Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line

Aksoy, Özge Kılınçarslan; Mammadov, Ramazan; Seçme, Mücahit

doi:10.1007/s11033-020-05833-5

Cited by 6 publications

(11 citation statements)

References 33 publications

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“…As a housekeeping gene, beta-actin was employed to standardize the PCR results. Primers with the same sequences as those found in Kilincarslan Aksoy et al 38 and Sirin et al 39 were employed, and the sequences of these primers can be found in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Nanoarchitectonics of the Effects of Curcumin Carbon Dot-Decorated Chitosan Nanoparticles on Proliferation and Apoptosis-Related Gene Expressions in HepG2 Hepatocellular Carcinoma Cells

Ilhan

2023

ACS Omega

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This study examines the potential anticancer properties of curcumin carbon nanodot-decorated chitosan nanoparticles (CCM@CD/CS-NP) in HepG2 hepatocellular carcinoma cells. CCM@CD/CS-NPs were synthesized, and their size, morphology, and elemental analysis were characterized. The combination of curcumin carbon dots and chitosan in the form of a nanoparticle has a number of benefits, including improved solubility and bioavailability of curcumin, enhanced stability and biocompatibility of carbon dots, and sustained release of the drug due to the mucoadhesive properties of chitosan. The purpose of this research was to examine the efficacy of curcumin carbon dot-decorated chitosan nanoparticles as an anticancer agent in the treatment of HepG2 cell lines. The cell proliferation and apoptosis-related gene expressions in HepG2 cells were assessed to investigate the potential use of nanoparticles in vitro. The IC50 value for the inhibitory effect of CCM@CD/CS-NPs on cell growth and proliferation was determined to be 323.61 μg/mL at 24 h and 267.73 μg/mL at 48 h. Increased caspase-3 and -9 activation shows that CCM@CD/CS-NPs promoted apoptosis in HepG2 cells. It was also shown that the overexpression of Bax and the downregulation of Bcl-2 were responsible for the apoptotic impact of CCM@CD/CS-NPs. The nanoparticles have been shown to have minimal toxicity to normal liver cells, indicating their potential as a safe and effective treatment for HepG2. These novel nanomaterials effectively suppressed tumor development and boosted the rate of apoptotic cell death.

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Section: Methodsmentioning

confidence: 99%

Nanoarchitectonics of the Effects of Curcumin Carbon Dot-Decorated Chitosan Nanoparticles on Proliferation and Apoptosis-Related Gene Expressions in HepG2 Hepatocellular Carcinoma Cells

Ilhan

2023

ACS Omega

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“…Other solvents used were acetone (n = 1), n-butanol (n = 1), and mixtures, water/diethyl ether/ethyl acetate (n = 1) and diethyl ether/ethanol/water (n = 1). Among the conventional extraction techniques, maceration extraction [14,19,21,34,47], decoction technique [15], digestion technique [8][9][10]40,47], exhaustive serial extraction [15], soxhlet extraction [33], and reflux extraction were used [17,18,51].…”

Section: Sample Preparation and Phenolic Compound Extractionmentioning

confidence: 99%

“…In the case of phenolic acids, the number of representatives identified was higher when alcoholic solvents were used, than when the extraction solvent used was water. Thus, the extraction in methanol led to the identification of 11 phenolic acids by each of the two research teams led by Kılınçarslan Aksoy et al [10,40]; the ethanolic extracts allowed the identification of 11 [14] and, respectively, 14 phenolic acids [21], while only 4 [18] and, respectively, 5 representatives [43] were identified in the aqueous extracts. The lowest extraction efficiency was observed when the solvents used were ethyl acetate [16] and, respectively, a mixture of solvents, water/diethyl ether/ethyl acetate [17], which led to the identification of only two phenolic acids.…”

Section: Sample Preparation and Phenolic Compound Extractionmentioning

confidence: 99%

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Banc,

Rusu,

Filip

et al. 2023

Plants

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Quercus species have been widely used in traditional medicine, and recently, researchers’ attention has focused on galls of the genus Quercus as a source of health-promoting phytochemicals. This review presents a summary of the most recent findings on the phytochemistry and bioactivity of oak galls, following the screening of scientific papers published in two relevant databases, PubMed and Embase, between January 2018 and June 2023. The oak galls are rich in active compounds, mostly gallotannins and phenolic acids. Due to these secondary metabolites, the reviewed studies have demonstrated a wide range of biological activities, including antioxidant and anti-inflammatory actions, antimicrobial properties, tissue-protective effects, and antitumor, anti-aging, and hypoglycemic potential. Thus, oak galls are a promising natural matrix, to be considered in obtaining pharmaceutical and cosmetic preparations used in anti-aging strategies and, together with medications, in the management of age-related diseases. In further evaluations, the valuable functional properties of oak galls, reported mostly in preclinical studies, should be confirmed with clinical studies that would also take into account the potential health risks of their use.

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“…Tannic acid (TA), an antioxidant extracted from oak apple, has been proven to realize stable rGO suspensions in water and organic solvents but resulted in a low conductivity. [ 119,120 ]…”

Section: Ink Selectionmentioning

confidence: 99%

Biopolymer Composites Material Extrusion and their Applications: A Review

Li,

Yang,

Elias

et al. 2023

Adv Eng Mater

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Advances in additive manufacturing are leading to the emergence of new printable applications, including sensors for healthcare monitoring and bioengineering scaffolds. Research is driven by designing new printable inks including composites that can be extruded and respond to changes in their surroundings and patterning these materials on the microscale. In modern printing techniques, an emerging modified three‐dimensional (3D) printing method: materials extrusion has been utilized for customizable electronics because of its high compatibility with various inks, low cost, and versatility to different levels of complexity. Material extrusion enables not only the printing of 2D and 3D architecture of the electrode structure but also the bioprinting of structures such as conductive scaffolds. In this review, fundamental insights into rational printable ink formulation including colloidal suspensions, gels, polymer melts, composites, printing criteria, processes, and applications toward printable electronics using composites composed of nanomaterials and biopolymers are fully discussed. New manufacturing insights on how to further improve the resolution and simplify the printing process of responsive materials are discussed, which have not been seen in currently published representative reviews. It is envisioned that this review provides high scientific merits to readers working in wearable devices, biological smart materials, and flexible nanoelectronics.

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Antioxidant activity, phytochemical composition of Andricus tomentosus and its antiproliferative effect on Mia-Paca2 cell line

Cited by 6 publications

References 33 publications

Nanoarchitectonics of the Effects of Curcumin Carbon Dot-Decorated Chitosan Nanoparticles on Proliferation and Apoptosis-Related Gene Expressions in HepG2 Hepatocellular Carcinoma Cells

Nanoarchitectonics of the Effects of Curcumin Carbon Dot-Decorated Chitosan Nanoparticles on Proliferation and Apoptosis-Related Gene Expressions in HepG2 Hepatocellular Carcinoma Cells

Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years

Biopolymer Composites Material Extrusion and their Applications: A Review

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