Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae: In Vitro and In Silico Studies

Abstract

A new xanthone derivative, aspidxanthone A (1), and three known compounds ((2S)‐1‐(β‐D‐galactopyranosyloxy)‐3‐(hexadecanoyloxy)propan‐2‐yl (9Z,12Z)‐octadeca‐9,12‐dienoate (2), (25S)‐spirostane‐1β,3α,5β‐triol (3), and asparenyldiol (4)) were isolated from the whole of the endemic species Aspidistra letreae in Vietnam. Their structures were elucidated by means of extensive spectroscopic analyses and comparison with published data. In this study, we report the isolation and structure elucidation of a new compound aspidxanthone A, antioxidant activities of the extract and isolates 1–4, and in silico molecular docking of aspidxanthone A. The ethyl acetate extract had good antioxidant activity with an IC50 value of 26.3 μg mL−1. Among the isolates, aspidxanthone A exhibited DPPH reduction activity with an IC50 value of 11.2 μM, which is in the same range as that of the positive control, ascorbic acid. The mechanism of action of aspidxanthone A on the tyrosinase and xanthine oxidase proteins have been clarified by in silico studies.

Phytochemical Analysis, Antioxidant and Bone Anabolic Effects of Blainvillea acmella (L.) Philipson

“…L-ascorbic acid was chosen as a positive control. L-ascorbic acid is one of the synthesis antioxidants and has been widely used by researchers to study the antioxidant activity in plant extracts ( Manssouri et al, 2020 ; Ho et al, 2021 ). A low IC 50 value indicates the better antioxidant activity of the extracts as a potential antioxidant agent.…”

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“…Antioxidant activity was assessed using the standard DPPH⋅ assay, according to the method described by Masuda et al . with slight modifications [42,43] . 1.0 mg of the extracts and isolated compounds were completely dissolved into 100 μL of MeOH.…”

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