Antioxidant Activity of Euphorbia hirta Linn Leaves Extracts

Sivaji, Asha; Thirunavukkarasu, P.S.; Mani, Vellingiri Manon; Sadiq, Abdul

doi:10.9734/ejmp/2016/24952

Cited by 16 publications

(13 citation statements)

References 59 publications

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“…In fact, antioxidant activities of aqueous extract of E. hirta are found to be comparable to that of green and black tea [31]. Other workers also reported significant scavenging activity of aqueous extract [32,33]. Out of the three extracts prepared in organic solvents, acetonic extract showed maximum activity which again corresponds to its high phenolic content.…”

Section: Total Phenolic Contentmentioning

confidence: 91%

Antibacterial, Antioxidant Activity and Phytochemical Analysis of Euphorbia hirta Linn.

Jakhar¹,

Dahiya²

2017

MRJI

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Objective: Crude extracts were prepared from aerial parts of Euphorbia hirta Linn. in four solvents i.e. water, acetone, ethanol and petroleum ether. Extracts were investigated for their phytochemical, antibacterial and antioxidant properties. Methods: Plant extracts were prepared by using Soxhlet apparatus. Antibacterial potential was assessed by disc diffusion method against six bacterial strains viz. Klebsiella pneumoniae (MTCC NO 109), Staphylococcus aureus (MTCC NO 96), Pseudomonas aeruginosa (MTCC NO 2453), Mycobacterium smegmatis (MTCC NO 992), Bacillus subtilis (MTCC NO 2057) and Chromobacterium violaceum (MTCC NO 2656). Minimum inhibitory concentration was determined by microbroth dilution method, only to those bacterial strains which showed a significant zone of inhibition by disc diffusion method. The extracts were also examined for the presence of various phytoconstituents, total phenolic and flavonoid content using standard methods. Free radical scavenging activity was assessed by DPPH method. Results: The plant extracts showed a wide spectrum of inhibition against the test pathogens thus justifying the use of plant in traditional medicine. Acetone, aqueous and ethanol extracts exhibited stronger antibacterial activity as compared to the petroleum ether extract. The maximum activity recorded was 17.6±0.57 mm with 200 mg/ml concentration of ethanol extract against

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Section: Total Phenolic Contentmentioning

confidence: 91%

Antibacterial, Antioxidant Activity and Phytochemical Analysis of Euphorbia hirta Linn.

Jakhar¹,

Dahiya²

2017

MRJI

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“…In our study total phenol content and total flavonoid content was calculated as 288.10 mgGAE/g and 29.36 mg QE/g respectively. In a study conducted by Basma et al [32] .120 mgQE/g, respectively. A similar study conducted by Asha S et al [33] determined total phenol content as 275.64 mgGAE/g, 291 .74 mgGAE/g, and 285.41 mgGAE/g in aqueous, ethanolic, and methanolic extract respectively, and total flavonoid content as 26.37 mg QE/g, 40.32 mg QE/g, and 32.29 mgQE/g in aqueous, ethanolic and methanolic extract respectively.…”

Section: In-vitro Anti-inflammatory Actionmentioning

confidence: 96%

“…Some of these plants are important sources of natural antioxidants that have been shown to reduce the risk and progression of certain acute and chronic diseases such as cancer, heart diseases, and stroke by scavenging free radicals which are impetrated in the pathogens us of many diseases [31]. Many studies suggest that polyphenols and flavonoids exert antioxidant and anti-inflammatory activities by scavenging hydroxyl radicals, superoxide anions, and lipid peroxy radicals [31][32]. In our study total phenol content and total flavonoid content was calculated as 288.10 mgGAE/g and 29.36 mg QE/g respectively.…”

Section: In-vitro Anti-inflammatory Actionmentioning

confidence: 99%

Phytochemical Screening and In Vitro Antioxidant and Anti-inflammatory Activities of Aerial Parts of Euphorbia hirta L.

Basyal

Neupane

Pandey

et al. 2021

J. Nepal Chem. Soc.

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Euphorbia hirta L (Euphorbiaceae) also called asthma herb has long been prescribed in traditional medicine because it exhibits diverse pharmacological actions due to the presence of alkaloids, flavonoids, polyphenols, triterpenoids, and saponins. The present study is aimed at the study of phytochemical and antioxidant activity and anti-inflammatory screening of E. hirta. Extraction of dried powder was performed followed by phytochemical screening using color reactions. Total phenolic content (TPC) and total flavonoid content (TFC) of the extracts were estimated by Folin-Ciocalteu and Aluminum chloride method respectively. The antioxidant activity was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Anti-inflammatory activity was studied by using protein denaturation in vitro bioassay. Phytochemical screening showed the presence of flavonoids, alkaloids, and phenolic compounds. TPC, TFC and antioxidant activity (IC50) of the extract were found as 288.10 mg gallic acid equivalent per gram (GAE/g), 29.36 mg quercetin equivalent per gram (QE/g) and 32.23 µg/mL (p<0.05) respectively. Diclofenac sodium and E. hirta extract showed the maximum inhibition of 91.28% and 68.20% respectively at the concentration of 1000 µg/mL compared with control (p>0.05). The phenolic compounds and flavonoids exert antioxidant and anti-inflammatory activities because of their scavenging ability. The demonstrated antioxidant and anti-inflammatory activities may be the rationale behind some of its folkloric uses and also may be responsible for some of its pharmacological effects. Thus, E. hirta can be considered a good source of antioxidants and anti-inflammatory actions, which might be beneficial for combating oxidative stress.

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“…The ethanolic extract of P. niruri contained a total of 81.59 ± 2.85 mg phenolic equivalent to gallic acid/g extract (Da'i et al, 2016). The study of E. hirta leaf extract showed that the ethanolic extract contained a higher level of phenolic compounds (291.74±2.46 mg gallic acid equivalent/g extract) and flavonoids (40.32±1.67 mg quercetin equivalent/g extract) compared to methanol and water extracts (Asha et al, 2016).…”

Section: Bmentioning

confidence: 97%

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

Kristiani

Kasmiyati

2021

J Bio Bio Edu

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Meniran (Phyllanthus niruri), patikan kebo (Euphorbia hirta), and benalu (Loranthus sp.) have often been used by people as medicinal plants. This research aimed to measure the levels of flavonoids, phenolics, and ascorbic acid compounds, as well as the Free Radical Scavenging (FRS) activity of ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. The FRS activity was measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The level of compounds was measured by using the spectrophotometry method with specific reagents. The result of the FRS activity in ethyl acetate extract from the mixture of P. niruri, E. hirta, and Loranthus sp. varied depending on its dose. The measure of FRS in the P. niruri: E. hirta: Loranthus sp 0:0:1 (K-OOL) composition showed a strong result with a value of IC50 97.2 ± 2.1 ppm, while in the 0:0.5:0.5 (K-OEL) composition it was moderate with a value of IC50 147.6 ± 6.5 ppm. The other compositions showed weak and inactive results. The K-OOL composition had the highest flavonoid and phenolic content that were 298.8±0.00 mg QE/g extract and 141.5±2.85 mg GAE/g extract respectively. The composition with the highest ascorbic acid content (298.8±0.00 mg/g extract) was K-OEO composition. So far, research on medicinal plants is still limited to one type of plant. The combination of several types of plants in several formulations allows obtaining a composition that can produce maximum antioxidant capacity. Therefore, this research is expected to produce a combination formulation of various types of medicinal plants that have the K-OOL composition very strong antioxidant activity and can be used as herbal medicines.

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Antioxidant Activity of Euphorbia hirta Linn Leaves Extracts

Cited by 16 publications

References 59 publications

Antibacterial, Antioxidant Activity and Phytochemical Analysis of Euphorbia hirta Linn.

Antibacterial, Antioxidant Activity and Phytochemical Analysis of Euphorbia hirta Linn.

Phytochemical Screening and In Vitro Antioxidant and Anti-inflammatory Activities of Aerial Parts of Euphorbia hirta L.

The Combination of Phyllanthus niruri, Euphorbia hirta, and Loranthus sp. as a Source of Antioxidant Agents

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