Antioxidant Activity of Natural Products Isolated from Red Seaweeds

Nogueira, Caio Cesar Richter; Paixão, Izabel Christina Nunes de Palmer; Teixeira, Valéria Laneuville

doi:10.1177/1934578x1400900737

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…25 Accumulating evidences demonstrate the powerful antioxidant activity of many natural products. 26–28 An optimal level of reactive oxygen species (ROS) is essential for regulation of cellular processes. However, excessive ROS generation is harmful to biomolecules and induces oxidative stress in various chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

Annona atemoyaleaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model

Lim

Kim

Sohn

et al. 2019

Exp Biol Med (Maywood)

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Annona atemoya is a hybrid of Annona squamosa and Annona cherimola that grow in several subtropical or tropical areas such as Florida in the US, Philippines, Cuba, Jamaica, Taiwan, and Jeju in South Korea. We report that the A. atemoya leaves (AAL) have inhibitory effects on the pathogenesis and regulatory mechanisms of Alzheimer’s disease (AD). Ethanol extract of AAL prevented amyloid-β (Aβ) aggregation and increased free radical scavenging activity. In addition, AAL extract exerted protective effects against neuronal cell death in HT22 hippocampal cells. Moreover, oral administration of AAL extract significantly improved memory loss in the passive avoidance task and Y-maze test, as well as downregulated the expression of neuronal markers neuronal nuclei and brain-derived neurotrophic factor in Aβ-injected AD mice. To verify the molecular mechanisms responsible for anti-AD actions of AAL, we conducted the antibody microarray analysis and found that epidermal growth factor receptor/G protein-coupled receptor kinase 2 signaling was activated in neuronal cells and AD-like mouse models. Additionally, quantitative analyses of the six standard compounds using high-performance liquid chromatography revealed that rutin is the most abundant compound of AAL. Furthermore, efficacy analyses of six standard compounds showed that rutin and isoquercitrin had significant inhibitory activity on Aβ aggregation. Taken together with biological activity and the content of compounds, rutin maybe a bioactive compound of AAL in the AD pathogenesis. Overall, our findings provide the first scientific support for the therapeutic effects of AAL in AD and AD-related disorders. Impact statement Our study was aimed to find a novel candidate drug for Alzheimer’s disease (AD) using natural products. We assessed the effects of Annona atemoya extracts on crucial events in the pathogenesis of AD. A. atemoya leaf (AAL) extract significantly inhibited amyloid-β aggregation, oxidative stress, neuronal cell death, and memory impairment through the epidermal growth factor receptor/G protein-coupled receptor kinase 2 pathway. Simultaneous analysis using HPLC determined six standard compounds of AAL extract, and rutin was identified as a bioactive compound. Of note, the anti-AD activity of AAL extract was more significant compared to other extracts from medicinal plants of which efficacy was previously reported. The potential of AAL extract as an anti-AD agent may provide insight into the new drug development for AD treatment.

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Section: Discussionmentioning

confidence: 99%

Annona atemoyaleaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model

Lim

Kim

Sohn

et al. 2019

Exp Biol Med (Maywood)

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“…For example, mycosporine-like amino acids isolated from Ahnfeltiopsis devoniensis show antioxidant activity [99]. Moreover, two classes of natural compounds, polyphenols and bromophenols, with known antioxidant activity were isolated from red seaweeds [100]. The ethanolic [101] and methanolic [102] extracts isolated from Gracilaria tenuistipitata showed antiproliferative activity on the oral carcinoma cell line Ca 9-22 by modulating oxidative-stress-induced cell apoptosis.…”

Section: Metabolites With Potential Beneficial Activities From Marmentioning

confidence: 99%

Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology

et al. 2019

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Marine organisms produce a large array of natural products with relevance in drug discovery. These compounds have biological activities such as antioxidant, antibacterial, antitumor, antivirus, anticoagulant, anti-inflammatory, antihypertensive, antidiabetic, and so forth. Consequently, several of the metabolites have made it to the advanced stages of clinical trials, and a few of them are commercially available. In this review, novel information on natural products isolated from marine microorganisms, microalgae, and macroalgae are presented. Given due research impetus, these marine metabolites might emerge as a new wave of promising drugs.

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“…From red alga belonging to the family Rhodomelaceae (in the order of Ceramiales), e.g. genera of Rhodomela, Symphyocladia, Polysiphonia, Vetebrata, and Odonthalia, a number of antioxidant and anti-inflammatory bromophenols have been reported (Choi et al, 2018;Gribble, 2015;Jesus et al, 2019;Nogueira et al, 2014;Wang et al, 2013;Wiemer et al, 1991). However, the genus Ceramium which is in the family Ceramiaceae (Ceramiales), has only been investigated cursorily for its natural products.…”

Section: Introductionmentioning

confidence: 99%

Monomeric and Dimeric Bromophenols from the Red Alga Ceramium Sp. with Antioxidant and Anti-Inflammatory Activities

Zhang¹,

Glukhov²,

Yu³

et al. 2020

Preprint

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LC-MS2-based molecular networking using the Global Natural Products Social (GNPS) tool revealed a rich assortment of brominated compounds present in the antioxidant fraction of a red algal extract (Ceramium sp.) Further chemical investigation led to discovery of one monomeric bromophenol (lanosol isopropyl ether, 1) and seven dimeric ones (bromourceolatols A-G, 2-8), all of which are previously undescribed. Their structures were elucidated by extensive analysis of their spectroscopic data. Compounds 2-8 were determined to be racemic trans-type isomers by NOESY, specific optical rotation, and ECD. Compounds 1 and 3 displayed antioxidant activity with their EC50 of 44.4 and 47.0 μM, respectively, for scavenging DPPH free radicals while compounds 2 and 4 had approximate EC50 values of ~ 64 μM. Furthermore, compounds 2, 3, and 7 exhibited relatively potent anti-inflammatory activity at 32 μM by quenching 97%, 47%, and 73% of nitric oxide induced by bacterial lipopolysaccharide in macrophage RAW264.7 cells, respectively.

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Antioxidant Activity of Natural Products Isolated from Red Seaweeds

Cited by 8 publications

References 47 publications

Annona atemoyaleaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model

Annona atemoyaleaf extract ameliorates cognitive impairment in amyloid-β injected Alzheimer’s disease-like mouse model

Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology

Monomeric and Dimeric Bromophenols from the Red Alga Ceramium Sp. with Antioxidant and Anti-Inflammatory Activities

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