Antioxidant activity and stability of 6‐hydroxy‐2,5,7,8‐tetramethylchroman‐2‐carboxylic acid

Cort, Winifred M.; Scott, John W.; Araújo, Maysa Lorrane Medeiros de; Mergens, William J.; Cannalonga, M. A.; Osadca, M; Harley, H.; Parrish, David J.; Pool, William R.

doi:10.1007/bf02672164

Cited by 82 publications

(21 citation statements)

References 12 publications

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“…Yet, in active oxigen method, antioxidant index for TBHQ was 3-fold higher than for BHA and BHT. Higher antioxidative activity of TBHQ compared with BHA and BHT in model studies with soybean oil and chicken fat in emulsion versus dry oil tests was reported by Cort et al (6). Relative effectiveness of antioxidants-linoleic acid monolayer on silica gel for TBHQ was almost the same as for BHT, while for BHA almost 3-fold higher (9).…”

Section: Resultsmentioning

confidence: 57%

Antioxidant activity of BHA, BHT and TBHQ examined with Miller's test

Karamać¹,

Amarowicz²

1997

Grasas y Aceites

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RESUMENActividad antioxidante de BHA, BHT y TBHQ examinada con el test de l\/liller. KEY-WORDS: Antioxidant activity -Butylated ¡lydroxyaniso-le (BHA) -Butylated hydroxytoluene (BHT) -Tertiary butyl hydroquinone (TBHQ) -Miller's test.En experimentos modelos usando el test de Miller, a 5ml de emulsión se añadió 25, 12.5, 6.25 y S.ISpg de BHA, BHT y TBHQ. Las relaciones inhibitorias (IR) para el BHA y BHT fueron similares. IR para TBHQ fue más baja que para BHA y BHT con niveles de adición del 6.25 y 3.13. Esto sugiere que en estudios modelos usando el test de Miller 25^9 de BHA, BHT, o TBHQ deben ser añadidos a 5 mi de muestra control. PALABRAS-CLAVE: Actividad antioxidante -Butil hidroquinona terciaria (TBHQ) -Butil hidroxianisol (BHA) - Butilhidroxitolueno (BHT) -Test de Miller. SUMÍVIARYAntioxidant activity of BHA, BHT and TBHQ examined witli l\/liíler's test.In model experiments with the use of Miller's test to 5 ml emulsion 25, 12.5, 6.25 and 3.13 |jg BHA, BHT and TBHQ was added. Inhibitory ratios (IR) for BHA and BHT were similar. At addition level of 6.25 and 3.13 IR for TBHQ was lower than for BHA and BHT. It is suggested that in the model studies with the use of Miller's test 25 jjg BHA, BHT or TBHQ should be added to 5 ml of control sample.

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Section: Resultsmentioning

confidence: 57%

Antioxidant activity of BHA, BHT and TBHQ examined with Miller's test

Karamać¹,

Amarowicz²

1997

Grasas y Aceites

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“…In contrast, 6-hydroxy-5,7, 8-trimethylchroman-2-carboxylic acid (Trolox C), an analog of a-tocopherol lacking the 2-trimethyldecyl side chain, was effective only at 20 pM, a 400-fold higher concentration. This compound does not show vitamin E activity (Kasparek, 1980) but is more potent than a-tocopherol in prevention of autoxidation of oils (Cort et al, 1975). Tocopherols are good antioxidants, however, and various antioxidants exhibit vitamin E activity in some systems (Schwarz, 1958a).…”

Section: Resultsmentioning

confidence: 98%

“…Although antioxidants substituted completely for a-tocopherol in the present cell culture system, the tocopherols were more potent than would be predicted from their activity in preventing autoxidation in chemical systems (Cort et al, 1975). Because tocopherols intercalate into cellular membranes (Packer, 1976), it is possible that they are more potent than simple antioxidants in certain biological systems by partitioning and exerting a selective antioxidant effect.…”

Section: *000mentioning

confidence: 93%

The role of vitamin E in cellular energy metabolism in cultured adrenocortical cells

Hornsby

1982

Journal Cellular Physiology

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ACT cells, a bovine adrenocortical cell clone, are rapidly arrested and killed by 2 mM aminooxyacetate, an inhibitor of transamination reactions. Toxicity of aminooxyacetate to cultured bovine adrenocortical cells was previously linked to a high ratio of capacity for oxidation of glutamine relative to pyruvate and was reversible by adding excess glutamine. The toxic effects of aminooxyacetate were shown in the present study to be completely prevented by the simultaneous addition of low concentrations ( < 100 nM) of d-a-tocopherol (vitamin E) or selenious acid or higher concentration of other tocopherols, antioxidants, and ubiquinones (coenzymes Q6 and Q,J. When antioxidant analogs were tested, it was found that structural features of the molecules that increase antioxidant potency increased potency for prevention of aminooxyacetate toxicity. a-Tocopherol-supplemented AC 1 cells were found to be significantly less sensitive than nonsupplemented cells to growth inhibition by rotenone but not by fluorocitrate or dinitrophenol. Dinitrophenol (100 pM) stimulated substrate oxidation fivefold but had relatively slight effects on growth, either with or without a-tocopherol, indicating that limitation of the maximal activity of the tricarboxyiic acid cycle and respiratory chain is probably not responsible for the sensitivity to aminooxyacetate and rotenone in cells not supplemented with a-tocopherol. Sensitivity to growth inhibition by rotenone and the prevention by ubiquinones of aminooxyacetate toxicity suggest a restriction of electron flow at the NADH-ubiquinone step. The resultant higher NADHINAD' ratio would result in a lowered capacity for metabolism of pyruvate with consequent dependence for tricarboxylic acid cycle function and energy production on 2-oxoglutarate from glutamine by the transamination pathway. Vitamin E and other antioxidants may restore efficient function of ubiquinone by preventing side reactions involving lipid peroxidation. Selenium may have a similar effect as cofactor for glutathione peroxidase. A high ratio of capacity for oxidation of glutamine relative to pyruvate and accompanying sensitivity to aminooxyacetate may reflect a deficiency of vitamin E and selenium in adrenocortical cells in culture.

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“…Esta substância apresenta propriedades antioxidante maiores que a das (Vitamina E) α e γ-tocoferol, tanto em gordura animal quanto vegetal (CORT et al, 1975). …”

Section: Trolox®unclassified

Artificial insemination in goats: Biotechnology association of dilution and cooling of semen

Sakashita¹,

Rodrigues²,

Rodello³

et al. 2016

Pubvet

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ResumoDas diversas biotecnologias disponíveis para a intensificação do manejo reprodutivo, preconiza-se a programação reprodutiva e distribuição dos cios e partos ao longo do ano, alicerçadas pelo uso racional da Inseminação Artificial.Essa biotécnica, com sêmen refrigerado em caprinos, apresenta resultados práticos mais viáveis, tanto do ponto de vista econômico quanto produtivo, com índices reprodutivos mais próximos daquele obtido em monta natural ou sêmen fresco, e superiores daqueles obtidos com sêmen congelado. É característico do sêmen caprino a síntese e secreção de enzimas pelas glândulas bulbo uretrais, liberadas no plasma seminal. Em função dos efeitos deletérios, a composição enzimática do sêmen do bode e os diluidores assumem grande importância no processo de conservação do sêmen congelado ou refrigerado. Aliada a outras biotécnicas reprodutivas, a inseminação

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Antioxidant activity and stability of 6‐hydroxy‐2,5,7,8‐tetramethylchroman‐2‐carboxylic acid

Cited by 82 publications

References 12 publications

Antioxidant activity of BHA, BHT and TBHQ examined with Miller's test

Antioxidant activity of BHA, BHT and TBHQ examined with Miller's test

The role of vitamin E in cellular energy metabolism in cultured adrenocortical cells

Artificial insemination in goats: Biotechnology association of dilution and cooling of semen

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