Antioxidant activity of low molecular weight alginate produced by thermal treatment

Kelishomi, Zahra Habibi; Goliaei, Bahram; Mahdavi, Hossein; Nikoofar, Alireza; Rahimi, Monireh; Moosavi-Movahedi, Ali Akbar; Mamashli, Fatemeh; Bigdeli, Bahareh

doi:10.1016/j.foodchem.2015.09.091

Cited by 118 publications

(52 citation statements)

References 38 publications

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“…In this particular stance, D10 presents with 10 kDa, while D40 and D147 present with 40 and 147 kDa, respectively. We chose these dextrans because they represent dextran molecules with low, medium and high molecular mass, respectively, in agreement with other papers that evaluated the influence of the molecular weight in the polysaccharides activity [19,20,21,22,23]. In addition, we did not used dextrans of higher molecular weights like 300 or 500 kDa or even higher because they showed very low water solubility, as well as because they could break during the tests and their fragments could alter the overall result.…”

Section: Resultsmentioning

confidence: 99%

“…Several groups showed the relationship between molecular weight ( M W ) and pharmacological activities of polysaccharides including fucans [19], alginates [20], hyaluronic acid [21] and glucans. For instance, Zho et al [22], working with two β-glucans, showed that high molecular weight β-glucan (552 kDa) inhibits differentiation of 3T3-L1 pre-adipocytes stronger than that of low molecular weight β-glucan (32 kDa).…”

Section: Introductionmentioning

confidence: 99%

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Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Soeiro

Melo

Alves

et al. 2016

IJMS

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Dextrans (α-d-glucans) extracted from Leuconostoc mesenteroides, with molecular weights (MW) of 10 (D10), 40 (D40) and 147 (D147) kDa, were evaluated as antioxidant, anticoagulant and immunomodulatory drugs for the first time. None presented anticoagulant activity. As for the antioxidant and immunomodulatory tests, a specific test showed an increase in the dextran activity that was proportional to the increase in molecular weight. In a different assay, however, activity decreased or showed no correlation to the MW. As an example, the reducing power assay showed that D147 was twice as potent as other dextrans. On the other hand, all three samples showed similar activity (50%) when it came to scavenging the OH radical, whereas only the D10 sample showed sharp activity (50%) when it came to scavenging the superoxide ion. D40 was the single dextran that presented with immunomodulatory features since it stimulated the proliferation (~50%) of murine macrophages (RAW 264.7) and decreased the release of nitric oxide (~40%) by the cells, both in the absence and presence of lipopolysaccharides (LPS). In addition, D40 showed a greater scavenging activity (50%) for the hydrogen peroxide, which caused it to also be the more potent dextran when it came to inhibiting lipid peroxidation (70%). These points toward dextrans with a 40 kDa weight as being ideal for antioxidant and immunomodulatory use. However, future studies with the D40 and other similarly 40 kDa dextrans are underway to confirm this hypothesis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Soeiro

Melo

Alves

et al. 2016

IJMS

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“…The almost 15% increase of the observed protection could be explained by synergistic action of drug and alginate. There are several reports demonstrated antioxidant action of alginates from different sources [46,47]. Noguchi et al discovered that Eb suppressed the oxidation of methyl linoleate emulsions in aqueous dispersions induced by iron [48] suggesting that this effect is a result of antioxidant action of drug due to reducing hydroperoxides, which probably takes also place in our system.…”

Section: Discussionmentioning

confidence: 68%

Topical Delivery of Ebselen Encapsulated in Biopolymeric Nanocapsules: Drug Repurposing Enhanced Antifungal Activity

Jaromin

Żarnowski

Pįętka-Ottlik

et al. 2018

Nanomedicine (Lond.)

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Aim: Ebselen (Eb) is an example of a repurposed drug with poor aqueous solubility which requires sophisticated delivery system such as nanoencapsulation in nanocapsules for topical application. Materials & methods: Eb-nanocapsules were examined for morphology, activity against Candida spp., cytotoxicity and skin permeation. Results: Eb-nanocapsules were active against skin-infecting Candida tropicalis, Candida albicans and Candida parapsilosis yeasts (minimal inhibitory concentration values were about 4-, 2-and 1.25-times lower vs free Eb, respectively) and able to suppress induced lipid oxidation in the oil/water emulsion. Moreover, demonstrated minimal toxicity in normal human dermal fibroblast cell line, whereas ex vivo skin permeation studies showed no transdermal passage and strong interactions with stratum corneum. Conclusion: Eb-nanocapsules represent a promising, safe and complementary alternative to the treatment of cutaneous candidiasis.

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“…Antioksidan semula jadi dan sintetik telah digunakan untuk menghalang pembentukan radikal bebas. Pelbagai usaha telah dijalankan bagi mencari sumber antioksidan semula jadi yang lebih selamat berikutan isu antioksidan sintetik seperti BHA dan BHT yang dikatakan mempunyai pelbagai kesan sampingan (Kelishomi et al 2016). Ciri alginat yang tidak toksik dan boleh terbiodegradasi mendorong para penyelidik untuk mengkaji lebih dalam tentang sifat antioksidan alginat.…”

Section: Pengenalanunclassified

Kesan Kaedah Pemendakan Berbeza terhadap Ciri Fizikokimia dan Aktiviti Antioksidan Alginat daripada Sargassum sp.

Lim

Khalafu

Mustapha³

2017

JSM

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Antioxidant activity of low molecular weight alginate produced by thermal treatment

Cited by 118 publications

References 38 publications

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Topical Delivery of Ebselen Encapsulated in Biopolymeric Nanocapsules: Drug Repurposing Enhanced Antifungal Activity

Kesan Kaedah Pemendakan Berbeza terhadap Ciri Fizikokimia dan Aktiviti Antioksidan Alginat daripada Sargassum sp.

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