Antioxidant activity of phenolic acids and esters present in red wine on human Low-Density Lipoproteins

Urizzi, Pascale; Monje, Marie‐Carmen; Souchard, Jean‐Pierre; Abella, Annie; Chalas, Jacqueline; Lindenbaum, A; Vergnes, Laurent; Labidalle, Serge; Nepveu, Françoise

doi:10.1051/jcp:1999117

Cited by 22 publications

(12 citation statements)

References 6 publications

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“…Red wine antioxidants are constituted by several families of polyphenols with potential antioxidant capacities [7,10,12,[17][18][19][51][52][53][54]. However, there is no clarity regarding which type of compounds contribute most to the observed antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements

Hötzer

Henríquez

Pino

et al. 2005

Free Radical Research

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Cu(II) mediated low density lipoprotein (LDL) oxidation has been followed by the changes in absorbance at 234 nm and the emitted low level chemiluminescence (CL). The similarity of the time profiles allows us to conclude that the emitted CL is due to the decomposition of a transient product, most likely a hydroperoxide. Red wine, as well as its fractions, afford a noticeable protection when added prior to the start of the LDL oxidation process. On the other hand, when they are added after the onset of the autocatalytic oxidation phase, red wine and its fractions behave as pro-oxidants. This is particularly evidenced by a strong burst of CL (enhancement of the light by a factor approximately 20). This burst is reduced by metal chelators (EDTA and DFO) and can be associated to a sequence of reactions such as XOH + Cu(II) --> X* + H(+) + Cu(I), Cu(I) + LOOH --> chemiluminescence where XOH is a phenolic compound and LOOH is a peroxide-like compound produced in the LDL oxidation.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements

Hötzer

Henríquez

Pino

et al. 2005

Free Radical Research

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“…Moreover, the antioxidant activity of the esterified benzoic and hydroxycinnamic derivatives is higher than the corresponding acids on the lipoperoxidation of low-density lipoprotein [41]. Unfortunately, the extraction of the natural caffeic acid esters, such as CAPE, methyl caffeate, and CfE from propolis or plant sources requires large quantities of these expensive natural products.…”

Section: Isolation Of Cfementioning

confidence: 99%

Ethyl caffeate from Verdicchio wine: Chromatographic purification and in vivo evaluation of its antifibrotic activity

Boselli

Bendia

Lecce

et al. 2009

J of Separation Science

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Ethyl caffeate (CfE, caffeic acid ethyl ester) was extracted from dealcoholized Verdicchio, a white wine from Marche (Italy) with ethyl acetate and then purified with semipreparative reversed-phase high-performance liquid chromatography (RP-HPLC) using an ODS2 column (25 cm Â 20 mm id) at an isocratic flow of 5 mL/min (the mobile phase A was formic acid 4.5% in water and the mobile phase B was acetonitrile). The CfE extract administered intraperitoneally at 1 mmol/L in rats previously treated with 10 mg/kg dimethylnitrosamine was able to prevent the dimethylnitrosamine-induced loss in body and liver weight, as well as to reduce the degree of liver injury, as determined by alanine aminotransferase values and necroinflammatory score, after a 1-week treatment. This was associated with a reduced hepatic stellate cells activation (from 16.8 to 8.3% of smooth muscle actin positive parenchyma) and proliferation (from 11.3 to 5.5 cells/mm 2 ). The collagen synthesis was also reduced: the percentage of Sirius Red positive parenchyma decreased from 21.7 to 7.2%. The CfE levels of Verdicchio wine determined with RP-HPLC-DAD were about 14 times the active levels tested in the in vivo test. CfE can be considered as a promising natural compound for future application in chronic liver disease.

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“…24 In addition to this, being a strong natural antioxidant, it has arterioprotective properties. 25 The antitumoral activity of GA is mainly attributed to its character of inducing apoptosis. 26,27 Of special importance is that Qiu et al 28 found that GA could induce VSMC death, whereas GA was reported to show no cytotoxicity against normal ECs.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid Tailoring Surface Functionalities of Plasma-Polymerized Allylamine-Coated 316L SS to Selectively Direct Vascular Endothelial and Smooth Muscle Cell Fate for Enhanced Endothelialization

Yang¹,

Xiong²,

Qi³

et al. 2014

ACS Appl. Mater. Interfaces

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The creation of a platform for enhanced vascular endothelia cell (VEC) growth while suppressing vascular smooth muscle cell (VSMC) proliferation offers possibility for advanced coatings of vascular stents. Gallic acid (GA), a chemically unique phenolic acid with important biological functions, presents benefits to the cardiovascular disease therapy because of its superior antioxidant effect and a selectivity to support the growth of ECs more than SMCs. In this study, GA was explored to tailor such a multifunctional stent surface combined with plasma polymerization technique. On the basis of the chemical coupling reaction, GA was bound to an amine-group-rich plasma-polymerized allylamine (PPAam) coating. The GA-functionalized PPAam (GA-PPAam) surface created a favorable microenvironment to obtain high ECs and SMCs selectivity. The GA-PPAam coating showed remarkable enhancement in the adhesion, viability, proliferation, migration, and release of nitric oxide (NO) of human umbilical vein endothelial cells (HUVECs). The GA-PPAam coating also resulted in remarkable inhibition effect on human umbilical artery smooth muscle cell (HUASMC) adhesion and proliferation. These striking findings may provide a guide for designing the new generation of multifunctional vascular devices.

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Antioxidant activity of phenolic acids and esters present in red wine on human Low-Density Lipoproteins

Abstract: OATAO is an open access repository that collects the work of some Toulouse researchers and makes it freely available over the web where possible.

Cited by 22 publications

References 6 publications

Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements

Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements

Ethyl caffeate from Verdicchio wine: Chromatographic purification and in vivo evaluation of its antifibrotic activity

Gallic Acid Tailoring Surface Functionalities of Plasma-Polymerized Allylamine-Coated 316L SS to Selectively Direct Vascular Endothelial and Smooth Muscle Cell Fate for Enhanced Endothelialization

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