Antioxidant activity of n-butanol extract of celery (Apium graveolens) seed in streptozotocin-induced diabetic male rats

Al-Sa#;aidi, A.

doi:10.5897/rpb12.002

Cited by 32 publications

(23 citation statements)

References 41 publications

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“…It was shown that the antioxidant activity of hydroalcoholic leaf extract of celery decreased the lipid profile in rats on a high-fat diet (20). It was also reported in another study (22) that a reduction in blood glucose and activity increased the enzyme activity of superoxide dismutase, catalase, and glutathione reductase. However, a significant increase in alanine transaminase and aspartate transaminase levels in diabetic rats treated with n-butanol extract of celery was not found (22).…”

Section: The Role Of Antioxidantsmentioning

confidence: 93%

Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Ebrahimi

Shirali

Afrisham

2016

Jundishapur J Nat Pharm Prod

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Context: Diabetes mellitus is the most common endocrine disease worldwide and its prevalence is increasing. The development of drugs with fewer side-effects is required when treating this disease. Thus, the objective of this study was to evaluate the use of traditional medicine and medicinal plants in this regard. The various mechanisms by which isolated extracts and herbal compounds exert their effects on different diabetes mellitus factors was investigated. Evidence Acquisition: Databases such as PubMed, Science Direct, and Web of Science (from 1990 until the present) were searched, using a detailed list of terms related to the effects and mechanism of herbal ingredients on diabetes mellitus complications. Results:The presence of secondary metabolites, such as phenols, flavonoids and alkaloids in plants, have been used as a source of medication for the treatment of many diseases, including diabetes mellitus. Following an extensive review of the literature, it was found that the secondary metabolites of plants have a wide range of anti-diabetic effects. Conclusions: Plant compounds should be isolated and their effects on diabetes mellitus and its complications examined in order to treatment for diabetes mellitus.

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Section: The Role Of Antioxidantsmentioning

confidence: 93%

Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Ebrahimi

Shirali

Afrisham

2016

Jundishapur J Nat Pharm Prod

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“…In another study, superoxide dismutase (SOD), CAT, GSH‐transferase, GSH‐reductase, and GSH have been studied. It showed that administration of n‐butanol extract of celery seed (n‐B extract) in rats increased subcellular GSH content and activity of SOD and CAT as two major scavenging enzymes and inhibited LPx (Al‐Sa'aidi, Alrodhan, & Ismael, ). In addition, for evaluation of the effects of celery on hyperglycemia, blood samples were collected and the mean blood glucose level and fasting plasma insulin levels were evaluated.…”

Section: Effects On Hyperglycemiamentioning

confidence: 99%

“…Also, the elevated levels of serum insulin and HDL were observed. In the histopathological evaluation, this compound showed protective activities and decrease in the number of Langerhans islets (Al‐Sa'aidi et al, ). The hypolipidemic effect of linalool as an aromatic monoterpene present in celery was investigated.…”

Section: Effects On Hyperlipidemiamentioning

confidence: 99%

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Hedayati

Naeini

Mohammadinejad

et al. 2019

Phytotherapy Research

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The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta‐carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.

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“…Celery was also known to have anthelmintic effect if administered 1.2 to 4.0 g daily dosage of the seeds and 23 g or 15 ml 3 times daily juice of the fresh plant. 33 Celery fruit (seed) extracts are broadly employed as a flavoring agent in many food products, such as candies, frozen dairy desserts, baked goods, meat products, soups, puddings, gelatins, alcoholic and non-alcoholic beverages, condiments and relishes, snack foods, and others. 34 The seeds are bitter and have burning sensation.…”

Section: Nephrotoxicity Studymentioning

confidence: 99%

Pharmacognostical, Pharmacological and Traditional Perspectives of Apium Graveolens: An Ethnomedicinal Plant

Gupta

Mathur

2019

Int J Life Sci Pharm Res

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Apium graveolens (Hindi name: Celery) belongs to family Apiaceae of order Apiale and is a biennial plant. It is about 25-250 cm in height and found in western Uttar Pradesh, northwestern Haryana, Punjab, Himalayas and in some parts of Europe. Fourocoumarin, coumarin and phenols are main categories of phytoconstituents present in it. Celerin, bergaten, aiumoside, aimuetin, aigravin, osthenol, seselin are the main active phytoconstituents of active constituents. Different parts of the plant have various medicinal applications such as antibacterial activity, cardiovascular activity, antidiabetic activity, anti-depressant activity, hypolipidemic effect, effect on kidney, effects on male hormones, spermatogenesis and cytoprotective activity etc. The present review aims at the exploration of pharmacognostical, phytochemical and pharmacological studies of celery. Finally, the review concludes that this would be significantly and scientifically useful for both professional of academia and pharmaceutical industry those are doing research on this plant.

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Antioxidant activity of n-butanol extract of celery (Apium graveolens) seed in streptozotocin-induced diabetic male rats

Cited by 32 publications

References 41 publications

Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Effect and Mechanism of Herbal Ingredients in Improving Diabetes Mellitus Complications

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Pharmacognostical, Pharmacological and Traditional Perspectives of Apium Graveolens: An Ethnomedicinal Plant

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