Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Deng, Jeng-Shyan; Chi, Chuan-Sung; Huang, Shyh-Shyun; Shie, Pei-Hsin; Lin, Tsung-Hui; Huang, Guan‐Jhong

doi:10.1016/j.jep.2011.07.041

Cited by 67 publications

(44 citation statements)

References 24 publications

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“…It is a body defence response in order to eliminate or limit the spread of injurious agent. However, excessive inflammation leads to several acute and chronic human diseases (Deng et al, 2011;Kaushik et al, 2012;Ambedkar et al, 2012). Carrageenan-induced rat paw edema model is a suitable model for determining anti-inflammatory property.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Prashith¹,

R²,

Raghavendra³

2013

Sci. Technol. Arts Res. J.

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In the present study, pharmacological activities antipyretic and CNS depressant activity of crude extract of isolated from Western Ghats soil of Agumbe, Karnataka, India have been studied. T isolate PO-178 was grown in starch casein nitrate broth medium. The culture filtrate was condensed to obtain crude extract. Anti-inflammatory, analgesic, antipyretic and CNS depressant activities of the crude extract were determined by Carrageenan edema, tail flick, yeast induced pyrexia and s The extract exhibited dose dependent anti depressant activity, however, the activities observed were lesser than st Further studies are under progress to recover pharmacologically active principles from the extract of Streptomyces species PO-178 and to determine their activities.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Prashith¹,

R²,

Raghavendra³

2013

Sci. Technol. Arts Res. J.

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“…In nature, macrophage plays an important role in response to inflammation via the release of several pro-inflammatory mediators including nitric oxide (NO), prostaglandinE 2 (PGE 2 ) and proinflammatory cytokines (IL-6, TNF-a, IL-1b). These mediators are also produced in many inflamed tissues, enhancing the inflammation-regulatory transcription factors of their mRNAs via the nuclear factor NF-jB pathway [7,8]. Based on this evidence, it is expected that if these substances can exhibit anti-inflammatory activity, they might also provide antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

“…Based on this evidence, it is expected that if these substances can exhibit anti-inflammatory activity, they might also provide antioxidant activity. Recent studies have been performed observing antioxidant and anti-inflammatory activities on substances extracted from plants [7,9]; there is limited information on substances extracted from animals.…”

Section: Introductionmentioning

confidence: 99%

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An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

et al. 2014

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Antioxidant and anti-inflammatory activities were found from Crocodylus siamensis (C. siamensis) blood. The 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, nitric oxide scavenging, hydroxyl radical scavenging and linoleic peroxidation assays were used to investigate the antioxidant activities of the crocodile blood. Results show that crocodile blood components had antioxidant activity, especially hemoglobin (40.58 % nitric oxide radical inhibition), crude leukocyte extract (78 % linoleic peroxidation inhibition) and plasma (57.27 % hydroxyl radical inhibition). Additionally, the anti-inflammatory activity of the crocodile blood was studied using murine macrophage (RAW 264.7) as a model. The results show that hemoglobin, crude leukocyte extract and plasma were not toxic to RAW 264.7 cells. Also they showed anti-inflammatory activity by reduced nitric oxide (NO) and interleukin 6 (IL-6) productions from lipopolysaccharide (LPS)-stimulated cells. The NO inhibition percentages of hemoglobin, crude leukocyte extract and plasma were 31.9, 48.24 and 44.27 %, respectively. However, only crude leukocyte extract could inhibit IL-6 production. So, the results of this research directly indicate that hemoglobin, crude leukocyte extract and plasma of C. siamensis blood provide both antioxidant and anti-inflammatory activities, which could be used as a supplementary agent in pharmaceutical products.

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“…There is abundant literature regarding medicinal plants establishing a relation between anti-inflammatory and analgesic activities and their phenol/flavonoid content (Deliorman et al, 2007;Saeed et al, 2010;Deng et al, 2011). From the results of our pharmacological study that showed higher activity for the de-fatted ethanol extracts and the reported literature linking these effects to the flavonoidal and phenolic contents, the authors were interested in identifying these content.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and biological activities of Pouteria campechiana (Kunth) Baehni

El-Sayed¹,

El-Tanbouly²,

Moustafa³

et al. 2016

J. Med. Plants Res.

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The present study was conducted to evaluate the analgesic, anti-inflammatory and gastroprotective activities of ethanol, de-fatted ethanol extracts and n-hexane fractions of Pouteria campechiana (Kunth) Baehni leaves and seeds. Further chemical analysis was done to isolate and identify its bioactive compounds. The seeds ethanolic extract produced 85% inhibition of inflammation in the rat paw oedema test at the dose of 100 mg/kg after 4 h (p<0.05). On the other hand, the leaves ethanolic extract (200 mg/kg) exhibited maximum analgesic activity after 90 min (p<0.05) in the hot plate test. Both leaves and seeds ethanolic extracts showed significant decreases in gastric ulcer number and severity (p<0.05). Phytochemical investigation of P. campechiana leaves and seeds yielded six compounds: protocatechuic acid (C 1 ), gallic acid (C 2 ), quercetin (C 3 ), myricetin (C 4 ), myricetin-3-O-α-L-rhamnoside (C 5 ) and myricetin-3-O-β-galactoside (C 6 ). The study supports the use of P. campechiana in traditional medicine for conditions associated with inflammation, pain and peptic ulcers.

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Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola

Cited by 67 publications

References 24 publications

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

Pharmacological Activities of Streptomyces Species PO-178 Isolated from Rhizosphere Soil of Agumbe, Karnataka, India

An Investigation of Antioxidant and Anti-inflammatory Activities from Blood Components of Crocodile (Crocodylus siamensis)

Chemical composition and biological activities of Pouteria campechiana (Kunth) Baehni

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