Antioxidant activity of curcuminoids

Llano, Sandra; Gómez, Sara; Londoño, Jorge Eliécer Ossa; Restrepo, Albeiro

doi:10.1039/c8cp06708b

Cited by 60 publications

(45 citation statements)

References 38 publications

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“…Curcumin [1,7-bis (4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] is an organic compound from the rhizome of the Indian spice turmeric (Curcuma longa), which is one of the principal ingredients in curry powder [4]. Its wide spectrum of biological activities including antiviral [5], antioxidant [6], neuroprotective [7], antidepressant [8], and anti-inflammatory effects [9]. In addition, curcumin has shown an anti-nociceptive effect in different types of pain, such as inflammatory pain [4,7,10], visceral pain [11], musculoskeletal pain [12], burning pain [13], and neuropathic pain [14][15][16][17].…”

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confidence: 99%

Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K+ channels pathway

Pastrana-Quintos

Salgado-Moreno

Pérez‐Ramos

et al. 2020

BMC Complement Med Ther

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Background: Recent studies pointed up that curcumin produces an anti-nociceptive effect in inflammatory and neuropathic pain. However, the possible mechanisms of action that underline the anti-allodynic effect induced by curcumin are not yet established. The purpose of this study was to determine the possible anti-allodynic effect of curcumin in rats with L5-L6 spinal nerve ligation (SNL). Furthermore, we study the possible participation of the NOcyclic GMP-ATP-sensitive K + channels pathway in the anti-allodynic effect induced by curcumin. Methods: Tactile allodynia was measured using von Frey filaments by the up-down method in female Wistar rats subjected to SNL model of neuropathic pain. Results: Intrathecal and oral administration of curcumin prevented, in a dose-dependent fashion, SNL-induced tactile allodynia. The anti-allodynic effect induced by curcumin was prevented by the intrathecal administration of L-NAME (100 μg/rat, a non-selective nitric oxide synthase inhibitor), ODQ (10 μg/rat, an inhibitor of guanylatecyclase), and glibenclamide (50 μg/rat, channel blocker of ATP-sensitive K + channels). Conclusions: These data suggest that the anti-allodynic effect induced by curcumin is mediated, at least in part, by the NO-cyclic GMP-ATP-sensitive K + channels pathway in the SNL model of neuropathic pain in rats.

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confidence: 99%

Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K+ channels pathway

Pastrana-Quintos

Salgado-Moreno

Pérez‐Ramos

et al. 2020

BMC Complement Med Ther

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“…Turmeric or natural curcumoids have been reported to have antioxidant [48], anti-inflammatory [49], and antimicrobial activities [50]. CURC has recently shown anti-tumor properties, relying on the inhibition of oncogenic/pro-survival STAT-3 and NF-kB-dependent pathways, of the pro-invasive factor Sp-1, of tumor-associated inflammation [51,52].…”

Section: Discussionmentioning

confidence: 99%

“…To further investigate the mechanisms at the basis of the down-regulation of the doxorubicininduced Pgp transcription, we focused on three interconnected events elicited by doxorubicin in cancer cells and involved in Pgp up-regulation: The increase in intracellular ROS, and the activation of the transcription factors HIF-1α and NF-kB. Notably, HIF-1α and NF-kB are both Pgp inducers [33,37,38,55] and are activated in response to the increased intracellular ROS [56,57], while CURC is known to prevent oxidative stress [48]. Our data indicated that doxorubicin increased ROS levels, and HIF-1α and NF-kB activity, as expected.…”

Section: Discussionmentioning

confidence: 99%

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells

et al. 2020

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Multidrug resistance (MDR) is a critical hindrance to the success of cancer chemotherapy. The main thing responsible for MDR phenotypes are plasma-membranes associated with adenosine triphosphate (ATP) Binding Cassette (ABC) drug efflux transporters, such as the P-glycoprotein (Pgp) transporter that has the broadest spectrum of substrates. Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable. To overcome these limitations, we validated the efficacy and safety of CURC, loaded in biocompatible solid lipid nanoparticles (SLNs), with or without chitosan coating, with the goal of increasing the stability, homogeneous water dispersibility, and cellular uptake. Both CURC-loaded SLNs were 5–10-fold more effective than free CURC in increasing the intracellular retention and toxicity of doxorubicin in Pgp-expressing triple negative breast cancer (TNBC). The effect was due to the decrease of intracellular reactive oxygen species, consequent inhibition of the Akt/IKKα-β/NF-kB axis, and reduced transcriptional activation of the Pgp promoter by p65/p50 NF-kB. CURC-loaded SLNs also effectively rescued the sensitivity to doxorubicin against drug-resistant TNBC tumors, without signs of systemic toxicity. These results suggest that the combination therapy, based on CURC-loaded SLNs and doxorubicin, is an effective and safe approach to overcome the Pgp-mediated chemoresistance in TNBC.

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“…In these results, the protein and carbohydrate contents are stood, which make turmeric a perfect nutritional alternative to be used as food, in addition to its use as a dye, spice, and flavorings in food preparations [18]. Rajkumari et al published a review in which they highlight that the nutritional value of 16 turmeric species lies in their protein, carbohydrate, and dietary fiber content [33].…”

Section: Antioxidant Activity Assaymentioning

confidence: 99%

“…Llano et al have gathered research results on the reaction mechanisms for the antioxidant activity, concluding that there are two possible mechanisms: Hydrogen atom transfer (HAT) and single electron transfer (SET). The electronic structure of the molecule could be described by both mechanisms [18]. On the other hand, it has been reported that the plant grown is strongly influenced by the manure in soils.…”

mentioning

confidence: 99%

Determination of nutritional value of turmeric flour and the antioxidant activity of Curcuma longa rhizome extracts from agroecological and conventional crops of Valle del Cauca-Colombia

Correa¹,

Osorio²,

Zúñiga³

et al. 2020

Rev. colomb. quim.

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This research presents the results of the proximal analysis of turmeric rhizome flour (Curcuma longa) from different areas of Valle del Cauca (Colombia) and the quantitative estimation of the uptake of the radical 2,2-diphenyl-1-Picrylhydrazyl (DDPH) of the methanolic extracts of the flour. The results of the proximal analysis evidence that some parameters do not show evident differences. However, others, such as total fat, show differences between the turmeric crops with conventional and agroecological fertilization. The values obtained from the different samples for proteins and carbohydrates are in an average normal range (9.3% and 70.5%, respectively), which fulfills the requirement to be a nutritional supplement. The free radical uptake (FRS) test of the extracts showed an antioxidant activity of the different samples tested for FRS50 (%) of 2.11 ± 0.06 µg / mL (Yumbillo, Y), 1.34 ± 0.26 µg / mL (Guacas, G), 4.22 ± 0.06 µg / mL (Magdalena, M), 9.16 ± 0.32 µg / mL (Commercial, C), 1.29 ± 0.26 µg / mL (Santa Rosa de Tapias, SR), and 1.33 ± 0.05 µg / mL (Limonar, L), which were contrasted with the values of quercetin (Q) 1.01 ± 0.51 µg / mL, vitamin C (V) 2.07 ± 0.45 µg / mL, and piperine (P ) (0,0) µg / mL. The proximal nutritional value plus the oxidizing activity, due to the concentration of phenolic compounds, make turmeric flour a functional food.

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Antioxidant activity of curcuminoids

Abstract: The antioxidant activity of the keto and enol forms of curcuminoids isolated from the roots of Curcuma longa is directly related to CH3O⋯H–O and NOT to CO⋯H–O hydrogen bonds.

Cited by 60 publications

References 38 publications

Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K+ channels pathway

Anti-allodynic effect induced by curcumin in neuropathic rat is mediated through the NO-cyclic-GMP-ATP sensitive K+ channels pathway

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells

Determination of nutritional value of turmeric flour and the antioxidant activity of Curcuma longa rhizome extracts from agroecological and conventional crops of Valle del Cauca-Colombia

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