Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis

Xu, Nuo; Ren, Zhenzhen; Zhang, Jianjun; Song, Xinling; Gao, Zheng; Jing, Huijuan; Li, Shangshang; Wang, Shouxian

doi:10.1016/j.ijbiomac.2016.11.060

Cited by 55 publications

(32 citation statements)

References 33 publications

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“…Although the role of monosaccharides in the antioxidant activity of polysaccharides remained unclear, there is evidence that the composition and ratios of monosaccharide type influence the antioxidant properties. The results confirm previous reports that galactose, uronic acid content and the complexity of monosaccharide composition in polysaccharides play key roles in their antioxidant activity [47,48]. Additionally, the antioxidant capacity of the current CPv-PS could be attributed to the hydroxyl groups (-OH).…”

Section: Discussionsupporting

confidence: 89%

“…Such evidence confirm that polysaccharides have a significant protection effect on Cd-induced reduction of cell viability and the damnification of HepG2 cells, although the mechanism requires further study.Subsequently, hepatoprotective effect of CFv-PS was evaluated. ALAT, ASAT, as well as bilirubin activities, which could leach out of hepatocytes into blood circulation resulting the enhancement of atherosclerosis and blood viscosity[47], are widely used to evaluate liver damage. Herein, serum activities were significantly increased (P < 0.05) after Cd treatment,…”

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confidence: 99%

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Polysaccharides from Phormidium versicolor (NCC466) protecting HepG2 human hepatocellular carcinoma cells and rat liver tissues from cadmium toxicity: Evidence from in vitro and in vivo tests

Belhaj

Athmouni

Aoiadni

et al. 2018

International Journal of Biological Macromolecules

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The in vitro antioxidant, cytotoxic and cytoprotective properties and in vivo hepatoprotective activities of crude polysaccharides extracted from cyanobacteria Phormidim versicolor NCC466 (CFv-PS) were investigated. The CFv-PS, identified as heteropolysaccharides with molecular weight of 63.79kDa, exhibited relatively strong antioxidant activity, in a concentration-depended manner, in vitro assays. Additionally, CFv-PS did not induce cytotoxic effect on HepG2 human hepatocellular carcinoma cells within the range of tested concentrations (25-150μg·mL) while preventing them against Cd. Moreover, in rats subjected to Cd-induced hepatotoxicity, CFv-PS pretreatment significantly (P<0.05) reduced the level of ALAT, ASAT, biliburin, MDA, protein carbonyl and DNA damage, and markedly increased enzyme activities in liver tissues. These findings suggest that the cyanobacteria Phormidium versicolor is a potential source of natural products possessing antioxidant, cytoprotective and hepatoprotective properties.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Polysaccharides from Phormidium versicolor (NCC466) protecting HepG2 human hepatocellular carcinoma cells and rat liver tissues from cadmium toxicity: Evidence from in vitro and in vivo tests

Belhaj

Athmouni

Aoiadni

et al. 2018

International Journal of Biological Macromolecules

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“…Lovastatin not only reduces blood cholesterol, but it also has anti-inflammatory, anticoagulation, antioxidative, anti-fungal, and anti-carcinogenic effects [23,24]. Acidic and alkalic-extractable zinc polysaccharides extracted from P. eryngii mycelia have demonstrated hepatoprotective and antioxidant effects [25]. P. eryngii contains the highest total glucan concentrations among Pleurotus spp., concentrated mainly in stalk and the highest α-glucans proportion.…”

Section: Introductionmentioning

confidence: 99%

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

et al. 2020

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Pleurotus eryngii (DC:Fr.) Quel. is a cultivated mushroom of high culinary value and medicinal properties. Mycelium of P. eryngii is characterized by the ability of effective bio-elements absorption from growth media so it could be biofortified with trace elements with a functional activity in the human body. In this study, the ability of P. eryngii mycelia from in vitro cultures as well as fruiting bodies were investigated in terms of their effectiveness in zinc and selenium accumulation. The effect of Se and Zn biofortification on productivity, chemical compounds, and bio-elements content of P. eryngii was determined as well. To enhance Se and Zn content in P. eryngii fruiting bodies and mycelia, substrates were supplemented with sodium selenite, at a concentration of 50 mg L−1, zinc sulfate, and zinc hydro-aspartate at a concentration of 87.2 and 100.0 mg L−1, respectively. Mentioned Zn concentrations contained the same amount of zinc(II) ions, namely 20 mg L−1. The content of organic compounds include phenolic compounds and lovastatin, which were determined by a high-performance liquid chromatography with diode-array detector (HPLC-DAD) and reverse phase high-performance liquid chromatography (RP-HPLC) method with UV detection. The ability of P. eryngii to accumulate zinc and selenium from the culture medium was demonstrated. The degree of accumulation of zinc turned out to be different depending on the type of salt used. The present study also showed that conducting mycelium of P. eryngii in in vitro culture, with a higher content of zinc ions, can result in obtaining the materials with better antioxidant ability. The results of this study can be used to develop the composition of growing media, which ensures the production of biomass with the desired composition of elements.

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“…Its activities have been proven to be related to the abundance and diversity of active components. A wealth of research has reported the preparation of functional proteins (Yuan et al, 2017), polyphenols (Mishra et al, 2013), peptides (Sun, Hu, & Li, 2017), essential fatty acids (Çayan, Tel-Çayan, Ozler, & Duru, 2017), and polysaccharides (S. Li & Shah, 2017;Ren et al, 2017) from P. eryngii, as well as their activities against numerous health problems. Polysaccharide fractions have been shown to be the major biological components in P. eryngii and displayed multiple and significant functional properties such as inhibitory effects on renal cancer cells (Yang et al, 2013), hyperlipidemia and hyperglycemia (Chen, Zhang, Sha, Xu, & Wang, 2016), lipid accumulation (J.…”

Section: Introductionmentioning

confidence: 99%

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti‐inflammation activities potential

Kimatu

Yang

et al. 2020

Journal of Food Science

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The anti‐inflammatory effects of two newly identified Pleurotus eryngii polysaccharides (WPEP, NPEP) were determined in lipopolysaccharide (LPS)‐stimulated RAW264.7 macrophages in this study. Characterization analysis revealed that molecular weights of WPEP and NPEP were 167 and 274 kDa, and were mainly composed of glucose with β‐type glycosidic linkages. WPEP and NPEP could significantly inhibit LPS‐induced inflammatory responses by regulating the production of NO, Protaglandin E2 (PGE2), Interleukin‐1β (IL‐1β), Tumor necrosis factor‐α (TNF‐α), and Interleukin‐6 (IL‐6). This was through the blocking of the activation of Mitogen‐activated protein kinase (MAPK) pathway by inhibiting phosphorylation of p38, extracellular regulation of protein kinases 1/2, and stress‐activated protein kinase/jun aminoterminal kinase. Moreover, WPEP and NPEP inhibited NF‐κB signaling by reducing nuclear translocation and phosphorylation of p65. Overall, our results, for the first time identified two P. eryngii polysaccharides and demonstrated the related anti‐inflammatory effects, which indicated the favorable potential of P. eryngii polysaccharide as specific functional foods. Practical Application This study prepared and characterized newly identified Pleurotus eryngii water‐soluble polysaccharide fractions and elucidated the nutritional benefits, mainly the immune response related to anti‐inflammatory activities by utilizing lipopolysaccharide (LPS)‐stimulated RAW264.7 cells. Collectively, results of this study suggested that the P. eryngii polysaccharide fractions could be considered as potential candidates for exploration in the development of new immunomodulatory agent or functional supplementary foods.

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Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis

Cited by 55 publications

References 33 publications

Polysaccharides from Phormidium versicolor (NCC466) protecting HepG2 human hepatocellular carcinoma cells and rat liver tissues from cadmium toxicity: Evidence from in vitro and in vivo tests

Polysaccharides from Phormidium versicolor (NCC466) protecting HepG2 human hepatocellular carcinoma cells and rat liver tissues from cadmium toxicity: Evidence from in vitro and in vivo tests

Selenium and Zinc Biofortification of Pleurotus eryngii Mycelium and Fruiting Bodies as a Tool for Controlling Their Biological Activity

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti‐inflammation activities potential

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