Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics

Adomako-Bonsu, Amma G.; Chan, Shyue An; Pratten, Margaret K.; Fry, Jeffrey R.

doi:10.1016/j.tiv.2017.01.016

Cited by 146 publications

(82 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Again, rosmarinic acid and caffeoylquinic acids could be contributing to the functional property of the PEE. Antioxidant capacities of these phenolic compounds were repeatedly demonstrated in both in vitro and in vivo experiments (Zhang et al, 2015;Markovi c and To sovic, 2016;Adomako-Bonsu et al, 2017).…”

Section: Effect Of Chilto Pee On In Vitro Fat Absorptionmentioning

confidence: 92%

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Orqueda

Torres

Zampini

et al. 2020

Heliyon

View full text Add to dashboard Cite

A B S T R A C TThe "red chilto" (Solanum betaceum Cav) is a native fruit from the Yungas forest of Argentina. Red chilto is a neglected and underutilized native species (NUS). The objective of this work was to evaluate the potentiality of pulp, seed and skin from "red chilto" as a functional food ingredient to add value to a native resource of Argentine Yungas to promote sustainable integral use of it. The powders have low carbohydrate and sodium content and are a source of vitamin C, phenolic acids (rosmarinic acid and caffeoylquinic acid), anthocyanins, condensed tannins, carotenoids, potassium, and fiber. The phenolics of chilto powders showed, before and after simulated gastroduodenal digestion, antioxidant activity (ABTS þ ; H 2 O 2 ; O 2 ; HO ) and were able to inhibit enzymes related to metabolic syndrome, such as α-glucosidase, α-amylase and lipase. Chilto powder showed hypoglycemic effect by increasing glucose adsorption, decreasing glucose diffusion rate and by promoting glucose transport across the cell membrane. These results suggest the potential of Argentinean "red chilto" fruits as functional food ingredients or dietary supplements to prevent metabolic syndrome principally by its antioxidant, hypoglycemic and hypolipemic effects.

show abstract

Section: Effect Of Chilto Pee On In Vitro Fat Absorptionmentioning

confidence: 92%

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Orqueda

Torres

Zampini

et al. 2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…Likewise, the RA concentration in the whole plant was the highest at 0.5 dS•m −1 among all treatments. Moreover, the results of our study indicated that A. rugosa under low EC treatments exhibited a trend of an increasing RA concentration because RA is a phenylpropanoid with a very strong antioxidant capacity [33]. A group of genes that are involved in the biosynthetic pathway of RA consisting of phenylalanine ammonia-lyase: PAL, 4-coumarate: CoA ligase: 4CL, and cinnamate 4-hydroxylase: C4H, was strongly produced under nitrogen deficiency [34].…”

Section: Acacetin Tilianin and Rosmarinic Acid Concentrations And Cmentioning

confidence: 66%

Optimizing the Electrical Conductivity of a Nutrient Solution for Plant Growth and Bioactive Compounds of Agastache rugosa in a Plant Factory

2020

View full text Add to dashboard Cite

The objective of this study was to determine the proper electrical conductivity (EC) of a nutrient solution (NS) for accumulating bioactive compounds of Agastache rugosa without decreasing plant growth. Six-week-old seedlings were transplanted in a deep flow technique system with Hoagland NS with a 2.0 dS·m−1 EC for the initial week. From eight days after transplanting, the plants were treated with six EC treatments of 0.5, 1.0, 2.0, 4.0, 6.0, and 8.0 dS·m−1 for three weeks. Plant growth parameters, leaf gas exchange parameters, the relative chlorophyll value, and the ratio of variable to maximum fluorescence (Fv/Fm) were measured, and the rosmarinic acid (RA), tilianin, and acacetin concentrations were analyzed at 28 days after transplanting. The results showed that almost all plant growth parameters were maximized at 2.0 and 4.0 dS·m−1 and minimized at 8.0 dS·m−1 compared with the other EC treatments. The relative chlorophyll and Fv/Fm values were maximized at 2.0 and 4.0 dS·m−1. Similarly, leaf gas exchange parameters were increased at 2.0 and 4.0 dS·m−1. The RA content exhibited significantly higher values at 0.5, 1.0, 2.0, and 4.0 dS·m−1 compared with other treatments. The tilianin and acacetin contents exhibited the significantly highest values at 4.0 and 0.5 dS·m−1, respectively. These results suggest optimal EC treatment at 4.0 dS·m−1 for increasing bioactive compounds in A. rugosa plants without decreasing plant growth. Excessively high or low EC induced salinity stress or nutrient deficiency, respectively. Furthermore, among the plant organs, the roots of A. rugosa contained the highest RA concentration and the flowers contained the highest tilianin and acacetin concentrations, which revealed a higher utilization potential of the roots and flowers for bioactive compounds.

show abstract

“…Four phenolic acids were identified and quantified from EH: 4‐hydroxybenzoic acid, caffeic acid, p ‐coumaric acid, and rosmarinic acid (Table ). These compounds were reported to have antioxidant activities: 4‐hydroxybenzoic acid (Lewis, ), caffeic acid (Cartron, Carbonneau, Fouret, Descomps, & Leger, ), and rosmarinic acid (Adomako‐Bonsu, Chan, Pratten, & Fry, ). They were also reported to have antitumor activities: 4‐hydroxybenzoic acid (Seidel, Schnekenburger, Dicato, & Diederich, ) and p ‐coumaric acid (Jaganathan, Supriyanto, & Mandal, ; Janicke, Onning, & Oredsson, ).…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activities and HepG2 cells growth inhibitory capacity of whole plant ethanol extracts (Eclipta alba Hassk and Mesona procumbens Hemsl)

Lay

2017

J Food Biochem

View full text Add to dashboard Cite

This study investigated in vitro antioxidant and hepatocellular carcinoma (HepG2) cells growth inhibitory effect of Eclipta alba Hassk (EH) and Mesona procumbens Hemsl (MH). Extracts from ethanol 50% (E50) were chosen for the assays. Total phenolic and flavonoid content and the antioxidant activities including ABTS 1 and DPPH radical-scavenging system were determined. The identification of phenolic compounds was analyzed by high performance liquid chromatography (HPLC). It was found that higher levels of DPPH and ABTS 1 radical-scavenging activity were detected from the EH extract with IC 50 of 41.91 6 0.08 and 75.49 6 1.15 mg/mL, respectively. The rate of DPPH radical-scavenging activity was significantly influenced by the reaction time. The 4hydroxybenzoic acid, caffeic acid, p-coumaric acid, and rosmarinic acid were the identified compounds in the EH. The 7-hydroxycoumarin, ferulic acid, and rutin being new compounds and two known compounds were identified in the MH. Lactate dehydrogenase released in medium was also evaluated. Extracts of the EH and MH stimulated the apoptotic factors bcl-2, bax, caspase-3, caspase-9 in HepG2. Overall, the EH extract was higher in total phenolic and flavonoid content, antioxidant potential and more effective in inhibiting cancer cell growth.

show abstract

Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics

Cited by 146 publications

References 41 publications

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: effect of in vitro simulated gastroduodenal digestion

Optimizing the Electrical Conductivity of a Nutrient Solution for Plant Growth and Bioactive Compounds of Agastache rugosa in a Plant Factory

Antioxidant activities and HepG2 cells growth inhibitory capacity of whole plant ethanol extracts (Eclipta alba Hassk and Mesona procumbens Hemsl)

Contact Info

Product

Resources

About