Antioxidant and anti-adipogenic activities of the nuts of Castanopsis cuspidata var. thunbergii

Youn, Un-Young; Kim, Ryeong-Hyeon; Kim, Gyo-Nam; Lee, Seung‐Cheol

doi:10.1007/s10068-017-0183-2

Cited by 7 publications

(3 citation statements)

References 32 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, the IC 50 value of 80% ethanol extracts of CSL was 16.26 μg/mL [ 25 ], similar to that of the present study. Youn et al measured the antioxidant activities of a methanol extract of the nuts of CS at a concentration of 50 μg/mL [ 21 ]. DPPH and ABTS activities were 75% and 98%, respectively, with very high antioxidant activities at low concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…It is known to have antioxidant activity and reduce oxidative stress by decreasing intracellular ROS levels. In addition, CS has high 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activities [ 21 ]. Its radical scavenging capability prevents lipid peroxidation, cellular DNA damage, and, consequently, apoptosis in lung fibroblasts V79-4 cells treated with H 2 O 2 [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective Effect of Castanopsis sieboldii Extract against UVB-Induced Photodamage in Keratinocytes

et al. 2023

View full text Add to dashboard Cite

Ultraviolet B (UVB) rays disrupt the skin by causing photodamage via processes such as reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, DNA damage, and/or collagen degradation. Castanopsis sieboldii is an evergreen tree native to the southern Korean peninsula. Although it is known to have antioxidant and anti-inflammatory effects, its protective effect against photodamage in keratinocytes has not been investigated. Thus, in the present study, we investigated the effect of 70% ethanol extract of C. sieboldii leaf (CSL3) on UVB-mediated skin injuries and elucidated the underlying molecular mechanisms. CSL3 treatment restored the cell viability decreased by UVB irradiation. Moreover, CSL3 significantly inhibited UVB- or tert-butyl hydroperoxide-mediated ROS generation in HaCaT cells. ER stress was inhibited, whereas autophagy was upregulated by CSL3 treatment against UVB irradiation. Additionally, CSL3 increased collagen accumulation and cell migration, which were decreased by UVB exposure. Notably, epigallocatechin gallate, the major component of CSL3, improved the cell viability decreased by UVB irradiation through regulation of ER stress and autophagy. Conclusively, CSL3 may represent a promising therapeutic candidate for the treatment of UVB-induced skin damage.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Castanopsis sieboldii Extract against UVB-Induced Photodamage in Keratinocytes

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Hence, reducing the amount of lipids stored in adipocytes is momentous for obesity preventing and treating. Several natural plant extracts and their active ingredients are found to be influential in inhibiting adipogenesis [24] . Some of the latest investigations have indicated the anti-adipogenic roles of natural plants, including Coptidis rhizoma (berberine), green tea (catechin), and red pepper The negative (Con -) and positive (Con + ) controls were preadipocytes treated with 0.1% DMSO.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Anti-Obesity Compound with Inhibiting Properties on the Lipid Accumulation in 3T3-L1 Adipocytes

Payab

Hasani‐Ranjbar

Baeeri

et al. 2020

ibj

View full text Add to dashboard Cite

Background: Obesity as a developing global challenge can be characterized by increase in adipocyte number and size arising from adipogenesis. Control of adipogenesis, as a potential strategy, can prevent and manage obesity. So far, the effectiveness of herbal medicine and active ingredients therapies for obesity and metabolic syndrome treatment has been investigated. In this study, a novel combination of berberine, catechin, and capsaicin was developed, and their effect on 3T3-L1 adipocytes was investigated. Methods: The effect of active ingredient on the cell viability was assessed by MTT assay. Adipocytes were treated with various concentrations of berberine (3 and 6.25 μM), catechin (6.25 and 12.5 μM), and capsaicin (6.25 and 12.5 μM) alone and in combination. Results: All active ingredients did not affect the cell viability by MTT assay at different concentrations. The dual and triple combinations of three active ingredients showed excellent potential as anti-obese without any toxicity. The inhibitory effect of berberine, catechin, and capsaicin on the differentiation of 3T3-L1 preadipocytes was found to be dose-dependent. These results indicate that catechin in both doses may have a stronger effect than the two other active ingredients on the intracellular lipid accumulation. Also, the triple combination of the aforementioned ingredients showed better responses than their dual combination. Conclusion: This work is the first report to simultaneously investigate these three active ingredients in a single, dual, and triple formats. The berberine, catechin, and capsaicin co-treatment inhibits the adipogenesis during the differentiation process. This compound can be a prospective therapy for obesity and relevant diseases such as dyslipidemia.

show abstract

Exercise‐Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism

Al‐Ibraheem,

Hameed,

Marsool

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

BackgroundObesity poses a significant global health challenge, necessitating effective prevention and treatment strategies. Exercise and diet are recognized as pivotal interventions in combating obesity. This study reviews the literature concerning the impact of exercise‐induced cytokines, dietary factors, and inflammation on adipose tissue metabolism, shedding light on potential pathways for therapeutic intervention.MethodologyA comprehensive review of relevant literature was conducted to elucidate the role of exercise‐induced cytokines, including interleukin‐6 (IL‐6), interleukin‐15 (IL‐15), brain‐derived neurotrophic factor (BDNF), irisin, myostatin, fibroblast growth factor 21 (FGF21), follistatin (FST), and angiopoietin‐like 4 (ANGPTL4), in adipose tissue metabolism. Various databases were systematically searched using predefined search terms to identify relevant studies. Articles selected for inclusion underwent thorough analysis to extract pertinent data on the mechanisms underlying the influence of these cytokines on adipose tissue metabolism.Results and DiscussionExercise‐induced cytokines exert profound effects on adipose tissue metabolism, influencing energy expenditure (EE), thermogenesis, fat loss, and adipogenesis. For instance, IL‐6 activates AMP‐activated protein kinase (AMPK), promoting fatty acid oxidation and reducing lipogenesis. IL‐15 upregulates peroxisome proliferator‐activated receptor delta (PPARδ), stimulating fatty acid catabolism and suppressing lipogenesis. BDNF enhances AMPK‐dependent fat oxidation, while irisin induces the browning of white adipose tissue (WAT), augmenting thermogenesis. Moreover, myostatin, FGF21, FST, and ANGPTL4 each play distinct roles in modulating adipose tissue metabolism, impacting factors such as fatty acid oxidation, adipogenesis, and lipid uptake. The elucidation of these pathways offers valuable insights into the complex interplay between exercise, cytokines, and adipose tissue metabolism, thereby informing the development of targeted obesity management strategies.ConclusionUnderstanding the mechanisms by which exercise‐induced cytokines regulate adipose tissue metabolism is critical for devising effective obesity prevention and treatment modalities. Harnessing the therapeutic potential of exercise‐induced cytokines, in conjunction with dietary interventions, holds promise for mitigating the global burden of obesity. Further research is warranted to delineate the precise mechanisms underlying the interactions between exercise, cytokines, and adipose tissue metabolism.

show abstract

Antioxidant and anti-adipogenic activities of the nuts of Castanopsis cuspidata var. thunbergii

Cited by 7 publications

References 32 publications

Protective Effect of Castanopsis sieboldii Extract against UVB-Induced Photodamage in Keratinocytes

Protective Effect of Castanopsis sieboldii Extract against UVB-Induced Photodamage in Keratinocytes

Development of a Novel Anti-Obesity Compound with Inhibiting Properties on the Lipid Accumulation in 3T3-L1 Adipocytes

Exercise‐Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism

Contact Info

Product

Resources

About