Antioxidant activity of flavonoids from Sideritis raeseri

Gabrieli, Chrysi; Kefalas, Panagiotis; Kokkalou, Eugene

doi:10.1016/j.jep.2004.09.031

Cited by 75 publications

(73 citation statements)

References 21 publications

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“…The results are in agreement with previously studied Sideritis taxa belonging to section Epmedoclia: S. raeseri (Gabrieli et al, 2005), S. scardica (Sattar et al, 1993) and S. syriaca (Sattar et al, 1993).…”

Section: Resultssupporting

confidence: 93%

Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae)

Charami

Lazari

Karioti

et al. 2008

Phytotherapy Research

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Sideritis perfoliata L. subsp. perfoliata is a plant widely used in folk medicine in Greece since antiquity because of its antiinflammatory, antirheumatic, antiulcer, digestive and vasoprotective properties. Phytochemical investigations of the polar extracts afforded four flavonoid glycosides, four phenylpropanoic glycosides, caffeic acid and one iridoid, ajugoside. Reactive oxygen species (ROS) are implicated in the aetiology of several inflammatory processes. In the present study polar fractions and isolated compounds from S. perfoliata subsp. perfoliata were evaluated for their antioxidant activity using DPPH spectrophotometric and TBA lipid peroxidation assays, as well as for their antiinflammatory activity using the soybean lipoxygenase bioassay. All extracts and isolated compounds showed significant antioxidant and inhibitory activity against soybean lipoxygenase. These findings give support to the ethnopharmacological use of the plant in the treatment of several inflammatory ailments.

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Section: Resultssupporting

confidence: 93%

Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae)

Charami

Lazari

Karioti

et al. 2008

Phytotherapy Research

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“…Overall, the fragmentation pattern of this compound corresponded to that of isoscutellarein-7-O-(6-O-acetylallosyl)(1→ 2) glucoside. Moreover, this assignment was confirmed by NMR spectroscopy, as all the 1 H NMR and 13 C NMR signals (Table 3) were consistent with that isoscutellarein derivative (Albach, Grayer, Jensen, Ozgokce, & Veitch, 2003;Gabrieli, Kefalas, & Kokkalou, 2005;Sahin et al, 2006).…”

Section: Isoscutellarein Derivativessupporting

confidence: 74%

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L. album L. is far from being understood. In this study, a purified ethanolic extract (PEEL) was prepared and further analyzed by high performance liquid chromatography and electrospray mass spectrometry. Overall, verbascoside accounted for approximately half of the phenolic content of the extract, but this also contained other bioactive phenolic compounds herein detected for the first time in the genus, namely isoscutellarein derivatives. The latter included isoscutellarein-7-O-allosyl(1 →2)glucoside, its O-methyl derivative, three acetyl derivatives of isoscutellarein-Oallosyl glucoside and one acetylated form of O-methylisoscutellarein-7-O-allosyl(1 →2)glucoside. From those, the main isoscutellarein derivative was assigned to isoscutellarein-7-O-(6-O-acetyl-β-allosyl)(1→2)-β-glucoside, as confirmed by NMR. Altogether, isoscutellarein derivatives accounted for almost 30% of PEEL phenolics. Since verbascoside and isoscutellarein derivatives are main components of L. album L. ethanolic extract, their possible association to the health benefits of the plant is discussed.

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“…Similarly, IC 50 values of some of the extracts are also very close to those of ferulic acid, chlorogenic acid and α-tocopherol. However, it is usually observed in many studies that the aglycones have more antioxidant potency than their glycosylated and methylated forms, which were reported to exist more abundantly in various Sideritis species than their free forms (Kupeli, Sahin, Calis, Yesilada, & Ezer, 2007;Gabrielia, Kefalasb, & Kokkalou, 2005).…”

Section: Rosmarinic Acid B Ferulic Acid Caffeic Acid P-coumaric Acid mentioning

confidence: 99%

Antioxidant activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr: Identification of free flavonoids and cinnamic acid derivatives

Erkan

Çetin

Ayrancı́

2011

Food Research International

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Antioxidant activity of flavonoids from Sideritis raeseri

Cited by 75 publications

References 21 publications

Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae)

Antioxidant and antiinflammatory activities of Sideritis perfoliata subsp. perfoliata (Lamiaceae)

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Antioxidant activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr: Identification of free flavonoids and cinnamic acid derivatives

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