Antioxidant and anti-collagenase activity of Hypericum hircinum L.

Mandrone, Manuela; Lorenzi, Beatrice; Venditti, Alessandro; Guarcini, Laura; Bianco, Armandodoriano; Sanna, Cinzia; Ballero, Mauro; Poli, Ferruccio; Antognoni, Fabiana

doi:10.1016/j.indcrop.2015.07.012

Cited by 54 publications

(37 citation statements)

References 36 publications

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“…For both these reasons, the wide variety of secondary metabolites and their bioactivities, the studies about the phytochemistry of this species are currently in the limelight. In this article, we report the phytochemical analysis of a sample of D. oleoides collected from a spontaneous population growing in Sardinia Island to verify if the isolated environment may have favored the development of a peculiar secondary metabolites pattern, as we already evidenced in other species growing in restricted areas and, in particular, in Sardinian territory . In fact, Sardinia, according to ‘Conservation International’ is part of the ten ‘mini‐Hotspots’ recognizable in the Mediterranean basin.…”

Section: Introductionmentioning

confidence: 89%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8, and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses. The identification of these compounds gives an experimental evidence of the variability in the secondary metabolites pattern owned by populations growing in restricted area in respect to populations not confined by geographical barrier.

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Section: Introductionmentioning

confidence: 89%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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“…In traditional use, several Hypericum species share the same utilizations, and ethnobotanical sources ascribe well‐defined therapeutic actions to almost all of them. For example, significant antioxidant, antifungal and antiviral actions not only are indicated for H. perforatum , but also for H. androsaemum , H. calycinum , H. hircinum , H. tetrapterum , and H. triquetrifolium . An effective radical‐scavenging activity, probably consequent to the antioxidant activity demonstrated by many in vitro experiments, is claimed for H. hircinum .…”

Section: Introductionmentioning

confidence: 99%

Variability of Hypericins and Hyperforin inHypericumSpecies from the Sicilian Flora

Lazzara¹,

Carrubba

Napoli

2020

Chemistry & Biodiversity

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Within Sicilian flora, the genus Hypericum (Guttiferae) includes 10 native species, the most popular of which is H. perforatum. Hypericum's most investigated active compounds belong to naphtodianthrones (hypericin, pseudohypericin) and phloroglucinols (hyperforin, adhyperforin), and the commercial value of the drug is graded according to its total hypericin content. Ethnobotanical sources attribute the therapeutic properties recognized for H. perforatum, also to other Hypericum species. However, their smaller distribution inside the territory suggests that an industrial use of such species, when collected from the wild, would result in an unacceptable depletion of their natural stands. This study investigated about the potential pharmacological properties of 48 accessions from six native species of Hypericum, including H. perforatum and five 'minor' species, also comparing, when possible, wild and cultivated sources. The variability in the content of active metabolites was remarkably high, and the differences within the species were often comparable to the differences among species. No difference was enlightened between wild and cultivated plants. A carefully planned cultivation of Hypericum seems the best option to achieve high and steady biomass yields, but there is a need for phytochemical studies, aimed to identify for multiplication the genotypes with the highest content of the active metabolites.

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“…Some compounds such as xanthones (Utami et al, 2017), gallic acid, β-carotten, catechin (Mukherjee et al, 2011), Eugenol, Hesperidin (Widowati et al, 2018), myricetin (Mukherjee et al, 2011), rutin, quecertin (Rusmana et al, 2017), Coumaric acid, vanillin (Widowati et al, 2016) have antioxidant and antiprotease (anti-collagenase, anti-hyaluronidase, anti-elastase, and anti-tyrosinase). Crude extract from plant also has antioxidant and antiprotease activity such as tea extract (Thring et al, 2009;Widowati et al, 2015), rose flowers extract (Thring et al, 2009), cocoa pod extract (Abdul Karim et al, 2014), Hypericum hircinum L extract (Mandrone et al, 2015), etc.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antioxidant and Anti-collagenase Activity of Genistein and Epicatechin

Geeta

Widodo²,

Widowati

et al. 2019

psr

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Background: Skin aging is a complex natural process caused by both intrinsic or genetically programmed aging and extrinsic aging caused by environmental factors, such as free radical. The use of antioxidant and anti-collagenase to prevent the aging proses has been known. Natural compounds from plants are one of the sources of antioxidant and anti-collagenase that has ability to prevent aging. Genistein and Epicatechin are the major phenolic compound found in G. max. Objectives: This research was to evaluate the antiaging potential of genistein and epicatechin through antioxidant activity assay (ABTS-reducing activity assay) and collagenase inhibitory activity assay. Methods: Antioxidant analysis of Genistein and Epicatechin was performed by 2,2'-azinobis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS) reducing activity Assay. Antiaging assay was conducted through inhibitory of collagenase, one of important enzyme in aging process. Results: ABTS-reducing activity assay showed that both compounds had great ABTS-reducing activity in which epicatechin had better activity than genistein. Epicatechin had low value of IC 50 ABTS-reducing activity around 14.39 µg/ml better than genistein with IC 50 about 43.17 µg/ml. In terms of collagenase inhibitory activity assay, epicatechin had lower value of IC 50 (9.08+-3.46 ug/ml), better than genistein (98.74+-4.25 ug/ml). Conclusion: Epicatechin had higher antioxidant and anti-collagenase activity compared to Genistein.

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Antioxidant and anti-collagenase activity of Hypericum hircinum L.

Cited by 54 publications

References 36 publications

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Variability of Hypericins and Hyperforin inHypericumSpecies from the Sicilian Flora

Comparison of Antioxidant and Anti-collagenase Activity of Genistein and Epicatechin

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