Antioxidant Activity and Phenolic Content of Streblus asper Leaves from Various Drying Methods

Ibrahim, Nor Mawarti; Mat, Ishak; Lim, Vuanghao; Ahmad, Rosma

doi:10.3390/antiox2030156

Cited by 27 publications

(24 citation statements)

References 33 publications

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“…niruri (62.6 – 68.7 mg GAE/g dried sample), and S . asper leaves (296 – 303 mg GAE/g dried sample) . Proanthocyanidin content of PTL determined in this study was much higher than those of P .…”

Section: Resultsmentioning

confidence: 53%

Physicochemical Properties, Antioxidant and Anti‐proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera)

Nguyen

Sakoff

Scarlett

2017

Chemistry & Biodiversity

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Xao tam phan (Paramignya trimera) has been used for the treatment of cancer and cancer-like aliments. Among different parts of the P. trimera plant, leaf is considered as a residual part after harvesting of the root. This study aimed to determine the physiochemical properties and the antioxidant and anti-proliferative capacities of P. trimera leaf (PTL) using microwave drying for the preparation of dry sample; MeOH and microwave-assisted extraction for the preparation of crude extract; and freeze-drying for the preparation of powdered extract. The results showed that total phenolic, total flavonoid, proanthocyanidin, and saponin contents of PTL prepared by microwave drying at 450 W were 25.4 mg gallic acid equiv. (GAE), 86.3 mg rutin equiv. (RE), 5.6 mg catechin equiv. (CE), and 702.1 mg escin equiv. (EE) per gram dried sample, respectively. Gallic acid, protocatechuic acid, ellagic acid, rutin, and quercetin were identified in the PTL MeOH extract. Dried PTL displayed potent antioxidant activity, while the powdered PTL extract exhibited great anti-proliferative capacity on various cancer cell lines including MiaPaCa-2 (pancreas), HT29 (colon), A2780 (ovarian), H460 (lung), A431 (skin), Du145 (prostate), BE2-C (neuroblastoma), MCF-7 (breast), MCF-10A (normal breast), and U87, SJ-G2, and SMA (glioblastoma). Anti-proliferative capacity on pancreatic cancer cells (MiaCaPa2, BxPc3, and CFPAC1) of PTL extract (200 μg/ml) was significantly higher (P < 0.05) than those of ostruthin (20 μg/ml) and gemcitabine (50 nm), and to be comparable to the powdered P. trimera root extract and a saponin-enriched extract from quillajia bark (a commercial product). The findings from this study allow us to conclude that the PTL is a rich source of phytochemicals that possess promising antioxidant and anti-proliferative activities, therefore it shows potential as lead compounds for application in the nutraceutical, medicinal and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 53%

Physicochemical Properties, Antioxidant and Anti‐proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera)

Nguyen

Sakoff

Scarlett

2017

Chemistry & Biodiversity

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“…[31] The freeze drying of Mentha viridis possessed the highest TPC (35 mg GAE/g dried sample), followed by air drying with and without sun exposure, microwave, and conventional drying (20, 16, 12 and 11 mg GAE/g dried sample, respectively). [26] In comparison with other plants, the TPC of the P. trimera root was much higher than that of sage plants, [31] (approximately 2.3 mg GAE/g dried sample) but lower than that of Oolong tea, [24] (13.58 mg GAE/g dried sample) and papaya leaf [28] (15.03 mg GAE/g dried sample), and significantly lower than those of P. amarus, [9] P. urinaria and P. niruri [32] (50.24, 62.56 and 68.70 mg GAE/g dried sample, respectively), and of S. asper leaves obtained by freeze and oven drying [33] (303 and 296 mg GAE/g dried sample, respectively). These results showed that for the TPC retention of the P. trimera root, there were no significant differences across all drying methods, and microwave drying was the most effective method in retaining TPC of the P. trimera root, with least energy consumption.…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

Phytochemical retention and antioxidant capacity of xao tam phan (Paramignya trimera) root as prepared by different drying methods

et al. 2015

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Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as a herbal medicine for the treatment of cancer or cancer-like diseases in recent years, particularly in Vietnam. Drying is an important step for preparation of dried materials for storage and further investigation; however, the effects of drying must be taken into account when processing samples, as this can have profound effects on the stability of phytochemical compounds and the biological activity of the dried P. trimera root. As such, this study assessed the effects of four different drying methods (conventional, hot-air, vacuum, and microwave) on phytochemical retention and antioxidant capacity of the P. trimera root, to identify an optimal drying method for the P. trimera root. The results showed that the drying methods significantly affected phytochemical levels and antioxidant capacity of the P. trimera root, and that among the four drying methods tested, microwave drying (400 W) had the highest levels of phytochemical compounds with total phenolic, total flavonoid, Downloaded by [New York University] at 13:46 31 July 2015 2 proanthocyanidin, and saponin contents being 11.27 mg GAE, 19.88 mg RE, 3.98 mg CE, and 267.15 mg EE/gram of dried sample, respectively. Dried sample prepared using this method had comparable antioxidant capacity with other drying methods. In addition, this method had the shortest drying time (0.28 h), and consumed the least energy (0.28 kWh).Therefore, microwave drying method should be considered for drying P. trimera root for further investigation and utilization.

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“…The DPPH, FRAP, ABTS and phosphomolybdenum activities of the fruit samples were evaluated by the methods reported by [44,50,51], respectively. The ABTS, DPPH and phosphomolybdenum assays were reported as gallic acid equivalents (GAE µmol/gDW), whereas FRAP as Fe 2+ equivalents (Fe 2+ µmol/gDW).…”

Section: Determination Of In Vitro Antioxidant Activitymentioning

confidence: 99%

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

et al. 2020

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Selected Australian native fruits such as Davidson's plum, finger lime and native pepperberry have been reported to demonstrate potent antioxidant activity. However, comprehensive metabolite profiling of these fruits is limited, therefore the compounds responsible are unknown, and further, the compounds of nutritional value in these native fruits are yet to be described. In this study, untargeted and targeted metabolomics were conducted using the three fruits, together with assays to determine their antioxidant activities. The results demonstrate that targeted free and hydrolysed protein amino acids exhibited high amounts of essential amino acids. Similarly, important minerals like potassium were detected in the fruit samples. In antioxidant activity, Davidson's plum reported the highest activity in ferric reducing power (FRAP), finger lime in antioxidant capacity (ABTS), and native pepperberry in free radical scavenging (DPPH) and phosphomolybdenum assay. The compounds responsible for the antioxidant activity were tentatively identified using untargeted GC×GC-TOFMS and UHPLC-QqQ-TOF-MS/MS metabolomics. A clear discrimination into three clusters of fruits was observed using principal component analysis (PCA) and partial least squares (PLS) analysis. The correlation study identified a number of compounds that provide the antioxidant activities. GC×GC-TOFMS detected potent aroma compounds of limonene, furfural, and 1-R-α-pinene. Based on the untargeted and targeted metabolomics, and antioxidant assays, the nutritional potential of these Australian bush fruits is considerable and supports these indigenous fruits in the nutraceutical industry as well as functional ingredients for the food industry, with such outcomes benefiting Indigenous Australian communities.

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Antioxidant Activity and Phenolic Content of Streblus asper Leaves from Various Drying Methods

Cited by 27 publications

References 33 publications

Physicochemical Properties, Antioxidant and Anti‐proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera)

Physicochemical Properties, Antioxidant and Anti‐proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera)

Phytochemical retention and antioxidant capacity of xao tam phan (Paramignya trimera) root as prepared by different drying methods

Untargeted and Targeted Metabolomic Profiling of Australian Indigenous Fruits

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