Antioxidant activity of tertiary amines with 2,6-di-tert-butylphenol and pyridine moieties

Половинкина, М. А.; Osipova, A. D.; Осипова, В. П.; Берберова, Н. Т.; Nikitin, Evgeny A.; Shpakovsky, D. B.; Милаева, Е. Р.

doi:10.1063/5.0069278

Cited by 3 publications

(2 citation statements)

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“…At present, it is in the phase II clinical trials for the treatment of invasive candidiasis, candidemia and invasive aspergillosis. [11] Pyridine and its derivatives are very important class of compounds with a wide-spectrum of biological activities, including antimicrobial, [12][13][14][15][16][17] antiviral, [18][19][20][21] antitumor, [22][23][24][25] and antioxidant [26][27][28][29][30][31] activities. Radwan et al [32] synthesized a series of new pyridine compounds and tested their antibacterial activity, among which the antibacterial activity of compound 6 was higher than that of other compounds.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Antimicrobial Activity Evaluation of Pyridine Derivatives Containing Imidazo[2,1‐b][1,3,4]Thiadiazole Moiety

Yang,

Jiao,

Quan

et al. 2024

Chemistry & Biodiversity

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Four series of novel pyridine derivatives (17a–i, 18a–i, 19a–e, and 20a–e) were synthesized and their antimicrobial activities were evaluated. Of all the target compounds, almost half target compounds showed moderate or high antibacterial activity. The 4‐F substituted compound 17d (MIC = 0.5 µg/mL) showed the highest antibacterial activity, its activity was twice the positive control compound gatifloxacin (MIC = 1.0 µg/mL). For fungus ATCC 9763, the activities of compounds 17a and 17d are equivalent to the positive control compound fluconazole (MIC = 8 µg/mL). Furthermore, compounds 17a and 17d showed little cytotoxicity to human LO2 cells, and did not show hemolysis even at ultra‐high concentration (200 μM). The results indicate that these compounds are valuable for further development as antibacterial and antifungal agents.

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Section: Introductionmentioning

confidence: 99%

“…Pyridine and its derivatives are very important class of compounds with a wide‐spectrum of biological activities, including antimicrobial, [12–17] antiviral, [18–21] antitumor, [22–25] and antioxidant [26–31] activities. Radwan et al [32] .…”

Section: Introductionmentioning

confidence: 99%