Antioxidant activity of flavonoids: Efficiency of singlet oxygen (1Δg) quenching

Tournaire, Cécile; Croux, Sylvie; Maurette, Marie-Thérèse; Beck, I.; Hocquaux, M.; Braun, André M.; Oliveros, Esther

doi:10.1016/1011-1344(93)87086-3

Cited by 239 publications

(188 citation statements)

References 33 publications

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“…These results are in agreement with the previously shown high chemical reactivity of flavonols with 1 O 2 , explained by the presence of the C3-OH substituent in the C-ring. 34 Nevertheless, the most effective 2-styrylchromones (1A and 1C), although lacking this substituent, were quite as active as quercetin.…”

Section: Discussionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

129

173

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Abstract-2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC 50 s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

show abstract

Section: Discussionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

129

173

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show abstract

“…It is a potent physical quencher of singlet oxygen. Luteolin inhibits single strand break in DNA induced by singlet oxygen in a dose-dependent manner [20,21] . The antioxidant activity of methanolic and aqueous extracts of M. annua Linn.…”

Section: Discussionmentioning

confidence: 99%

“…This was left to stand for 10 min and then treated with Folin-Ciocalteau reagent that resulted in a bluish color in [20][21][22][23][24][25][26][27][28][29][30] min. The absorbance was measured in UV (Cintra) Spectrophotometer at 660 nm [14] .…”

Section: Protein Estimationmentioning

confidence: 99%

Preliminary pharmacological evaluation of Martynia annua Linn leaves for wound healing

Lodhi

Singhai

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Of particular importance to neurodegenerative diseases such as Parkinson's disease is the ability of flavonoids to inhibit peroxynitrite-mediated oxidation of dopamine and peroxynitrite-mediated nitration of tyrosine in vitro by a structure-dependent mechanism involving either the oxidation or nitration of the flavonoid ring system [98,150,151]. In addition, their ability to act as antioxidants in vitro is based on metal-chelating capacity [22,138] and on the quenching of singlet oxygen [203]. However, although flavonoids react rapidly with ROS/RNS in chemical systems in vitro, their reactions in vivo will be dependent on the form that is bioavailable to cells and tissues.…”

Section: Flavonoids: Antioxidant Propertiesmentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

310

178

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Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

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Antioxidant activity of flavonoids: Efficiency of singlet oxygen (1Δg) quenching

Cited by 239 publications

References 33 publications

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Preliminary pharmacological evaluation of Martynia annua Linn leaves for wound healing

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

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