Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin

Ferreira, Fabricia da Rocha; Valentim, Iara Barros; Ramones, Edgar Luís Catarí; Trevisan, M.; Olea‐Azar, Claudio; Pérez-Cruz, Fernanda; Abreu, Fabiane Caxico de; Goulart, Marília Oliveira Fonseca

doi:10.1016/j.lwt.2012.09.032

Cited by 57 publications

(31 citation statements)

References 27 publications

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“…As a first approach, the free radical-scavenging ability of phenolic compounds can be assessed by monitoring the reduction of the stable colored DPPH radical in MeOH. As β-CD is insoluble in MeOH, a 1:1 MeOH -water mixture was used (Ferreira et al, 2013). Table 2 shows the radical-scavenging percentage values and the stoichiometry n of HT samples (n = number of DPPH radicals reduced per HT molecule).…”

Section: Hydrogen Abstraction By Dpphmentioning

confidence: 99%

Characterization of hydroxytyrosol-β-cyclodextrin complexes in solution and in the solid state, a potential bioactive ingredient

Malapert

Reboul

Tourbin

et al. 2019

LWT

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This study focused for the first time on characterizing the inclusion complexes between β-cyclodextrin (β-CD) and hydroxytyrosol (HT) in the solid state. In solution, HT and β-CD are able to form a 1:1 inclusion complex with an association constant of 33.2 ± 3.7 M-1. In the solid state, the inclusion complexes prepared by freezedrying and spray-drying of an equimolar mixture of both partners were characterized and compared by 13 C NMR and SEM. After dissolution, their free radical-scavenging ability was also determined by UV-visible spectroscopy. The results show that β-CD and drying processes have no effect on the efficiency of HT to reduce the DPPH radical. The solid state 13 C NMR data provided information on the spatial proximity between β-CD and HT and suggest the formation of inclusion complexes for both drying processes compared to the physical mix. However, the morphology of the solids obtained was significantly different, as spherical particles were formed by spraydrying while freeze-drying only provided irregular shapes.

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Section: Hydrogen Abstraction By Dpphmentioning

confidence: 99%

Characterization of hydroxytyrosol-β-cyclodextrin complexes in solution and in the solid state, a potential bioactive ingredient

Malapert

Reboul

Tourbin

et al. 2019

LWT

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“…Thus, it is important to evaluate this protective effect through a specific test (Ferreira et al. 2013 ).…”

Section: Resultsmentioning

confidence: 99%

Polyphenol profile by UHPLC-MS/MS, anti-glycation, antioxidant and cytotoxic activities of several samples of propolis from the northeastern semi-arid region of Brazil

Xavier

Valentim

Camatari

et al. 2017

Pharmaceutical Biology

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Context: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil – sample A from Ribeira do Pombal and B, from Tucano – were investigated, with new information regarding their biological activities. Objective: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. Material and methods: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH•, FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0.04–25 μg/mL concentrations, for 72 h. The determination of primary phenols by ultra high-pressure liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) and volatile organic compounds content by gas chromatography-mass spectrometry (GC-MS) were also performed. Results: The EEP polar fractions exhibited up to 90% protection against lipid peroxidation. The IC50 value for anti-glycation activity of EEP was between 16.5 and 19.2 μg/mL, close to aminoguanidine (IC50 = 7.7 μg/mL). The use of UHPLC-MS/MS and GC-MS allowed the identification of 12 bioactive phenols in the EEP and 24 volatile compounds, all already reported. Conclusions: The samples present good antioxidant/anti-glycation/cytotoxic activities and a plethora of biologically active compounds. These results suggest a potential role of propolis in targeting ageing and diseases associated with oxidative and carbonylic stress, aggregating value to them.

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“…4c). 51 While toluene exhibited characteristic bands at 3026 cm À1 (C-H stretching in aromatic ring), 1492 cm À1 (C-C stretching in aromatic ring) and 722 cm À1 (out of plane C-H bending) ( Fig. 4d).…”

Section: Adsorption Of Volatile Organic Compoundsmentioning

confidence: 97%

Starch-based and multi-purpose nanofibrous membrane for high efficiency nanofiltration

et al. 2017

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Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin

Cited by 57 publications

References 27 publications

Characterization of hydroxytyrosol-β-cyclodextrin complexes in solution and in the solid state, a potential bioactive ingredient

Characterization of hydroxytyrosol-β-cyclodextrin complexes in solution and in the solid state, a potential bioactive ingredient

Polyphenol profile by UHPLC-MS/MS, anti-glycation, antioxidant and cytotoxic activities of several samples of propolis from the northeastern semi-arid region of Brazil

Starch-based and multi-purpose nanofibrous membrane for high efficiency nanofiltration

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