Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract

Nagajyothi, P.C.; Ju, Sang Gyu; Yang, In Jun; Sreekanth, T.V.M.; Kim, Kwang Joong; Shin, Heung Mook

doi:10.1016/j.jphotobiol.2015.02.008

Cited by 444 publications

(202 citation statements)

References 50 publications

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“…Surprisingly, our results showed that ZnONPs could treat HCC as evidenced by decreased AFP and AFU levels coupled with amelioration of oxidative stress and improvement of antioxidant defense system. Our findings are in harmony with previous findings by Nagajyothi et al . who reported that ZnONPs posses a good antioxidant effect, which was attributed to its anti‐inflammatory potential mediated by down‐regulation of iNOS, cyclo‐oxygenase‐2 and various cytokines.…”

Section: Discussionsupporting

confidence: 92%

“…The ZnONPs were reported to possess opposing effects, probably based on the model, the cell type and the dose. Some authors reported that ZnONPs possess antioxidant effects, while others claim that ZnONPs increase reactive oxygen species (ROS) generation inside cells . To date, no study has been performed regarding the anticancer effect of ZnONPs in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Hassan

Mansour

Abo-Youssef

et al. 2017

Clin Exp Pharma Physio

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Currently, the outcomes of conventional chemotherapeutic approaches are unsatisfactory. Clinical application of nanoparticles seems promising. We aim to evaluate the possible antitumor activity of zinc oxide nanoparticles (ZnONPs) as a chemotherapeutic approach in in vitro and in vivo experimental models. An in vitro study was performed on three different cell lines, namely human hepatocellular carcinoma (HEPG2), human prostate cancer (PC3), and none-small cell lung cancer (A549) cell lines. An in vivo study using diethylnitrosamine (DENA)-induced HCC in adult male Wistar rats was conducted to investigate the potential antitumor activity of ZnONPs in HCC and the possible underlying mechanisms. Hepatocellular carcinoma (HCC) was induced by oral administration of DENA given in drinking water (100 mg/L) for 8 weeks. Rats were allocated into four groups, namely a control group, an HCC control group receiving DENA alone, a ZnONPs (10 μg/kg per week, intravenous (i.v.) for 1 month) control group, and a ZnONPs treatment group (receiving ZnONPs + DENA). ZnONPs significantly reduced the elevated serum levels of HCC-related tumor markers alphafetoprotein and alpha-l-fucosidase and the apoptotic marker caspase-3 compared with the untreated HCC rats. In addition, treatment with ZnONPs significantly decreased the elevated levels of hepatocyte integrity and oxidative stress markers as compared with the untreated HCC control group. Furthermore, the histopathological study revealed anaplasia and fibrous degenerations which were significantly corrected by ZnONPs treatment. In conclusion, administration of ZnONPs exhibited a promising preclinical anticancer efficacy in HCC and could be considered as a novel strategy for the treatment HCC in clinical practices.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Hassan

Mansour

Abo-Youssef

et al. 2017

Clin Exp Pharma Physio

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“…DPPH Radical Scavenging Activity The 2, 2-diphenyl-1picrylhydrazyl (DPPH) radical scavenging assay was determined by the method of [19] with some modifications. The DPPH scavenging ability was calculated by the following formula:…”

Section: Antioxidant Activitymentioning

confidence: 99%

Green Synthesis of Selenium Nanoparticle Using Leaves Extract of Withania somnifera and Its Biological Applications and Photocatalytic Activities

2018

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The green Se NPs (selenium nanoparticles) are formed by simple mixing of Withania somnifera (W. somnifera) leaves extract and selenious acid (H 2 SeO 3 ) solution. This mixture was stirred which gave a dispersion of Se NPs conjugated with W. somnifera secondary metabolites. The work was focused to determine the phytochemical analysis of leaves extract, green synthesis, its characterization and its applications. Screening analysis showed enormous phytoconstituents in leaves aqueous extract and simultaneously, the synthesized Se NPs by FT-IR spectrum confirm the presence of functional groups which were associated with bioactive molecules. The total flavonoid, phenolic and tannin contents in the aqueous extract were found to be 12.74, 40.54, and 156.33 μg/mg respectively. The suspension solution confirms the formation of Se NPs showed (310 nm) by UVanalysis. Xray diffraction study exhibits the amorphous nature of Se NPs. Se NPs were spherical in shape within the diameter range of 45-90 nm by FE-SEM. The intense, narrow width of selenium has high purity and was identified using EDX. The TEM analysis exhibited the amorphous nature of particles. Green synthesized Se NPs were found to possess significant antioxidant activity (IC 50 -14.81 μg/mg) and considerable antibacterial activity on Bacillus subtilis (12 mm), Klebsiella pneumoniae (14 mm) and Staphylococcus aureus (19.66 mm). Antiproliferative effects of Se NPs possess great growth control against A549 cells (IC 50 at 25 μg/ml). Se NPs exhibit efficient methylene blue (MB) dye degradation in the presence of sunlight. The present results support the advantages of green method for the production of Se NPs having potential activities. Highlights• Withania somnifera leaves extract possesses active phytoconstituents and acts as reducing agents for the preparation of Se NPs and the capping by the phytoconstituents providing stability to Se NPs as evident from FT-IR studies. • The green synthesized metal nanoparticle has emerged at low cost, simpler and better choice than physical and chemical methods.• Green synthesized Se NPs were found to be almost spherical in shape with particle size around 40-90 nm, selenium has high purity and crystalline nature was identified using EDX and XRD. • The DPPH scavenging analysis of the amorphous Se NPs has significant antioxidant activity and serves as a potential antibacterial agent to treat diseases caused by bacteria. • Antiproliferative activity results suggest that Se NPs possess higher growth control against A549 lung carcinoma cancer cells (IC 50 at 25 μg/ml) which indicated their potential in medical applications. • The photocatalytic study concludes that these Se NPs have efficiency to degrade MB under sunlight irradiation. Therefore, they can find application in water treatment plants and textile industries.

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“…34 Anti-inflammatory activity of ZnO-NPs has been previously reported. 35 However, to the best of the authors' knowledge, to date, there have been no reports to discuss the anti-inflammatory activity of zinc peroxide nanoparticles (ZnO 2 -NPs) for further in vivo application as a novel ointment in the treatment of burn wounds.…”

mentioning

confidence: 99%

Synthesized zinc peroxide nanoparticles (ZnO<sub>2</sub>-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds

Ali¹,

Morsy²,

El-Zawawy³

et al. 2017

IJN

121

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Increasing of multidrug resistance (MDR) remains an intractable challenge for burn patients. Innovative nanomaterials are also in high demand for the development of new antimicrobial biomaterials that inevitably have opened new therapeutic horizons in medical approaches and lead to many efforts for synthesizing new metal oxide nanoparticles (NPs) for better control of the MDR associated with the polymicrobial burn wounds. Recently, it seems that metal oxides can truly be considered as highly efficient inorganic agents with antimicrobial properties. In this study, zinc peroxide NPs (ZnO 2 -NPs) were synthesized using the co-precipitation method. Synthesized ZnO 2 -NPs were characterized by X-ray diffraction, Fourier transformed infrared, transmission electron microscopy, thermogravimetric analysis, differential scanning calorimetry, and ultraviolet-visible spectroscopy. The characterization techniques revealed synthesis of the pure phase of non-agglomerated ZnO 2 -NPs having sizes in the range of 15–25 nm with a transition temperature of 211°C. Antimicrobial activity of ZnO 2 -NPs was determined against MDR Pseudomonas aeruginosa (PA) and Aspergillus niger (AN) strains isolated from burn wound infections. Both strains, PA6 and AN4, were found to be more susceptible strains to ZnO 2 -NPs. In addition, a significant decrease in elastase and keratinase activities was recorded with increased concentrations of ZnO 2 -NPs until 200 µg/mL. ZnO 2 -NPs revealed a significant anti-inflammatory activity against PA6 and AN4 strains as demonstrated by membrane stabilization, albumin denaturation, and proteinase inhibition. Moreover, the results of in vivo histopathology assessment confirmed the potential role of ZnO 2 -NPs in the improvement of skin wound healing in the experimental animal models. Clearly, the synthesized ZnO 2 -NPs have demonstrated a competitive capability as antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory candidates, suggesting that the ZnO 2 -NPs are promising metal oxides that are potentially valued for biomedical applications.

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Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract

Cited by 444 publications

References 50 publications

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence

Green Synthesis of Selenium Nanoparticle Using Leaves Extract of Withania somnifera and Its Biological Applications and Photocatalytic Activities

Synthesized zinc peroxide nanoparticles (ZnO<sub>2</sub>-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds

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