Antioxidant Activity of Catechins Isolate of Uncaria Gambier Roxb in Male Rats

Musdja, Muhammad Yanis; H, Rahman; Hasan, Delina

doi:10.20319/lijhls.2018.42.3446

Cited by 18 publications

(7 citation statements)

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“…In addition, catechin is reported to act as an inhibitor of angiotensin-converting enzyme activity which plays a key role in regulating arterial blood pressure [26], [27]. The purified gambir contains catechin, which has antioxidant activity [8]. Therefore, when used in sufficient doses, it will benefit the cardiovascular system [16].…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

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Khairunnisa

Rosyari

et al. 2022

Open Access Maced J Med Sci

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Introduction: Purified gambier (Uncaria gambir Roxb.) is potential for treating hypertension based on its antioxidant bioactivity. In this study, we investigated the antihypertensive performances of purified gambier on hypertensive rats and the correlation with its antioxidant activity. Methods: Rats (2-3 months old and the bodyweight of 200-250 g) were divided into five groups. Groups 1, 2, and 3 were treated orally with water suspension of purified gambier at doses of 2.5; 5; and 10 mg/kg BW once a day for 14 days, group 4 and 5 were acted as positive control (treated with vehicle) and captopril treated group (comparison) respectively. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), blood flow (BF) and blood volume (BV) were recorded once a day before and 1,3,7 and 14 days after commencement. The blood was taken before and at the end of recording for the plasma NO measurement. Two-way ANOVA was used to analyze the changes of those parameters, except for plasma NO analyzes by one-way ANOVA, followed by Duncan multirange test (95% confidence interval). Results: The study showed that significant antihypertensive effects (p<0.05), influenced by doses and gambier administration duration. The plasma NO of animals was increased after administration of purified gambier (p<0.05), although there was no significant difference in plasma NO in doses variation. Conclusion: These indicated that purified gambier proceed antioxidant associated antihypertensive effects at doses of 2.5 – 10 mg/kg BW when administered for 14 days on the salt-prednisone induced hypertensive rats. KEYWORDS: antioxidant, antihypertensive, purified gambier, Uncaria gambir Roxb., salt-prednisone induced, hypertension rat

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Section: Discussionmentioning

confidence: 99%

“…Gambir is potential as antibacterial [7], antioxidants [8], antihypertension [9], antihyperglycemic [10], hepatoprotection [11], [12], and atherosclerosis [13]. Gambir contains catechins, tannic catechu acid, quercetin, red catechin, flavonoid and fluorescent gambir [14].…”

Section: Medicinal Plants Have Long Been Knownmentioning

confidence: 99%

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Permatasari

Khairunnisa

Rosyari

et al. 2022

Open Access Maced J Med Sci

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“…Increased production of free radicals causes the growing system to require antioxidants from the outside. Antioxidants outside the body can be obtained from synthesis and naturally [ 63 ]. Synthetic antioxidants are limited in their use because they cause side effects, so natural antioxidants are needed.…”

Section: Uncaria Gambir Roxb Usesmentioning

confidence: 99%

Current Research of Phytochemical, Medicinal and Non-Medicinal Uses of Uncaria gambir Roxb.: A Review

et al. 2022

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Uncaria gambir Roxb. is a plant from Southeast Asia and is widely used as an alternative medicine with various applications. This plant has been widely used in traditional medicine. This paper aims to provide information on U. gambir, a summary of data on phytochemicals and on medical and nonmedical activities. Phytochemical studies reveal biologically active constituents such as flavonoids, phenolics, and alkaloids. Various studies have shown that extracts and compounds obtained from U. gambir have medical uses for their antioxidant, antibacterial, anti-helminthic, anticancer, antifungal, anti-inflammatory, anti-hyperglycemic, anti-hyperuricemic, anti-lipid peroxidation, antihyperlipidemic and other properties. In addition, this extract has other uses, such as adsorbent for dyes and metal ions, as well as corrosion inhibition. Thus, U. gambir, which is commonly used in traditional medicine, is a potential plant for many therapeutic applications and prospects for drug development as well as other applications such as adsorbent and corrosion inhibition.

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“…16 Table 1 shows the phytochemical content of the active compounds identified from the gambir plant. 8,17…”

Section: A Phytochemical Compoundmentioning

confidence: 99%

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

Yunarto

Sulistyaningrum

Kurniatri

et al. 2021

mpk

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Gambir (Uncaria gambir Roxb.) is a member of family of Rubiaceae. In Asia including Indonesia, extracts of gambir are empirically used daily to weed out. The high content of catechin flavonoids in gambir has a pharmacological effect in the treatment of hyperlipidemia that potential to be developed into traditional medicine. This literature review aimed to examine the potency of pharmacological effect of gambir as hyperlipidemia treatment therapy based on the results of studies in silico, in vitro, in vivo pharmacological effects and its safety to provide evidence of scientific information to the community. The literatures used for analysis in this study including evidence-based articles on both pharmacology and safety which are available in Pubmed and Google Scholar. The results showed a very strong potency of gambir plants in the treatment of hyperlipidemia with catechin as bioactive compounds. In silico study revealed mechanism action of catechin as antihyperlipidemic using 2 pathways, inhibition of the enzyme HMG-CoA reductase and increase the LDL receptors. In vitro studies of catechin are able to inhibit lipid absorption in the intestine through inhibition of pancreatic lipase activity, lipid hydrolysis and emulsification, micelle cholesterol deposition. Pre-clinical tests on animals showed that the ethyl acetate fraction of gambir leaves was able to reduce the levels of total cholesterol, triglycerides, LDL and increase blood plasma HDL. The long-term use of gambir leaves has been proven to be safe, not mutagenic, no hematological, clinical biochemical abnormalities and no abnormalities in the vital organs of the animal models. Abstrak Gambir (Uncaria gambir Roxb) adalah tumbuhan perdu dari suku Rubiaceae. Di Asia termasuk Indonesia, secara empiris ekstrak gambir digunakan sehari-hari untuk menyirih. Kandungan flavonoid katekin yang tinggi dalam gambir memiliki efek farmakologi dalam pengobatan hiperlipidemia yang berpotensi untuk dikembangkan menjadi obat tradisional. Kajian literatur ini bertujuan untuk mengkaji potensi farmakologi gambir sebagai terapi pengobatan hiperlipidemia berdasarkan hasil studi efek farmakologi in silico, in vitro, in vivo efek farmakologi dan keamanannya, sehingga memberikan bukti informasi ilmiah kepada masyakarat. Literatur yang digunakan dalam proses review meliputi literatur dengan berbasis bukti baik farmakologi maupun keamanan yang tersedia di Pubmed dan Google Scholar. Hasil kajian menunjukkan potensi yang sangat kuat dari tanaman gambir dalam pengobatan hiperlipidemia dengan katekin sebagai senyawa bioaktif utama. Studi in silico menunjukkan mekanisme aksi katekinsebagai antihiperlipidemia menggunakan dua jalur yaitu penghambatan enzim HMG-CoA reduktase dan peningkatan reseptor LDL. Studi in vitro katekin mampu menghambat penyerapan lipid di usus melalui penghambatan aktivitas lipase pankreas, hidrolisis lipid dan emulsifikasi, serta pengendapan kolesterol misel. Studi in vivo menunjukkan fraksi etil asetat daun gambir mampu menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan HDL plasma darah. Penggunaan daun gambir dalam jangka panjang terbukti aman, tidak mutagen, tidak ditemukan kelainan hematologi, biokimia klinis dan tidak menyebabkan kelainan organ vital hewan uji.

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Antioxidant Activity of Catechins Isolate of Uncaria Gambier Roxb in Male Rats

Cited by 18 publications

References 0 publications

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Antioxidant Associated Antihypertensive Performance of Purified Gambir (Uncaria gambir Roxb.) on Prednisone Salt-Induced Hypertensive Rats

Current Research of Phytochemical, Medicinal and Non-Medicinal Uses of Uncaria gambir Roxb.: A Review

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

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