Antioxidant and anti-hyperglycaemic activity of &lt;i&gt;Euphorbia hirta&lt;/i&gt; L. on Wistar rats

Fofie, Y N'Guessan Bra; Sanogo, Rokia; Diarra, B; Kanadjigui, F; Kone-Bamba, Diénéba

doi:10.4314/ijbcs.v7i6.30

“…The antioxidant capacity of the fruits was measured by evaluating the ability to react with free radicals using DPPH stable radical. DPPH has been widely used to evaluate the free radical scavenging effectiveness of various plant materials (Fofie et al, 2013;Zintchem et al, 2013;Agboola, 2014;Koevi, 2015). Most free radicals are constantly generated in the human body as byproducts during the normal process of oxidation and they are implicated in many human diseases including accelerated ageing, cancer, cardiovascular diseases, neurodegenerative disease and inflammation (Bhattacharya, 2015).…”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

Nutritional content and antioxidant properties of edible indigenous wild fruits from miombo woodlands in Tanzania

Mapunda¹,

Mligo²

2019

Int. J. Bio. Chem. Sci

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Edible fruits of four indigenous plants (Uapaca kirkiana, Strychnos cocculoides, Syzygium guineense and Ximenia caffra) from miombo woodlands of Ruvuma Region in Tanzania were evaluated for nutritional composition and antioxidant properties. Fruits from the four plants were collected for extraction of the edible portion that was subsequently subjected to laboratory analysis using standard procedures. Soluble carbohydrates dominated among macronutrients evaluated (16.326 to 56.001%) and potassium was the most abundant mineral nutrient among those studied with the concentration ranging from 429.4 to 671.73 mg/100 g. The total phenolic contents, flavonoids and vitamin C in X. caffra were 1915.88 mg GAE/100 g, 178.46 mg RE /100 g and 359.90 mg/100 g respectively which are significantly higher than those in other species studied. Similarly, X. caffra showed significantly higher free radical scavenging activity with lower EC 50 (effective concentration for free radical reduction by 50%) achieved at 0.08 µg/ml than other fruit species studied. A strong positive correlation was observed between free radical scavenging activities with vitamin C (r = 0.973), total phenolics (r = 0.866) and flavonoids (r = 0.858). These observations imply that indigenous fruits studied could be used as valuable sources of nutrients and vital natural antioxidant to human diets.

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In vitro, antioxidant activities of aqueous and methanol roselle (Hibiscus sabdariffa) calyces extracts from two localities in Cameroon

Tazoho

¹

,

Agbor

²

,

Gouado

³

2020

Nor. Afr. J. Food Nutr. Res.

0

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Background: Fighting against malnutrition and diseases such as oxidative stress diseases via a food-based approach could be achieved through identification, valorization, and promotion of local foods rich in macro- and micronutrients and phytochemical components. Aim: This study aimed to investigate the effect of agro-ecological conditions on the antioxidant capacity of the Hibiscus sabdariffa aqueous and methanol calyces extracts. Material and methods: The total phenolic content, the free radical DPPH• (1,1-diphenyl-2-picrylhydrazyl), and ferric reducing antioxidant power (FRAP) activities were evaluated in aqueous and methanol Hibiscus sabdariffa calyces extract samples from two localities (Dschang [western highland zone] and Ngaoundéré [high Guinean savanna zone]) in Cameroon. Results: The results obtained showed that these extracts contain an important amount of total phenolic compounds with no significant difference (P>0.05) between aqueous and methanol extracts and also between the origins of calyces. The extracts showed their ability to reduce Fe3+ to Fe2+ as well as their ability to reduce the free radical, DPPH•. Concerning the FRAP results, at the concentration of 12.5µg/mL, the absorbance of AEN (Aqueous Extract from Ngaoundéré locality) recorded the value (0.33±0.05) meanwhile at a far higher concentration of 200 µg/mL, the absorbance of MEN (Methanol Extract from Ngaoundéré locality) was the highest (1.39±0.06). The CI50 of methanol extracts was significantly low (P<0.05) compared to that of aqueous extracts. The value ranges were 11.31±0.15, 14.69±0.84, 18.07±0.63, 20.50±0.54, and 21.50±0.54 µg/mL for ascorbic acid, MEN (Methanol Extract from Ngaoundéré locality), MED (Methanol Extract from Dschang locality), AEN (Aqueous Extract from Ngaoundéré locality), and AED (Aqueous Extract from Dschang locality) respectively. Conclusion: These findings show that the antioxidant activity of methanol extract is higher than that of aqueous extract. Hibiscus calyces from the two localities could be used as a natural antioxidant in the treatment of oxidative stress diseases. Keywords: Roselle calyces, aqueous and methanol extracts, antioxidant capacity.

show abstract

In vitro, antioxidant activities of aqueous and methanol roselle (Hibiscus sabdariffa) calyces extracts from two localities in Cameroon

Tazoho

¹

,

Agbor

²

,

Gouado

³

2020

Nor. Afr. J. Food Nutr. Res.

1

0

View full text Add to dashboard Cite

Background: Fighting against malnutrition and diseases such as oxidative stress diseases via a food-based approach could be achieved through identification, valorization, and promotion of local foods rich in macro- and micronutrients and phytochemical components. Aim: This study aimed to investigate the effect of agro-ecological conditions on the antioxidant capacity of the Hibiscus sabdariffa aqueous and methanol calyces extracts. Material and methods: The total phenolic content, the free radical DPPH• (1,1-diphenyl-2-picrylhydrazyl), and ferric reducing antioxidant power (FRAP) activities were evaluated in aqueous and methanol Hibiscus sabdariffa calyces extract samples from two localities (Dschang [western highland zone] and Ngaoundéré [high Guinean savanna zone]) in Cameroon. Results: The results obtained showed that these extracts contain an important amount of total phenolic compounds with no significant difference (P>0.05) between aqueous and methanol extracts and also between the origins of calyces. The extracts showed their ability to reduce Fe3+ to Fe2+ as well as their ability to reduce the free radical, DPPH•. Concerning the FRAP results, at the concentration of 12.5µg/mL, the absorbance of AEN (Aqueous Extract from Ngaoundéré locality) recorded the value (0.33±0.05) meanwhile at a far higher concentration of 200 µg/mL, the absorbance of MEN (Methanol Extract from Ngaoundéré locality) was the highest (1.39±0.06). The CI50 of methanol extracts was significantly low (P<0.05) compared to that of aqueous extracts. The value ranges were 11.31±0.15, 14.69±0.84, 18.07±0.63, 20.50±0.54, and 21.50±0.54 µg/mL for ascorbic acid, MEN (Methanol Extract from Ngaoundéré locality), MED (Methanol Extract from Dschang locality), AEN (Aqueous Extract from Ngaoundéré locality), and AED (Aqueous Extract from Dschang locality) respectively. Conclusion: These findings show that the antioxidant activity of methanol extract is higher than that of aqueous extract. Hibiscus calyces from the two localities could be used as a natural antioxidant in the treatment of oxidative stress diseases. Keywords: Roselle calyces, aqueous and methanol extracts, antioxidant capacity.

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Antioxidant and anti-hyperglycaemic activity of <i>Euphorbia hirta</i> L. on Wistar rats

Cited by 4 publications

References 18 publications

Nutritional content and antioxidant properties of edible indigenous wild fruits from miombo woodlands in Tanzania

Nutritional content and antioxidant properties of edible indigenous wild fruits from miombo woodlands in Tanzania

In vitro, antioxidant activities of aqueous and methanol roselle (Hibiscus sabdariffa) calyces extracts from two localities in Cameroon

In vitro, antioxidant activities of aqueous and methanol roselle (Hibiscus sabdariffa) calyces extracts from two localities in Cameroon

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