclinical Studies Of Pain and Inflammation From The Genmentioning

confidence: 99%

“…Additionally. Additionally, flexible molecular docking on heme oxygenase (HO-1), an important stress protein that is involved in cellular protection, antioxidant and anti-inflammatory activities, justified the antioxidant activity of the isolated compounds [ 58 ]. One of the pathways implicated in the control of inflammation Nrf2 that controls the expression of antioxidant response element-regulated antioxidant and cyto-protective genes, such as NAD(P)H: quinone oxidoreductase 1 (NQO1), γ-glutamyl cysteine synthetase catalytic subunit (GCLC), and heme oxygenase (HO)-1 [ 113 ].…”

Section: Molecular Mechanisms Of Anti-inflammatory Activity Of Thementioning

confidence: 99%

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Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?

Cabrera

Bautista

Velázquez

et al. 2020

IJMS

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The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature’s medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant.

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“…Reactive oxygen species (ROS) generated during oxidation and rancidity of fats and oils are the main reason for oxidative damage, which causes cell or oxidative stress associated with many chronic diseases, like diabetes, cancer, and cardiovascular disorders. Therefore, antioxidants are used extensively to maintain the balance of redox homeostasis and reduced levels of oxidative stress [ 9 ]. Nowadays, molecular docking has been applied as a mechanistic tool to study the inhibition of enzymes that negatively affect antioxidant activity, like NADPH oxidase (NO), which is responsible for ROS generation [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and Molecular Docking Study of Volatile Constituents from Different Aromatic Lamiaceous Plants Cultivated in Madinah Monawara, Saudi Arabia

Farouk¹,

Mohsen²,

Ali

et al. 2021

Molecules

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A comparative study of volatile constituents, antioxidant activity, and molecular docking was conducted between essential oils from Mentha longifolia L., Mentha spicata L., and Origanum majorana L., widely cultivated in Madinah. The investigation of volatile oils extracted by hydrodistillation was performed using Gas Chromatography-Mass Spectrometry (GC-MS). A total number of 29, 42, and 29 components were identified in M. longifolia, M. spicata, and O. majorana representing, respectively, 95.91, 94.62, and 98.42, of the total oils. Pulegone (38.42%), 1,8-cineole (15.60%), menthone (13.20%), and isopulegone (9.81%) were the dominant compounds in M. longifolia oil; carvone (35.14%), limonene (27.11%), germacrene D (4.73%), and β-caryophyllene (3.02%) were dominant in M. spicata oil; terpin-4-ol (42.47%), trans-sabinene hydrate (8.52%), γ-terpinene (7.90%), α-terpineol (7.38%), linalool (6.35%), α-terpinene (5.42%), and cis-sabinene hydrate (3.14%) were dominant in O. majorana oil. The antioxidant activity, assessed using DPPH free radical–scavenging and ABTS assays, was found to be the highest in O. majorana volatile oil, followed by M. spicata and M. longifolia, which is consistent with the differences in total phenolic content and volatile constituents identified in investigated oils. In the same context, molecular docking of the main identified volatiles on NADPH oxidase showed a higher binding affinity for cis-verbenyl acetate, followed by β-elemene and linalool, compared to the control (dextromethorphan). These results prove significant antioxidant abilities of the investigated oils, which may be considered for further analyses concerning the control of oxidative stress, as well as for their use as possible antioxidant agents in the pharmaceutical industry.

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Antioxidant activity and molecular docking study of Erythrina × neillii polyphenolics

Cited by 16 publications

References 37 publications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?

Antioxidant Activity and Molecular Docking Study of Volatile Constituents from Different Aromatic Lamiaceous Plants Cultivated in Madinah Monawara, Saudi Arabia

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Antioxidant activity and molecular docking study of Erythrina × neillii polyphenolics

Cited by 16 publications

References 37 publications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?

Antioxidant Activity and Molecular Docking Study of Volatile Constituents from Different Aromatic Lamiaceous Plants Cultivated in Madinah Monawara, Saudi Arabia

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Antioxidant activity and molecular docking study of Erythrina × neillii polyphenolics