Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Krishnamoorthy, Gayathri; Chellappan, David Raj; Joseph, Jipnomon; Ravindhran, Dhevi; Shabi, Mohamed M.; Uthrapathy, Subashini; Rajamanickam, Victor; Dubey, Govind Prasad

doi:10.1590/s0102-695x2009000200008

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Our developed polyherbal combination does ameliorate oxidative markers. Previous reports of reduction in the oxidative markers with B. diffusa (Pareta et al 2011b), R. emodi (Chang and Kim 2018), N. nucifera (Krishnamoorthy et al 2009) and C. nurvala (Shirwaikar et al 2004) are in line with the current findings. The antioxidant effect of the constituent ingredients seems to contribute to the overall nephroprotective action of the polyherbal combination.…”

Section: Discussionsupporting

confidence: 93%

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Sharma

Baboota

Amin

et al. 2020

Pharmaceutical Biology

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Context: Nephrotoxicity is a renal dysfunction that arises from direct exposure to environmental chemicals or as a side effect of therapeutic drugs. Boerhaavia diffusa Linn. (Nyctaginaceae), Rheum emodi Wall. Ex. Meissn. (Polygonaceae), Nelumbo nucifera Gaertn. (Nelumbonaceae) and Crataeva nurvala Buch-Ham. (Capparidaceae) are well-recognized medicinal plants of Indian traditional system of medicine used for kidney disorders.Objectives: The present investigation was undertaken to develop a chromatographically characterized polyherbal combination and to evaluate its nephroprotective activity. Materials and methods: Roots of B. diffusa and R. emodi, flowers of N. nucifera and stem bark of C. nurvala were extracted by decoction using 70% ethanol. Response surface methodology (RSM) was used for the optimization of extraction parameters. Polyherbal combinations with different doses (150-300 mg/kg) were tested against methotrexate-induced nephrotoxicity in Wistar rats. Results: The optimized extract contained 27% phenols and 15% flavonoids, which showed 75% 1, 1diphenyl-2-picryl-hydrazyl (DPPH) scavenging potential. Based on the retention time of high-performance liquid chromatography (HPLC) analysis, 17 out of 122 constituents were found common in all extracts and combinations. Two combinations showed significantly higher (p 0.05) DPPH scavenging potential and xanthine oxidase inhibition. The half maximal inhibitory concentration (IC 50 ) of the best combination for DPPH scavenging and xanthine oxidase inhibition were 80 and 74 mg/mL, respectively. Treatment of methotrexate-induced nephrotoxic rats with polyherbal combination significantly (p 0.05) improved the kidney function markers, oxidative stress markers and histological parameters. Discussion and conclusion: The developed combination was found to be effective in nephrotoxicity; it can be explored further for the management of drug-induced nephrotoxicity and other chronic kidney diseases. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 93%

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Sharma

Baboota

Amin

et al. 2020

Pharmaceutical Biology

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“…The antioxidant properties of N. nucifera lotus leaves have been confirmed in their antioxidative stress by inhibiting LPO in hepatocyte cells [ 28 ]. In an in vitro study, a solution of 70% ethanol of N. nucifera flowers decreased malondialdehyde and maintained GSH and glutathione peroxidase to the normal level in isolated perfused rat kidneys that were induced by a Fenton mixture [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Nuchniyom,

Intui,

Laoung-on

et al. 2023

Toxics

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Mancozeb (Mz) is one of the most widely used pesticides that has been reported to cause adverse human health risks. White Nelumbo nucifera (N. nucifera) petals have therapeutic properties to prevent toxicity. Hence, this study attempted to determine the effects of N. nucifera extract on hepatotoxicity and oxidative stress in mancozeb-treated rats. Seventy-two male rats were divided into nine groups and designed with a control; N. nucifera extract was administered at the doses of 0.55, 1.1, and 2.2 mg/kg bw/day, Mz was administered at 500 mg/kg bw/day, and the co-treatment groups (N. nucifera and Mz) were administered 0.55, 1.1, and 2.2 mg/kg bw/day of N. nucifera followed by administering Mz 500 mg/kg bw/day daily for 30 days. The results showed that all doses of N. nucifera extract did not induce hepatic toxicity and could suppress the toxicity of mancozeb by increasing body weight gain and decreasing relative liver weight, lobular inflammation, and total injury score. The combination treatment also decreased the molecular markers of oxidative stress (2-hydroxybutyric acid, 4-hydroxynonenal, l-tyrosine, pentosidine, and N6-carboxymethyllysine). Furthermore, the reduced glutathione and oxidized glutathione contents were adjusted close to the normal level. Therefore, N. nucifera extract is a natural antioxidant supplement that could decrease the toxicity of mancozeb and can be safely consumed.

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“…Antioxidants block the free radicals formation by different ways and establish important control function in some oxidative stress diseases (Allison et al, 2001, Harbone, 1994 and in food conservation (Skerget et al, 2005). Then, new natural antioxidants, mainly those isolated from medicinal plants, acquire great pharmacological importance and the researches of this compounds have been developed too much in the last years (Capecka et al, 2005;Harish & Shivanandappa, 2006;Wu et al, 2006;Andrade et al, 2007;Castilhos et al, 2007;Souza et al, 2007;Vicentino & Menezes, 2007;Balestrin et al, 2008;Iha et al, 2008;Nunes et al, 2008;Fonseca et al, 2009;Krishnamoorthy et al, 2009;Morais et al, 2009;Rebelo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of Maytenus imbricata Mart., Celastraceae

Silva¹,

Silva²,

Barbosa³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Atividade antioxidante de Maytenus imbricata Mart., Celastraceae". A atividade antioxidante, poder redutor (RP) e a atividade coletora de radicais livres (FRS) usando 2,2-difenil-1-picrilhidrazil (DPPH), e a concentração de substâncias fenólicas totais dos extratos e substâncias isoladas das folhas, caules e raízes de Maytenus imbricata Mart. (Celastraceae) foram avaliados. Alguns extratos, a mistura de compostos fenólicos e epicatequina mostraram alto poder redutor e atividade antioxidante (DPPH) em comparação com o padrão butilhidroxianisol (BHA) e ácido gálhico (GA) utilizados no ensaio. O extrato acetato de etila das folhas mosraram alto teor de substâncias fenólicas e alto poder redutor e atividade antioxidante em relação aos outros extratos. Este fato indica haver alguma relação entre a concentração de substâncias fenólicas e o poder redutor. O solvente usado no processo de extração influencia a composição química dos extratos e, consequentemente, as atividades redutoras e antioxidantes.Unitermos: Atividade antioxidante, poder redutor, Maytenus imbricata, Celastraceae. ABSTRACT:The free radical scavenging activity (FRS) using 2,2-diphenyl-1-picrylhydrazyl (DPPH), the reducer power and the total phenolic concentration of extracts and compounds isolated from leaves, branches and roots of Maytenus imbricata Mart. (Celastraceae) were evaluated. Some extracts, a mixture of phenolic compounds (MPC) and epicatechin showed higher RP and FRS (DPPH) activities in comparison with the standard butylhydroxyanisole (BHA) and galic acid (GA) used in assays. The ethyl acetate extract from leaves showed higher total phenolic content and also higher RP and FRS (DPPH) than the other extracts. These facts indicate that there are some relations between phenolic concentration in the extract and the antioxidant activity and the reducer power. The solvent used in the extraction process influences the chemical composition of the extracts and consequently its antioxidant and reducer power activities.

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Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Cited by 5 publications

References 17 publications

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Ameliorative effect of a standardized polyherbal combination in methotrexate-induced nephrotoxicity in the rat

Effects of Nelumbo nucifera Gaertn. Petal Tea Extract on Hepatotoxicity and Oxidative Stress Induced by Mancozeb in Rat Model

Antioxidant activity of Maytenus imbricata Mart., Celastraceae

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