Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Savcun, Gülay Yılmaz; Özkan, Erkan; Dulundu, Ender; Topaloğlu, Ümit; Şehirli, Ahmet Özer; Tok, Olgu Enis; Ercan, Feríha; Şener, Göksel

doi:10.5505/tjtes.2013.76390

Cited by 29 publications

(37 citation statements)

References 32 publications

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“…The comparative assessment between Group I and Control showed that Curcumin administration decreased oxidative stress by lowering the serum ABTS value. The values obtained validated the antioxidant effect of the tested substance (Curcumin) and are in agreement with previously published results (Gupta et al, 2009;Sharma et al, 2010;Sahin-Kavakli et al, 2011;Savcum et al, 2013;Hussein et al, 2014;Hismiogullari et al, 2014).…”

Section: Discussionsupporting

confidence: 80%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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Curcumin, a natural phenolic compound is an anti-tumor agent with anti-inflammatory and anti-oxidant properties. The aim of this research was to evaluate oxidative stress levels, the antioxidant activity and Curcumin concentrations by high performance liquid chromatography (HPLC) in an acute experimental inflammation induced by Turpentine oil (intramuscular 0.6 mg kg -1 body weight) and to compare a prophylactic versus a therapeutic regimen of Curcumin (oral suspension of 150 mg Curcumin kg -1 rat weight). Sixteen adult male Wistar rats were assigned to four groups: Control, Group I (Curcumin only), Group II (Curcumin administration, then induced inflammation after 1 hour) and Group III (induced inflammation then Curcumin administration after 2 hours). Oxidative stress was assessed by measuring serum malondialdehide and carbonylated proteins, while systemic and local total antioxidant capacity was determined by ABTS. Local tissue changes (muscle, kidney, liver) were analysed using histopathology. Results showed that acute inflammation significantly increased lipid peroxidation in Groups II and III compared to Control and Group I. A significantly reduced total antioxidant capacity (ATBS) was present in serum and kidney in Group II, also in muscle and kidney in Group III. ABTS levels were significantly increased only in the liver tissue of the animals in Groups II and III with induced inflammation as compared to Group I. This study proved the potential of Curcumin in reducing oxidative stress in both prophylactic and therapeutic regimens.

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Section: Discussionsupporting

confidence: 80%

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Coneac

Orăsan

Leucuţa

et al. 2017

Not Bot Horti Agrobo

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“…Savcun et al () have investigated the antioxidant and anti‐inflammatory effects of curcumin on oxidative and inflammatory injury in septic rat. In this study, septic rats were intraperitoneally (i.p.)…”

Section: Resultsmentioning

confidence: 99%

“…In addition, curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and histone 4 in the lysine residues. Savcun et al (2013) have investigated the antioxidant and anti-inflammatory effects of curcumin on oxidative and inflammatory injury in septic rat. In this study, septic rats were intraperitoneally (i.p.)…”

Section: In Vitro Studiesmentioning

confidence: 99%

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

Karimi

Ghodsi

Kooshki

et al. 2019

Phytotherapy Research

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Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies.

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“…The addition of LG was reported to overcome these major limitations of curcumin. LG binds to curcumin; thus, it enhances its bioactivity and improves its antioxidant ability [25, 26]. LG has various biological functions that could potentially improve our health and enhances our immune responses.…”

Section: Introductionmentioning

confidence: 99%

β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation

Tai

Chen

2016

BioMed Research International

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β-Lactoglobulin (LG) is suspected to enhance or modulate human immune responses. Moreover, LG is also hypothesized to increase human cell proliferation. However, these potential functions of LG have not been directly or thoroughly addressed. In this study, we demonstrated that LG is a potent stimulator of cell proliferation using a hybridoma cell (a splenocyte fused with a myeloma cell) model. LG's ability to promote cell proliferation was lost when the protein is denatured. To further investigate the influence of LG's conformation on cell proliferation, we chemically modified LG by either carboxymethylation (CM) or acetylation and observed significantly reduced cell proliferation when the protein structure was altered. Furthermore, we proved that LG enhances cell proliferation via receptor-mediated membrane IgM receptor. These data indicated that nondenatured LG is the major component in milk that modulates cell proliferation. Collectively, our study showed that LG plays a key role in enhancing immune responses by promoting cell proliferation through IgM receptor.

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Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Abstract: BACKGROUND:To investigate the effects of curcumin, an antioxidant and anti-inflammatory agent, on free oxygen radicals and lipid peroxidation in an experimental sepsis model, as well as to determine the role of curcumin in preventing hepatorenal tissue damage caused by sepsis.

Cited by 29 publications

References 32 publications

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Effect of Curcumin on Oxidative Stress in a Model of Turpentine Induced Acute Experimental Inflammation

Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies

β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation

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