Antioxidant activity assay of Agarwood leaf extract cream (Aquilaria malaccensis L.) using free radical scavenging method

Abstract

Background: Agarwood leaves (A. malaccensis L.) are the part of the plant that is rich in antioxidants and contain phytochemicals, namely: alkaloids, flavonoids, terpenoids, steroids, and saponins. Objective: This research aimed to determine the antioxidant activity of cream-containing Agarwood leaf extract using the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical. Method: The sample was extracted by 70% ethanol and formulated at concentrations of 1% weight/volume (w/v), 3% w/v, and 5% w/v. Physical characteristics and antioxidant activity were evaluated. Results: The results showed that the agarwood leaf extract cream in all concentrations fulfilled all the requirements related to physical characteristics of good topical preparations, including organoleptic, homogeneity, pH, spreadability, and adhesion. The IC50 values of the agarwood leaf extract cream at the concentrations of 1% w/v, 3% w/v, and 5% w/v were 68.371, 62.602, and 57.756 ppm, respectively. Conclusion: This research concluded that agarwood leaf extract cream has high antioxidant or free radical scavenging properties (50 ppm-100 ppm).

Isolation and morphological identification of endophytic fungi from leaves and stems of Aquilaria malaccensis Lamk. originating from Java Island, Indonesia

“…Aquilaria malaccensis is a potential pharmacological plant due to its capacity to generate various secondary metabolites. Aquilaria malaccensis leaves extract has antioxidant (Hendra et al, 2016;Halim et al, 2022), antiviral against dengue virus (Masita et al, 2020) and immunomodulatory potential (Batubara et al, 2021;Wahid et al, 2022;Yana et al, 2022). Furthermore, the stem has been referenced for anticancer activities (Hegde et al, 2018).…”