Antioxidant and anti-diabetic activities of bioactive fractions of Carica papaya seeds extract

Agada, Reuben; Dluya, Thagriki; Lydia, D. Esther; Khusro, Ameer; Alkahtani, Jawaher; Shaqha, Manal M. Al; Alwahibi, Mona S.; Elshikh, Mohamed S.

doi:10.1016/j.jksus.2021.101342

Cited by 26 publications

(9 citation statements)

References 19 publications

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“…The DPPH· radical scavenging ability, FRAP reducing power, and ABTS + · radical scavenging ability of different solvent extracts of highland barley bran increased with an increasing extract dosage, showing a dose-dependent relationship ( Figure 1 ). This phenomenon has been commonly observed in the antioxidant activity studies of different plant extracts [ 33 , 34 ]. The antioxidant capacity of the barley bran acetone extract was overall the highest among all extracts ( Figure 1 A–C).…”

Section: Resultsmentioning

confidence: 65%

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

et al. 2023

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Five different solvent extracts of highland barley bran were analyzed and compared for their polyphenol profile, antioxidant activity, and α-glucosidase and α-amylase inhibitory activities. The highland barley bran acetone extract had the highest total phenolic content, total flavonoid content, and antioxidant capacity. It was followed by the methanol and ethanol extracts, while n-butanol and ethyl acetate extracts exhibited lower measured values. Diosmetin, luteolin, protocatechuic acid, vanillic acid, ferulic acid, phlorogucinol, diosmin, isoquercitrin, catechin, and isovitexin were among the most abundant phenolic compounds identified in different solvent extracts, and their concentrations varied according to the solvent used. The highest α-glucosidase and α-amylase inhibitory activity were observed in the ethyl acetate extract of highland barley bran, followed by the acetone and methanol extracts. In contrast, n-butanol and ethanol extracts exhibited lower measured values. The different solvent extracts were effective inhibitors for α-glucosidase and α-amylase with activity reaching to 34.45–94.32% and 22.08–35.92% of that of positive control acarbose, respectively. There were obvious correlations between the phenolic content and composition of different solvent extracts and their in vitro antioxidant activity, α-glucosidase inhibition activity and α-amylase inhibition activity. Black barley bran is an excellent natural raw material for developing polyphenol-rich functional foods and shows good antioxidant and hypoglycemic potential to benefit human health.

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Section: Resultsmentioning

confidence: 65%

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

et al. 2023

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“…The antioxidant, n-hexadecanoic acid can protect our body from tissue damage [48] and the heptadecanoic acid can prevent pre-diabetes from human [49] . Similar studies were done by researchers on herbal extractions, explored the pharmaceutical biological activities [50] .…”

Section: Table 1: Effects Of S Oblonga Stem Extracts In Normal Rats B...mentioning

confidence: 68%

Antihyperglycemic Activity Antioxidant Enzymes and Histopathological Studies of Salacia oblonga in Streptozotocin Nicotinamide Induced Type 2 Diabetic Rats

Malar¹,

Chellaram²

2022

IJPS

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Malar et al.: In vivo Antidiabetic Activity of Stem Extracts of Salacia oblongaSalacia oblonga (Celastraceae), a traditional ayurvedic herbal plant commonly called as ponkoranti. The antidiabetic and Histopathological studies of aqueous stem extracts of Salacia oblonga carried in Streptozotocin-nicotinamide induced diabetic rats which were orally treated with glibenclamide and Salacia oblonga stem extracts at lower (250 mg/kg) and higher (500 mg/kg) concentrations. The normal rats were administrated for the oral glucose tolerance test at 0, 30, 60 and 120 min after glucose load. Fasting blood glucose levels were measured by glucose oxidase strips and glucometer. The protective effect was evaluated by studying the effect of antioxidant enzymes, lipid peroxidation and Histopathological changes after the treatment period. Treatment done with 500 mg/kg of stem extract produced more effect with improved protein (1.18±1.45 mg), superoxide dismutase (229.15±1.52 U/mg protein), Catalase (19.51±1.35 U/min/mg protein), Glutathione (1.54±.29 U/min/mg protein), Glutathione peroxidase (1.74±1.56 U/min/mg) and reduced lipid peroxidation (1.76±2.31 µm/min/mg). From the study, it was found that the stem extracts potentially increase the antioxidants and reduced the lipid peroxidation. The rats which were treated with Salacia oblonga and glibenclamide significantly reduced the glucose level (p<0.001). Histopathological alterations were restored after the treatment with stem extracts of Salacia oblonga at lower and higher concentrations. The significant effect on the vital organs such as liver and pancreas demonstrates the herbal usage of potential endangered plant. The spectral analysis (gas chromatography-mass spectrometry) explored the potential natural chemical constituents which were responsible for the antioxidant and antidiabetic activity. Further preclinical and clinical trials are required to confirm the potential of Salacia oblonga stem extract.

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“… S.No Compound RT RI RI (reference) Area % Match % Antioxidant Activity 1 12.803 – – 0.23 86 [ 38 , 39 ] 2 16.845 984.095 – 1.85 91 [ 40 , 41 ] 3 27.016 1460.25 – 6.84 94 [ 41 , 42 ] 4 27.953 1518.66 – 8.58 95 [ [42] , [43] , [44] , [45] , [46] ] 5 30.416 1666.26 – 8.04 93 [ 41 ] 6 30.549 1673.69 – 1.80 94 …”

Section: Resultsmentioning

confidence: 99%

Phytochemical analysis, GC-MS characterization and antioxidant activity of Hordeum vulgare seed extracts

Farooqi,

Naveed,

Qamar

et al. 2024

Heliyon

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Antioxidant and anti-diabetic activities of bioactive fractions of Carica papaya seeds extract

Cited by 26 publications

References 19 publications

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran

Antihyperglycemic Activity Antioxidant Enzymes and Histopathological Studies of Salacia oblonga in Streptozotocin Nicotinamide Induced Type 2 Diabetic Rats

Phytochemical analysis, GC-MS characterization and antioxidant activity of Hordeum vulgare seed extracts

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