Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves

Fu, Rao; Zhang, Yuting; Guo, Yiran; Huang, Qiu-Lan; Peng, Tong; Xu, Ying; Tang, Lin; Chen, Fang

doi:10.1016/j.jep.2013.03.058

Cited by 53 publications

(33 citation statements)

References 31 publications

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“…IC 50 values were calculated as the minimum concentration of each sample required to decrease the DPPH radical concentration by 50%. ABTS assay: The radical scavenging activity was also spectrophotometrically evaluated based on monitoring the disappearance of ABTS at 734 nm using the method of Rao Fu et al with minor modification (14). An ABTS solution was diluted using ethanol to an absorbance value (Lambda 25; Perkin Elmer) of (0.70±0.02) at 734 nm and equilibrated at 30 o C (HH-2; Changzhou Sino Instrument Co., Ltd.).…”

Section: Determination Of Polyphenol Contentsmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

Wang

et al. 2015

Food Sci Biotechnol

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Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.

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Section: Determination Of Polyphenol Contentsmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

Wang

et al. 2015

Food Sci Biotechnol

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“…The total flavonoid contents of W. arborea leaf extracts were determined as described by Fu et al 13 . Briefly, 20 μl of each extract (1 mg/ml) was mixed with 30 μl of 5 % sodium nitrite.…”

Section: Estimation Of Total Flavonoidsmentioning

confidence: 99%

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2017

IJPSR

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Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents of the leaf extracts were determined. The antioxidant activity of the extracts were investigated using DPPH, ABTS, nitric oxide scavenging assays, phosphomolybdenum assay, reducing power and metal chelating assay. Antimicrobial activity was tested against MTCC strains and MDR clinical bacteria. The antiproliferative activity was determined using MTT assay against three cancer cell lines. Results: Extracts showed high total phenolic content ranging from 85.7± 1.15 to 40.3± 0.6 gallic acid equivalents and flavonoid content ranging from 750±5.5 to 140±3.6 quercetin equivalents per gram of dry extract. Ethyl acetate extract showed highest DPPH scavenging activity with an EC 50 value of 330μg/ml. The antimicrobial effects of all the extracts were found to be genus specific -only against Klebsiella spp. The chloroform extract showed antiproliferative activity against K562 cells following 24 h exposure with an IC 50 value of 40±3μg/ml which progressively decreased to 26±2μg/ml and 5μg/ml on prolonged exposure at 48 and 72 h respectively. Conclusion: High levels of total phenolics, flavonoids, antioxidants and selective antimicrobial and antiproliferative activities of W. arborea leaf extracts have been detected in our study. This first report validates its use in traditional medicine and as a potent bioresource for neutraceuticals and therapeutics.

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“…DPPH was first dissolved with a small amount of absolute alcohol (Fu et al, 2013) and then diluted with 60% alcohol to be 0.2 mmol/L. The polyphenol extracts were dissolved with 60% alcohol at different concentrations.…”

Section: Determination Of Dpph Radical Scavengingmentioning

confidence: 99%

Antioxidantactivity of polyphenols from <i>Toona sinensis</i> roem seeds and the inhibition of aldose reductase

Wang¹,

Li²

2016

Afr. J. Trad. Compl. Alt. Med.

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Background: The seeds of Toona sinensis (Juss.) M. Roem (T. sinensis) have long been used in Traditional Chinese Medicine for the treatment of diabetes mellitus (DM) and its complications. The aim of this study was to investigate the antioxidant activity of different polyphenols fractions from Toona sinensis Roem (T. sinensis) seeds (PTSS) and the inhibition of aldose reductase (AR). Methods: Macroporous resin was used to purify PTSS, and the antioxidant activities were evaluated with total antioxidant capacity and free-radical scavenging. AR inhibitory activities were investigated by employing various established systems. Results: The polyphenol eluted by 60% alcohol (PTSS3) exhibit the highest antioxidant activity and AR inhibition, with an r value of 0.9924 ± 0.0066 in correlation analysis. The inhibition mechanism of PTSS3 on AR is uncompetitive inhibition. Conclusion: This research demonstrates that PTSS offers potential for intervening diabetes mellitus and its complications.

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Antioxidant and anti-inflammatory activities of the phenolic extracts of Sapium sebiferum (L.) Roxb. leaves

Cited by 53 publications

References 31 publications

Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

Untitled

Antioxidantactivity of polyphenols from <i>Toona sinensis</i> roem seeds and the inhibition of aldose reductase

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