Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans

Yang, Jung Yoon; Kim, Geum Ran; Chae, Jin Sil; Kan, Hyemin; Kim, Seong Soon; Hwang, Kyu-Seok; Lee, Byung Hoi; Yu, Shuang; Moon, Sang Won; Park, Byounghee; Bae, Myung Ae; Shin, Dae-Seop

doi:10.1007/s10068-019-00626-4

Cited by 13 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have found that Tg( mpx :EGFP) zebrafish (neutrophils are specifically labelled with green fluorescent protein) can be used to observe inflammatory responses [ 25 ], and we observed inflammation in Tg( mpx :EGFP) zebrafish. The five-day old Tg( mpx :EGFP) zebrafish larvae were randomly divided into five groups: control group, AS group, 0.1 mg/L DHWE group, 1 mg/L DHWE group, and 10 mg/L DHWE group.…”

Section: Methodsmentioning

confidence: 54%

Dendrobium catenatum Lindl. Water Extracts Attenuate Atherosclerosis

Han

Dong

Zhang

et al. 2021

Mediators of Inflammation

View full text Add to dashboard Cite

Objectives. Dendrobium catenatum Lindl. (DH) is a Chinese herbal medicine, which is often used to make tea to improve immunity in China. Rumor has it that DH has a protective effect against cardiovascular disease. However, it is not clear how DH can prevent cardiovascular disease, such as atherosclerosis (AS). Therefore, the purpose of this study is to study whether DH can prevent AS and the underlying mechanisms. Methods. Zebrafish larvae were fed with high-cholesterol diet (HCD) to establish a zebrafish AS model. Then, we used DH water extracts (DHWE) to pretreat AS zebrafish. The plaque formation was detected by HE, EVG, and oil red O staining. Neutrophil and macrophage counts were calculated to evaluate the inflammation level. Reactive oxygen species (ROS) activity, malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity in zebrafish were measured to reflect oxidative stress. The cholesterol accumulation and the levels of lipid, triglyceride (TG), and total cholesterol (TC) were measured to reflect lipid metabolism disorder. Then, parallel flow chamber was utilized to establish a low shear stress- (LSS-) induced endothelial cell (EC) dysfunction model. EA.hy926 cells were exposed to LSS (3 dyn/cm2) for 30 min and treated with DHWE. The levels of ROS, SOD, MDA, glutathione (GSH), and glutathiol (GSSG) in EA.hy926 cells were analysed to determine oxidative stress. The release of nitric oxide (NO), endothelin-1 (ET-1), and epoprostenol (PGI2) in EA.hy926 cells was measured to reflect EC dysfunction. The mRNA expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in EA.hy926 cells was detected to reflect EC dysfunction inflammation. Results. The results showed that DHWE significantly reduced cholesterol accumulation and macrophage infiltration in early AS. Finally, DHWE significantly alleviate the lipid metabolism disorder, oxidative stress, and inflammation to reduce the plaque formation of AS zebrafish larval model. Meanwhile, we also found that DHWE significantly improved LSS-induced EC dysfunction and oxidative stress in vitro. Conclusion. Our results indicate that DHWE could be used as a prevention method to prevent AS.

show abstract

Section: Methodsmentioning

confidence: 54%

Dendrobium catenatum Lindl. Water Extracts Attenuate Atherosclerosis

Han

Dong

Zhang

et al. 2021

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…These results are in concordance with Liu et al (2016), who assessed the anti‐inflammatory properties of Lactobacillus brevis K65 on RAW 264.7 cells. Similarly, Choi and Moon (2020), Jia et al (2021), Liu, Tsai, and Pan (2018), and Yang et al (2019), using RAW 264.7 cells, have distinguished that Lactobacillus paracasei had anti‐inflammatory properties. Hence, this outcome indicates that it could contribute to a profound anti‐inflammatory response's role in the development and progression of inflammatory conditions.…”

Section: Resultsmentioning

confidence: 95%

Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti‐inflammatory, and ACE inhibitory effects of fermented dromedary camel milk ( Camelus dromedaries ) and the release of antidiabetic and anti‐hypertensive peptides

Shukla¹,

Sakure

Pipaliya³

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

The goal of this investigation was to find antidiabetic peptides and inhibit angiotensin converting enzyme (ACE) in Lacticaseibacillus paracasei (M11) fermented dromedary camel milk (Camelus dromedaries). According to the findings, the rate of antidiabetic activity increased along with the incubation periods and reached its peak after 48 hr of fermentation. The inhibitions of α‐amylase, α‐glucosidase, and lipase were 80.75, 59.62, and 65.46%, respectively. The inhibitory activity of ACE was 78.33%, and the proteolytic activity was 8.90 mg/mL. M11 at 0.25 mg/mL effectively suppressed LPS‐induced pro‐inflammatory cytokines and their mediators such as NO, TNF‐α, IL‐6, and IL‐1β in RAW 264.7 cells. The rate of inoculum in the optimization phase was 1.5–2.5%, and the greatest proteolytic activity was observed after 48 hr of fermentation. The investigation of the above property in the ultrafiltered fermented milk exhibited the highest antidiabetic and ACE inhibition activities in the 3 kDa than 10 kDa fractions. The molecular weight was determined employing SDS‐PAGE, and the six‐peptide sequences were identified using 2D gel electrophoresis. Due to its high proteolytic activity, the L. paracasei strain has been reported to be useful in the production of ACE‐inhibitory and antidiabetic peptides. Amino acid sequences such from ɑ1, ɑ2, and β‐caseins have been identified within fermented camel milk by searching on online databases, including BIOPEP (for antidiabetic peptides) and AHTPDB (for hypertension peptides) to validate the antidiabetic and ACE‐inhibitory actions of several peptides. Practical applications The study aims to identify antidiabetic peptides and inhibit ACE in dromedary camel milk fermented with Lacticaseibacillus paracasei M11. Maximum antidiabetic and ACE‐inhibitory actions of the fermented camel milk were observed in 3 kDa permeate fractions. Fermented camel milk significantly reduced the excessive TNF‐α, IL‐6, and IL‐1β production in LPS‐activated RAW 264.7 cells. RP‐LC/MS was used to identify 6 bioactive peptides from dromedary fermented camel milk. This fermented camel milk could be used for the management of hypertension and diabetic related problems.

show abstract

“…Inflammation is a complex immune response of the body to injury [ 28 ]. Inflammatory response starts as an acute reaction, whereas unresolved immune activation causes chronic inflammation by affecting local tissues or systemic immunity [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Park

Kim

2021

Foods

View full text Add to dashboard Cite

Macrophages are involved in all inflammatory processes from killing pathogens to repairing damaged tissue. In the obese state, macrophages infiltrate into enlarged adipose tissue and polarize into pro-inflammatory M1 macrophages, resulting in chronic low-grade inflammation due to the secretion of inflammatory mediators. Rice bran oil (RBO) is an edible oil containing tocopherols, tocotrienols, and γ-oryzanol. Previous research in normal diet-fed mice suggested that RBO mitigates inflammatory responses by modulating mitochondrial respiration of macrophages. Therefore, we investigated if RBO had an anti-inflammatory effect in diet-induced obese mice by assessing the expression of inflammatory markers in epididymal white adipose tissue (eWAT) and polarization of bone marrow-derived macrophages (BMDMs). Rice bran oil exerted a local anti-inflammatory effect in white adipose tissue by suppressing the production of inflammatory mediators and upregulating transcription of anti-inflammatory genes. Rice bran oil also promoted anti-inflammatory M2 macrophage polarization in BMDMs thereby affecting systemic inflammation. Overall, our in vivo and ex vivo results highlight the potential of RBO as a dietary mediator that can ameliorate obesity-induced chronic low-grade inflammation by mediating the expression of inflammation-related factors and macrophage polarization.

show abstract

Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans

Cited by 13 publications

References 35 publications

Dendrobium catenatum Lindl. Water Extracts Attenuate Atherosclerosis

Dendrobium catenatum Lindl. Water Extracts Attenuate Atherosclerosis

Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti‐inflammatory, and ACE inhibitory effects of fermented dromedary camel milk ( Camelus dromedaries ) and the release of antidiabetic and anti‐hypertensive peptides

Rice Bran Oil Attenuates Chronic Inflammation by Inducing M2 Macrophage Switching in High-Fat Diet-Fed Obese Mice

Contact Info

Product

Resources

About