Antioxidant Activity of Piperazine Compounds: A Brief Review

Abstract

Piperazine ring is found in several potent antioxidant molecules. Literature survey revealed that the piperazine ring has been coupled to different heterocyclic rings such as quinoline, pyridine, pyrazine, azole, 1,3,4-oxadiazole, 1,4-benzodioxane, pyrrolidinone, benzimidazole, pyrazine benzimidazole to obtain compounds with good antioxidant activity. It is found that the natural compounds like α-lipoic acid, methylxanthine, berberine, sarsasapogenin, chrysin, chromen-4-one, co-enzyme Q when attached to piperazine ring, antioxidant activity was improved. In the present article, piperazine containing antioxidant molecules were reviewed.