Antioxidant Activity of <i>Nepeta nuda</i> L. ssp. <i>nuda</i> Essential Oil Rich in Nepetalactones from Greece

Gkinis, George; Božin, Biljana; Mimica–Dukić, Neda; Τζακου, Ολγα

doi:10.1089/jmf.2009.0218

Cited by 24 publications

(16 citation statements)

References 26 publications

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“…N. nuda L. subsp. nuda essential oil being rich in 4aβ,7α,7aβ‐nepetalactone and eucalyptol possessed significant DPPH free radical scavenging effect (Gkinis, Bozin, Mimica‐Dukic, & Tzakou, ). On the other hand, Shakeri et al () reported that the essential oil of N. sintenisii Bornm.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

et al. 2019

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In the present study, the essential oil and aroma compositions of Nepeta heliotropifolia (NH) and N. congesta subsp. cryptantha (NC) were determined by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC/FID), and their phenolic compounds by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, antioxidant, cytotoxic, anticholinesterase, urease, and tyrosinase activities of essential oils obtained from NH and NC aerial parts and ethanol extracts prepared from different parts of NH and NC were investigated. The major constituent of water-distilled essential oils was found to be germacrene D (36.7% and 38.5%, respectively), and their main aroma component was eucalyptol (48.0% and 24.7%, respectively). Among the studied parts of NH and NC, their flowers extracts were found to be the richest in phenolic compounds and in which the most abundant compound was rosmarinic acid (8,909.91 and 4,317.20 μg/g, respectively). NH and NC flower extracts exhibited also strong antioxidant activity in DPPH, ABTS, and CUPRAC assays. Among the tested samples, NH essential oil indicated the best cytotoxic effect against PDF, HT-29, and MCF-7 (IC 50 52.34, 25.89, and 44.70 μg/ml, respectively), and the highest butyrylcholinesterase (77.21 ± 1.12% inhibition) and moderate acetylcholinesterase (41.36 ± 0.69% inhibition) inhibitory activities. Practical applicationsThis is the first report on the essential oil and aroma compositions, the phenolic compounds, the antioxidant with total phenolic and flavonoid contents, cytotoxic, anticholinesterase, urease, and tyrosinase activities of Nepeta heliotropifolia and N. congesta subsp. cryptantha, except for their essential oil compositions. The reported results suggested that Nepeta heliotropifolia and N. congesta subsp. cryptantha flowers being rich in rosmarinic acid and having strong antioxidant potential, and NH essential oil possessing significant cytotoxic and butyrylcholinesterase inhibitory effect could be source for nutraceutical, food, and drug industries. K E Y W O R D Saroma, biological activities, essential oil, LC-MS/MS, Nepeta, phenolic compound 2 of 12 | AKDENIZ Et Al.

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Section: Resultsmentioning

confidence: 99%

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

et al. 2019

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“…It was documented that nepetalactones were the predominant components responsible for the feline attractant properties of many Nepeta species, such as N. persica, N. pogonosperma, N. racemosa, N. cataria, N. sibirica, N. nuda, N. grandifolia, N. clarkei, N. argolica and N. crassifolia. [34][35][36][37][38][39][40][41] For instance, 4aα,7α,7aβ-nepetalactone (28.8%) and 4aα, 7β,7aα-nepetalactone (11.9%) were reported the major components of Nepeta cataria essential oil. [41] Tittel et al [42] reported that the main constituents of N. cataria var.…”

Section: Resultsmentioning

confidence: 99%

Essential oil composition of seven populations belonging to twoNepetaspecies from Northwestern Iran

Narimani

Moghaddam

Pirbalouti

et al. 2017

International Journal of Food Properties

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Essential oils from the aerial parts of three populations of Nepeta crassifolia (Lamiaceae), which are Iranian endemic species and four populations of N. nuda grown in northwestern Iran were obtained by hydro-distillation and examined by gas chromatography (GC) and GC-mass spectrometry (GC/ MS). Overall, 37 compounds were identified in the essential oils from different populations of N. crassifolia and N. nuda. The essential oils consisted mainly of oxygenated monoterpenes and sesquiterpene aldehydes. The major components in the oils of three populations of N. crassifolia were 4aβ, 7α, 7aβ-nepetalactone (16.46-27.45%), 4aα, 7α, 7aβ-nepetalactone (13.45-17.54%), 1,8-cineole (8.15-9.70%) and elemol (14.38-22.14%), while 7aβ-nepetalactone (61-72.21%), 4aα, 7α, 7aβ-nepetalactone (8.72-12.63%), pulegone (7.36%) and piperitenone oxide (4.12%) were identified as the main constituents in the oils of four populations of N. nuda. The essential oils from the aerial parts of two species of Nepeta sourced in northwestern Iran were rich in oxygenated monoterpenes. In conclusion, the present study indicated the essential oil components of wild populations of both Nepeta species varied with chemotypes, environmental conditions, and geographic origin.

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“…BMT: branchlets of male tree; BFT: branchlets of female tree. (Pérez et al, 2006;Gkinis et al, 2010;Miguel et al, 2010). Although the net effect of all oils at all tested concentrations was inhibitory, such a concentrationdependent dual activity could be hypothesized for some of the constituents of J. oblinga oils which leads to the aforementioned inverse association.…”

Section: Insulin Glycationmentioning

confidence: 95%

Investigation of antioxidant and anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga

Emami¹,

Asgary²,

Naderi³

et al. 2012

Rev. bras. farmacogn.

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Plants represent the best and most extensively studied source of natural antioxidants. The present study investigated the antioxidant and anti-glycation properties of different concentrations of essential oils obtained from fruits and branchlets of Juniperus oblonga M. Bieb., Cupressaceae, using different assays. The essential oils were obtained by steam distillation of the branchlets of male tree (BMT), branchlets of female tree (BFT) and fruits of J. oblonga. Compositional analysis of oils was performed using a gas chromatography-mass method. Antioxidant activity was assessed using linoleic acid peroxidation, peroxyl radical mediated hemolysis of red blood cells (RBC) and low-density lipoprotein (LDL) oxidation assays. Anti-glycation properties of oils were evaluated using hemoglobin and insulin glycation assays. Seventeen, eighteen and fi fteen compounds were identifi ed in the BMT, BFT and fruit oil, which represented 82.51, 55.69 and 96.89% of the total oils, respectively. α-Pinene was the major component of all three oils. All three oils possessed antioxidant effects against LDL oxidation, linoleic acid peroxidation and peroxyl radical mediated RBC hemolysis. Anti-glycation activities against hemoglobin and insulin glycation were also observed from all tested oils. Overall, there was no unique pattern of dose-dependence for the antioxidant properties of oils in different employed systems. The fi ndings of this study suggest that essential oils from fruits and branchlets of J. oblonga possess antioxidant and anti-glycation properties. Therefore, these oils might be of therapeutic effi cacy against diabetes and cardiovascular disease.

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Antioxidant Activity of Nepeta nuda L. ssp. nuda Essential Oil Rich in Nepetalactones from Greece

Cited by 24 publications

References 26 publications

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

Essential oil composition of seven populations belonging to twoNepetaspecies from Northwestern Iran

Investigation of antioxidant and anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga

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