Antioxidant Activity of Stevia Leaf Extracts Prepared by Various Extraction Methods

김재훈,; 성낙윤,; 권선규,; 정필문,; 최종일,; 윤요한,; 윤태영,; 기희진,; 이주운,

doi:10.3746/jkfn.2010.39.2.313

Cited by 15 publications

(4 citation statements)

References 15 publications

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“…The extract was comparatively devoid of big particles and equivalent in color to weak coffee or really strong tea. Then the extract was poured into large vessels and leaved to dry in open air for 3 days 19 .…”

Section: Stevia Extractmentioning

confidence: 99%

Stevia Extract and MK-801 Attenuate Nalbuphine Tolerance and Dependence in Mice: Role of Glutamate, Nitric Oxide, and Oxidative stress

Ali

2023

Sphinx Journal of Pharmaceutical and Medical Sciences

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This study aimed to investigate for the first time, the potential role of stevia aqueous extract alone and in combination with MK-801 on nalbuphine-induced tolerance and dependence in mice using biochemical and histological tools. In this study, Repeated administration of stevia extract (300 mg/kg, p.o) along with nalbuphine (10 mg/kg, s.c.) attenuated the development of tolerance, as measured by the hot plate test, and dependence, as assessed by naloxone (5 mg/kg, i.p.) -precipitated withdrawal manifestations. Concomitantly, increase in brain glutamate level, malondialdehyde level, and serum nitrite level-induced by repeated administration of nalbuphine to mice or by administration of naloxone to nalbuphine-dependent mice were inhibited by co-administration of stevia extract. Also, co-administration of the stevia extract inhibited the decrease in brain intracellular reduced glutathione level and glutathione peroxidase activity induced by both treatments. The inhibitory effect of the extract on nalbuphine-induced tolerance and dependence and on naloxone-induced biochemical alterations in nalbuphine-dependent mice was enhanced by concurrent i.p. administration of the NMDA receptor antagonist, MK-801 (0.25 mg/kg). histopathological results revealed that stevia extract coadministration produced decrease in nerve cell degeneration, vacuolation, apoptosis and enhance neuropil appearance. This histopathological improvement increased by concurrent administration of MK-801 with stevia extract. These results provide evidence that stevia extract appears to have a therapeutic potential in opioid tolerance and dependence, through inhibition of nalbuphine-induced elevation in glutamate level, NO overproduction and oxidative stress.

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Section: Stevia Extractmentioning

confidence: 99%

Stevia Extract and MK-801 Attenuate Nalbuphine Tolerance and Dependence in Mice: Role of Glutamate, Nitric Oxide, and Oxidative stress

Ali

2023

Sphinx Journal of Pharmaceutical and Medical Sciences

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“…2). Kim et al (2010) reported that VE is efficient for the extraction of antioxidants in stevia, although the content of steviol glycosides are not represented. Therefore, despite VE method was suitable for antioxidants extraction, it had some weakness of low extraction efficiency of sweetness components and it requires much equipment.…”

Section: Analysis Of Sweetness Components According To Extraction Metmentioning

confidence: 99%

“…Stevia extract method were conducted by some researchers (Lim and Oh, 2004;Kim et al, 2010;Afandi et al, 2013;Periche et al, 2015). Periche et al (2015) reported that the greatest yield of steviol glycosides was obtained with microwave treatment, but the conventional high temperature method (90 o C, 1min) was the most suitable for antioxidant extraction.…”

Section: Introductionmentioning

confidence: 99%

“…Periche et al (2015) reported that the greatest yield of steviol glycosides was obtained with microwave treatment, but the conventional high temperature method (90 o C, 1min) was the most suitable for antioxidant extraction. In addition, Kim et al (2010) reported that vacuum extraction was proper for higher antioxidant activity. Afandi et al (2013) reported that methanol is the best solvent for the extraction of rebaudidoside A.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Sweetness Components by Harvest Times and Extract Methods in Stevia

Kim

Rho

2019

JAS

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Antioxidative and antimicrobial activities of Oenothera biennisextracted by different methods

Kim¹,

Lee²

2016

Korean Journal of Food Preservation

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A effect of extraction methods, including stirrer extraction method (SE), ultrasonification extraction method (USE), reflux extraction method (RE), autoclave extraction (AE) and low temperature high pressure extraction (LE) method on the antioxidative and antimicrobial activities of ethanol extracts of Oenothera biennis was investigated. The extraction yield (46.33%), total polyphenol (463.05 mg GAE/g) and flavonoid (71.71 mg RHE/g) content of Oenothera biennis extract obtained by RE were higher than those from other extraction methods. The antimicrobial activity of Oenothera biennis extract was only observed against Bacillus cereus among other tested organisms (Bacillus cereus, Staphylococcus aureus, Escherichia coli and Salmonella Typhimurium). Oenothera biennis obtained by RE showed the best DPPH radical scavenging ability (74.40%), ABTS radical scavenging ability (65.29%), reducing power (1.370 (OD700)) and ferrous ion chelating ability (90.14%) compared with other tested extraction methods tested. The RE method was the most efficient method for extracting crude antioxidant and antimicrobial substances from Oenothera biennis. These results suggested that Oenothera biennis obtained by RE could be used as a bioactive and functional material in the food industry.

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Antioxidant Activity of Stevia Leaf Extracts Prepared by Various Extraction Methods

Cited by 15 publications

References 15 publications

Stevia Extract and MK-801 Attenuate Nalbuphine Tolerance and Dependence in Mice: Role of Glutamate, Nitric Oxide, and Oxidative stress

Stevia Extract and MK-801 Attenuate Nalbuphine Tolerance and Dependence in Mice: Role of Glutamate, Nitric Oxide, and Oxidative stress

Analysis of Sweetness Components by Harvest Times and Extract Methods in Stevia

Antioxidative and antimicrobial activities of Oenothera biennisextracted by different methods

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