Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract

Ji, Jin; Xin, Yang; Flavel, Matthew; Shields, Zenaida P.; Kitchen, Barry J.

doi:10.1080/07315724.2019.1587323

Cited by 46 publications

(55 citation statements)

References 25 publications

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“…Extract is concentrated to 70 Brix in a Buchi Rotary Evaporator. Quantification of general antioxidant capacity with both chemical (6-radical Oxygen Radical Absorption Capacity assay, ORAC 6.0) and biological (Cellular antioxidant assay, CAA) quantification methods were also carried out as previously described (6).…”

Section: Study Materialsmentioning

confidence: 99%

“…The high level of polyphenols in the concentrate correlated with the strong antioxidant capacity of Officinol™, which exhibited a full spectrum oxidant absorption capacity against six primary radicals (peroxyl radical, hydroxyl radical, superoxide anion, singlet oxygen, peroxynitrite, and hypochlorite), with a total antioxidant capacity (ORAC 6.0) assessed at 1668.27 µmole trolox equivalency (TE)/g (shown in Table 1) using methods described previously (6). As exhibited in Table 4, the antioxidant capacity of Officinol™ is at an order of 2-10 magnitudes higher than that of raw fruits or juices, even dry fruits and cocoa powder that are known to contain high levels of antioxidants.…”

Section: Officinol™ Provides Anti-aging Function Possibly Through Acmentioning

confidence: 99%

“…We recently reported that a polyphenol rich sugarcane extract (PRSE) obtained from sugarcane molasses using a patented extraction process contains a high level of phenolic compounds including tricin, apigenin, and luteolin, and displays a full spectrum of antioxidant property that effectively neutralizes six different species of ROS [6]. In another study, we also examined the anti-inflammatory effect of Officinol™ via its inhibitive effect on pro-inflammatory cytokine tumor necrosis factor (TNF-α) and activation effect on nuclear factor erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor deployed by a cellular system to counter oxidative stress and inflammation [7].…”

Section: Introductionmentioning

confidence: 99%

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Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Jin

Xin²,

Flavel³

et al. 2020

Cosmetics

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Increasing evidence suggests that environmental stress, such as UV radiation, generates reactive oxygen and nitrogen species in skin cells, leading to histochemical changes including skin disorders and aging, hyper pigmentation, and increased formation of wrinkles. Besides the defensive system in skin composed of vitamins and intrinsic antioxidant enzymes, topical and skin conditioning products have been used commonly to eradicate or eliminate these skin ailments. Among various ingredients providing nourishing and moisturizing effect in skin, antioxidants have been reported to be a key ingredient to counteract skin aging processes and skin disorders. Derived from a patented extraction process, a polyphenol rich sugarcane concentrate (Officinol™) becomes the focus of this study due to its rich content of polyphenols known to be strong antioxidants. In this work, we carried out a series of cell-based in vitro studies to examine the use of Officinol™ in anti-aging and skin care functions. Our studies show that Officinol™ activated telomerase, a major biomarker that have been reported to be associated with slowed cellular aging process. When skin cells were under environmental stress such as UV radiation, Officinol™ inhibited MMP-1, an interstitial collagenase in skin cells, and deterred the breakdown of collagen that provides supple texture in skin. Officinol™ also inhibited cellular expression of melanin pigmentation and tyrosinase activity, two major biomarkers causing skin pigmentation and aging spots, and inhibited elastase, an enzyme that facilities the reduction of skin elasticity. At the end of the investigation, we carried out a 10-person, pilot study to examine the effect of Officinol™ on skin lightening and fine line and wrinkle reduction in human skin. The combination of the in vitro and the human pre-study indicates that Officinol™ could provide significant preventative and protective functions including antioxidant, anti-aging, wrinkle reduction, and skin brightening for human skin suffering from aging and other stress. These findings are to be confirmed with a larger scale clinical study at a later stage.

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Section: Study Materialsmentioning

confidence: 99%

Section: Officinol™ Provides Anti-aging Function Possibly Through Acmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Jin

Xin²,

Flavel³

et al. 2020

Cosmetics

Self Cite

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“…Penicillin-streptomycin was obtained from Sigma Aldrich (Castle Hill, NSW Australia). PRSE, isolated and purified from sugar cane as previously described [36] and was provided by The Product Makers (Australia) Pty Ltd (Keysborough, VIC Australia).…”

Section: Bacterial Strains and Materialsmentioning

confidence: 99%

Polyphenol Rich Sugar Cane Extract Inhibits Bacterial Growth

Ahtesh

Stojanovska

Feehan

et al. 2020

Prilozi

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Plants that are primarily used as a food source commonly have undervalued biological properties beyond the basic supply of nutrients. One important example of this are the antimicrobial properties of plants. Inclusion of natural and food grade antimicrobial ingredients in recipes to prevent food spoilage and disease transmission, or in cosmetic products to prevent transient and pathogenic bacteria would have world-wide public health implications. A patented natural polyphenol rich sugar cane extract (PRSE), is marketed as a high anti-oxidant and polyphenol ingredient, but its anti-microbial activity has not been reported previously. We determined the anti-bacterial properties of PRSE on common human pathogens relating to a range of diseases including food poisoning, tooth decay, acne and severe skin infections using disc/well diffusion experiments. Our findings indicate that PRSE is an efficient antimicrobial, which could be included at differing dosages to target a range of food borne and environmental pathogens.

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“…This makes it an attractive target for further utilization in the development of "nutraceuticals", as it is readily available, cost-effective and safely edible. A novel preparation named "polyphenol-rich sugarcane extract" (PRSE) has been shown to have a large concentration of both polyphenols and other antioxidant compounds, and has been shown to have some beneficial effects on energy uptake and metabolism in cancer cells, as well as being able to impact the actions of insulin-secreting pancreatic β-cells [24]. It is also able to impart benefits in diabetes, has anti-bacterial effects and improves the cosmetic effects of aging in the skin [25].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

et al. 2021

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As inflammatory lifestyle factors become more prevalent and as the population ages, the management of inflammation will become increasingly relevant. Plant polyphenols are powerful antioxidants that are known to have beneficial effects in a number of diseases with an inflammatory or oxidative component, such as malignancy, cardiovascular disease and arthritis. Polyphenol-rich sugarcane extract (PRSE) is a novel preparation with high concentrations of polyphenolic antioxidants, with some evidence to show benefits in health, but there is limited research investigating its effects on immunomodulation. This study determined the effects of PRSE on human monocyte cells in vitro. We show that PRSE has an immunomodulatory effect in U937 human monocyte cells, altering the expression of cellular surface markers, with an increased expression of CD16 and CD11b, as well as small changes in CD40, CD80, CD80, CD206 and MHCI. It also modulates the profile of secreted cytokines, increasing IL-1β, TNFα, IL-6, IL-8, IL-4 and IL-10. These changes are consistent with the advanced differentiation of the monocyte, as well as the switch from the M1 to M2 phenotype in macrophages. We also demonstrate that this effect is likely to be independent of the NF-κB signalling pathway, suggesting that other mechanisms drive this effect. PRSE exerts an immunomodulatory effect on U937 monocytes in vitro, potentially facilitating the conversion from inflammation to healing. Future studies should identify specific mechanisms underlying the changes and evaluate their effectiveness in animal models of disease.

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Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract

Cited by 46 publications

References 25 publications

Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate

Polyphenol Rich Sugar Cane Extract Inhibits Bacterial Growth

Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes

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